Thrombophilia in women with pregnancy-associated complications: Fetal loss and pregnancy-related venous thromboembolism

Gynecologic and Obstetric Investigation

Volumn 69, Issue 4, 2010, Pages 233-238

  Kovac, M ^a   Mitic, G ^e   Mikovic, Z ^b   Djordjevic, V ^c   Savic, O ^a   Mandic, V ^b   Rakicevic, L J ^c   Antonijevic, N ^d   Radojkovic, D ^c  

^a Blood Transfusion Institute of Serbia   (Serbia)

^b Gynaecology and Obstetrics Clinic Narodni Front   (Serbia)

^c INSTITUTE OF MOLECULAR GENETICS AND GENETIC ENGINEERING   (Serbia)

^d CLINICAL CENTER OF SERBIA   (Serbia)

^e Clinical Center of Vojvodina Novi Sad   (Serbia)

Author keywords

Pregnancy related; Recurrent pregnancy loss; Thrombophilia; Venous thromboembolism

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN;

ADULT; ARTICLE; CONTROLLED STUDY; DOPPLER ECHOGRAPHY; FEMALE; FETUS DEATH; FETUS WASTAGE; FREQUENCY ANALYSIS; GESTATIONAL AGE; HUMAN; LABORATORY TEST; MAJOR CLINICAL STUDY; PREGNANCY COMPLICATION; PREVALENCE; PRIORITY JOURNAL; THROMBOPHILIA; VENOUS THROMBOEMBOLISM;

ADOLESCENT; ADULT; FACTOR V; FEMALE; FETAL DEATH; HUMANS; MUTATION; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY COMPLICATIONS, HEMATOLOGIC; PROTHROMBIN; THROMBOPHILIA; VENOUS THROMBOEMBOLISM;

EID: 73649083739     PISSN: 03787346     EISSN: None     Source Type: Journal    
DOI: 10.1159/000274012     Document Type: Article

References (28)

