Glucose variability is associated with high mortality after severe burn

Journal of Trauma - Injury, Infection and Critical Care

Volumn 67, Issue 5, 2009, Pages 990-995

  Pidcoke, Heather F ^a,b   Wanek, Sandra M ^a,b   Rohleder, Laura S ^b   Holcomb, John B ^b   Wolf, Steven E ^b   Wade, Charles E ^a,b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b US ARMY INSTITUTE OF SURGICAL RESEARCH   (United States)

Author keywords

Critical care; Glucose variability; Glycemic control; Hyperglycemia; Intensive insulin; Mortality; Trauma

Indexed keywords

HUMAN INSULIN; ANTIDIABETIC AGENT; INSULIN;

ARTICLE; BODY SURFACE; BURN; CLINICAL ARTICLE; DIABETES MELLITUS; GLYCEMIC CONTROL; HOSPITALIZATION; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN TREATMENT; INTENSIVE CARE UNIT; MORTALITY; PRIORITY JOURNAL; TREATMENT OUTCOME; WOUND HEALING; ADULT; BLOOD; COMORBIDITY; GLUCOSE BLOOD LEVEL; INJURY SCALE; INTRAVENOUS DRUG ADMINISTRATION; MIDDLE AGED; SURVIVAL;

ADULT; BLOOD GLUCOSE; BURNS; COMORBIDITY; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIA; HYPOGLYCEMIC AGENTS; INFUSIONS, INTRAVENOUS; INJURY SEVERITY SCORE; INSULIN; MIDDLE AGED; SURVIVAL ANALYSIS; YOUNG ADULT;

EID: 73649088322     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e3181baef4b     Document Type: Article

References (33)

