Crystal structure of albaflavenone monooxygenase containing a moonlighting terpene synthase active site

Journal of Biological Chemistry

Volumn 284, Issue 52, 2009, Pages 36711-36719

  Zhao, Bin ^a   Lei, Li ^a   Vassylyev, Dmitry G ^b   Lin, Xin ^c   Cane, David E ^c   Kelly, Steven L ^d   Yuan, Hang ^a   Lamb, David C ^d   Waterman, Michael R ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c BROWN UNIVERSITY   (United States)

^d SWANSEA UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BIFUNCTIONAL; CATALYTIC ACTIVITY; CYTOCHROME P450; DIVALENT CATION; EPIMERS; FARNESENE; FARNESYL DIPHOSPHATE; HELICAL DOMAINS; HEME IRON; LIGAND-FREE; MONOOXYGENASE ACTIVITIES; MONOOXYGENASES; PRIMARY SEQUENCES; REACTION MECHANISM; SIGNATURE SEQUENCES; SOIL BACTERIUM; STREPTOMYCES COELICOLOR A3(2); STRUCTURAL BASIS; SYNTHASES; X-RAY STRUCTURE;

BACTERIA; BIOCHEMISTRY; IRON COMPOUNDS; ISOMERS; OLEFINS; PORPHYRINS; SYNTHESIS (CHEMICAL);

CRYSTAL STRUCTURE;

BETA FARNESENE; CYTOCHROME P450; CYTOCHROME P450 170A1; FARNESYL DIPHOSPHATE; SESQUITERPENE; SESQUITERPENE SYNTHASE; TERPENE; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; BETA SHEET; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; ENZYME SYNTHESIS; HYDROXYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; SITE DIRECTED MUTAGENESIS; STEREOCHEMISTRY;

ALKYL AND ARYL TRANSFERASES; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; HEME; IRON; POLYISOPRENYL PHOSPHATES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SESQUITERPENES; STREPTOMYCES COELICOLOR;

BACTERIA (MICROORGANISMS); STREPTOMYCES COELICOLOR;

EID: 73649089294     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.064683     Document Type: Article

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