1. Brenner B: Haemostatic changes in pregnancy. Thrombosis Research 2004; 114: 409-414.
2. Bremme K: Haemostasis in normal pregnancy; in Brenner B, Marder V, Conard J, (eds): Women's Issues in Thrombosis and Haemostasis. Martin Dunitz, 2002, pp 151-165.
3. Bremme K, Ostlund E, Almqvist I, Heinonen K, Blomback M: Enhanced thrombin generation and fibrinolytic activity in the normal pregnancy and the puerperium. Obstet Gynecol 1992; 80: 132-137.
4. Clark P, Brennand J, Conkie JA, McCall F, Greer IA, Walker ID: Activated protein C sensitivity: protein C, protein S and coagulation in normal pregnancy. Thromb Haemost 1998; 79: 1166-1170.
5. Kjellberg U, Andersson NE, Rosen S, Tengborn L, Hellgren M: APC resistance and other haemostatic variables during pregnancy and puerperium. Thromb Haemost 1999; 81: 527-531.
6. Kupferminic M: Thrombophilia and pregnancy. Reprod Biol Endocrinol 2003; 1: 111.
7. Kist WJ, Janssen NG, Kalk JJ, Hague WM, Dekker GA, de Vries JI: Thrombophilias and adverse pregnancy outcome: a confounded problem! Thromb Haemost 2008; 99: 77-85.
8. Shen O, Younis JS, Samuelof A: Human gestation and pregnancy complications. In Brenner B, Marder V, Conard J (eds): Women's Issues in Thrombosis and Haemostasis. Martin Dunitz, 2002, pp 34-43.
9. Brenner B: Thrombophilia and fetal loss; in Brenner B, Marder V, Conard J (eds): Women's Issues in Thrombosis and Haemostasis. Martin Dunitz, 2002, pp 225-233.
10. Brenner B, Sarig G, Weiner Z, Younis J, Blumenfeld Z, Lanir N: Thrombophilic polymorphisms are common in women with fetal loss. Thromb Haemost 1999; 82: 6-9.
11. Kupferminic M: Thrombophilia and gestational vascular complications; in Brenner B, Marder V, Conard J (eds): Women's Issues in Thrombosis and Haemostasis. Martin Dunitz, 2002, pp 235-247.
12. Carp H, Salomon O, Seidman D, Dardik R, Rosenberg N, Inbal A: Prevalence of genetic markers for thrombophilia in recurrent pregnancy loss. Hum Reprod 2002; 17: 1633-1637.
13. Ginsberg JS, Brill-Edwards P, Burrows RF, Bona R, Prandoni P, Buller HR, Lensing A: Venous thrombosis during pregnancy: leg and trimester of presentation. Thromb Haemost 1992; 67: 519-520.
14. Greer I: Inherited thrombophilia and venous thromboembolism. Best Pract Res Clin Obstet Gynaecol 2003; 17: 413-425.
15. Marik PE, Plante LA: Venous thromboembolic disease and pregnancy. N Engl J Med 2008; 359: 2025-2033.
16. Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al: International consensus statement on an update of the classification criteria for definite antiphospholid syndrome (APS). J Thromb Haemost 2006; 4: 295-306.
17. Djordjevic V, Rakicevic LJ, Spasic M, Miljic P, Mikovic D, Kovac M, Radojkovic D: FV Leiden, FII G20210A, MTHFR C677t mutations and first venous thromboembolism duringpregnancy and puerperium. Vojnosanitet Pregl 2004; 62: 201-205.
18. Pabimger I: Thrombophilia and its impact on pregnancy. Thromb Res 2009; 123(suppl 3):516-521.
19. Hvas AM, Ingerslav J, Salvig JD: Thrombophilia risk factors are associated with intrauterine foetal death and pregnancy related venous thromboembolism. Scand J Clin Lab Invest 2008; 21: 1-7.
20. Kovac M, Mitic G, Mikovic Z, Antonijevic N, Djordjevic V, Mikovic D, Mandic V, Rakicevic L, Radojkovic D: Type and location of venous thromboembolism in carriers of factor V Leiden or prothrombin G20210A mutation versus patients with no mutation. Clin Appl Thr Haemost 2008: Epub ahead of print, DOI:1076029608320721v1.
21. Djordjevic V, Rakicevic LJ, Mikovic D, et al: Prevalence of Factor V Leiden, Factor V Cambridge, Factor II G20210A and methylenetetrahydrofolate reductase C677T mutations in healthy and thrombophilic Serbian population. Acta Haematol 2004; 112: 227-229.
22. Martinelli I, De Stefano V, Taioli E, Paciaroni K, Rossi E, Mannucci PM: Inherited thrombophilia and first venous thromboembolism during pregnancy and puerperium. J Thromb Haemost 2002; 87: 791-795.
23. Gerhardt A, Scharf RE, Beckmann MW, Struve S, Bender HG, Pillny M, Sandmann W, Zotz RB: Prothrombin and factor V mutations in women with a history of thrombosis during pregnancy and the puerperium. N Engl J Med 2000; 342: 374-380. (Pubitemid 30084535)
24. Martinelli I, Taioli E, Cetin I, Marinoni A, Gerosa S, Villa MV, Bozzo M, Mannucci PM: Mutations in coagulation factors in women with unexplained late fetal loss. N Engl J Med 2000; 343: 1015-1018.
25. Kupferminc MJ, Eldor A, Steinman N, Many A, Bar-Am A, Jaffa A, Fait G, Lessing JB: Increased frequency of genetic thrombophilia in women with complications of pregnancy. N Engl J Med 1999; 340: 9-13.
26. Pasquier E, Bohec C, Mottier D, Jaffuel S, Mercier B, Ferec C, Collet M, De Saint Martin L: Inherited thrombophilias and unexplained pregnancy loss: an incident casecontrol study. J Thromb Haemost 2009; 7: 306-311.
27. Grandone E, Margaglione M, Colaizzo D, Cappucci G, Paladini D, Martinelli P, Montanaro S, Pavone G, Di Minno G: Factor V Leiden, C 1 T MTHFR polymorphism and genetic susceptibility to preeclampsia. Thromb Haemost 1997; 77: 1052-1054.
28. Sarig G, Younis JS, Hoffman R, Lanir N, Blumenfeld Z, Brenner B: Thrombophilia is common in women with idiopathic pregnancy loss and is associated with late pregnancy wastage. Fertil Steril 2002; 77: 342-347.