1. Laird AM, Miller PR, Kilgo PD, Meredith JW, Chang MC. Relationship of early hyperglycemia to mortality in trauma patients. J Trauma. 2004;56:1058-1062.
2. Sung J, Bochicchio GV, Joshi M, Bochicchio K, Tracy K, Scalea TM. Admission hyperglycemia is predictive of outcome in critically ill trauma patients. J Trauma. 2005;59:80-83. (Pubitemid 41271642)
3. Bochicchio GV, Salzano L, Joshi M, Bochicchio K, Scalea TM. Admission preoperative glucose is predictive of morbidity and mortality in trauma patients who require immediate operative intervention. Am Surg. 2005;71:171-174.
4. Bochicchio GV, Sung J, Joshi M, et al. Persistent hyperglycemia is predictive of outcome in critically ill trauma patients. J Trauma. 2005; 58:921-924; Erratum in: J Trauma. 2005;59:1277-1278. (Pubitemid 40776893)
5. Duane TM, Dechert T, Dalesio N, et al. Is blood sugar the next lactate? Am Surg. 2006;72:613-617; discussion 617-618.
6. Vogelzang M, Nijboer JM, van der Horst IC, Zijlstra F, ten Duis HJ, Nijsten MW. Hyperglycemia has a stronger relation with outcome in trauma patients than in other critically ill patients. J Trauma. 2006;60: 873-877; discussion 878-879.
7. Yendamuri S, Fulda GJ, Tinkoff GH. Admission hyperglycemia as a prognostic indicator in trauma. J Trauma. 2003;55:33-38.
8. Gore DC, Chinkes DL, Hart DW, Wolf SE, Herndon DN, Sanford AP. Hyperglycemia exacerbates muscle protein catabolism in burn-injured patients. Crit Care Med. 2002;30:2438-2442.
9. Gore DC, Chinkes D, Heggers J, Herndon DN, Wolf SE, Desai M. Association of hyperglycemia with increased mortality after severe burn injury. J Trauma. 2001;51:540-541.
10. Mowlavi A, Andrews K, Milner S, Herndon DN, Heggers JP. The effects of hyperglycemia on skin graft survival in the burn patient. Ann Plast Surg. 2000;45:629-632.
11. Van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med. 2001;345:1359-1367.
12. Pham TN, Warren AJ, Phan HH, Molitor F, Greenhalgh DG, Palmieri TL. Impact of tight glycemic control in severely burned children. J Trauma. 2005;59:1148-1154.
13. Heuer JG, Sharma GR, Zhang T, et al. Effects of hyperglycemia and insulin therapy on outcome in a hyperglycemic septic model of critical illness. J Trauma. 2006;60:865-872.
14. Ellger B, Debaveye Y, Vanhorebeek I, et al. Survival benefits of intensive insulin therapy in critical illness: Impact of maintaining normoglycemia versus glycemia-independent actions of insulin. Diabetes. 2006;55:1096-1105.
15. Van den Berghe G. How does blood glucose control with insulin save lives in intensive care? J Clin Invest. 2004;114:1187-1195. (Pubitemid 40385286)
16. McCowen KC, Maykel JA, Bistrian BR. Intensive insulin therapy in the critically ill patients. N Engl J Med. 2002;346:1586-1588.
17. Gore DC, Wolf SE, Herndon DN, Wolfe RR. Relative influence of glucose and insulin on peripheral amino acid metabolism in severely burned patients. JPEN J Parenter Enteral Nutr. 2002;26:271-277.
18. Jeschke MG, Klein D, Herndon DN. Insulin treatment improves the systemic inflammatory reaction to severe trauma. Ann Surg. 2004;239: 553-560.
19. Ferrando AA, Chinkes DL, Wolf SE, et al. A submaximal dose of insulin promotes net skeletal muscle protein synthesis in patients with severe burns. Ann Surg. 1999;229:11-18.
20. Kilpatrick ES, Rigby AS, Atkin SL. The effect of glucose variability on the risk of microvascular complications in type 1 diabetes. Diabetes Care. 2006;29:1486-1490.
21. Wintergerst KA, Buckingham B, Gandrud L, Wong BJ, Kache S, Wilson DM. Association of hypoglycemia, hyperglycemia, and glucose variability with morbidity and death in the pediatric intensive care unit. Pediatrics. 2006;118:173-179.
22. Mann EA, Salinas J, Pidcoke HF, et al. Error rates resulting from anemia can be corrected in commonly used point-of-care glucometers. J Trauma. 2008;64:15-21.
23. Egi M, Bellomo R, Stachowski E, French CJ, Hart G. Variability of blood glucose concentration and short-term mortality in critically ill patients. Anesthesiology. 2006;105:244-252.
24. Hart DW, Wolf SE, Mlcak R, et al. Persistence of muscle catabolism after severe burn. Surgery. 2000;128:312-319. (Pubitemid 30622500)
25. Hirsch IB, Brownlee M. Should minimal blood glucose variability become the gold standard of glycemic control? J Diabetes Complications. 2005;19: 178-181.
26. Brownlee M, Hirsch IB. Glycemic variability: A hemoglobin A1cindependent risk factor for diabetic complications. JAMA. 2006;295: 1707-1708.
27. Muggeo M, Zoppini G, Bonora E, et al. Fasting plasma glucose variability predicts 10-year survival of type 2 diabetic patients: The Verona Diabetes Study. Diabetes Care. 2000;23:45-50.
28. Hirsch IB. Glycemic variability: It's not just about A1C anymore! Diabetes Technol Ther. 2005;7:780-783.
29. Finney SJ, Zekveld C, Elia A, Evans TW. Glucose control and mortality in critically ill patients. JAMA. 2003;290:2041-2047.
30. Parsons IM IV, Buoncristiani AM, Donion S, Campbell B, Smith KL, Matsen FA III. The effect of total shoulder arthroplasty on self-assessed deficits in shoulder function in patients with capsulorrhaphy arthropathy. J Shoulder Elbow Surg. 2007;16:19S-26S.
31. Ali NA, O'Brien JM Jr, Dungan K, et al. Glucose variability and mortality in patients with sepsis. Crit Care Med. 2008;36:2316-2321.
32. Fredriksson K. FOXO, the spindle in the net for wasting diseases? J Physiol. 2008;586:5285.
33. Ni YG, Wang N, Cao DJ, et al. FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. Proc Natl Acad Sci USA. 2007;104:20517-20522.