Factors Associated With Neurological Recovery of Brainstem Function Following Postoperative Conformal Radiation Therapy for Infratentorial Ependymoma

International Journal of Radiation Oncology Biology Physics

Volumn 76, Issue 2, 2010, Pages 496-503

  Merchant, Thomas E ^a   Chitti, Ramana M ^a   Li, Chenghong ^a   Xiong, Xiaoping ^a   Sanford, Robert A ^b   Khan, Raja B ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b Semmes Murphy Neurological Institute   (United States)

Author keywords

Brainstem; Ependymoma; Pediatrics; Radiotherapy; Tolerance

Indexed keywords

BRAINSTEM; CEREBRO SPINAL FLUIDS; CONFORMAL RADIATION THERAPY; CRANIAL NERVES; EPENDYMOMA; FOUR-GROUP; GROSS TUMOR VOLUME; P-VALUES; PEDIATRIC PATIENTS; RISK FACTORS; STANDARD DEVIATION; TUMOR RESECTION;

DOSIMETRY; FLUORESCENT SCREENS; PEDIATRICS; RADIOTHERAPY; STATISTICS; TUMORS;

RECOVERY;

ABDUCENS NERVE; ACCESSORY NERVE; AGE DISTRIBUTION; ARTICLE; BRAIN FUNCTION; BRAIN STEM; CANCER RADIOTHERAPY; CANCER RISK; CANCER SURGERY; CEREBROSPINAL FLUID SHUNTING; CHILD; CHILDHOOD CANCER; CLINICAL TRIAL; COMPUTER ASSISTED RADIOTHERAPY; DYSMETRIA; EPENDYMOMA; FACIAL NERVE; FEMALE; FOLLOW UP; GLOSSOPHARYNGEAL NERVE; HUMAN; HYPOGLOSSAL NERVE; INFRATENTORIAL EPENDYMOMA; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MUSCLE WEAKNESS; PATIENT ASSESSMENT; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIATION DOSE; RISK ASSESSMENT; SEX DIFFERENCE; TRIGEMINAL NERVE; TUMOR VOLUME; VAGUS NERVE;

BRAIN STEM; CEREBROSPINAL FLUID SHUNTS; CHILD, PRESCHOOL; DISEASE-FREE SURVIVAL; EPENDYMOMA; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFRATENTORIAL NEOPLASMS; MALE; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; RADIATION TOLERANCE; RADIOTHERAPY, CONFORMAL; RECOVERY OF FUNCTION; REGRESSION ANALYSIS; REOPERATION; RISK FACTORS; SEX FACTORS; TUMOR BURDEN;

EID: 73549125578     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.01.079     Document Type: Article

References (17)

1. In: Ries L.A.G., Smith M.A., Gurney J.G., et al. (Eds). Cancer incidence and survival among children and adolescents: United States SEER program 1975-1995 (1999), National Cancer Institute, Bethesda, MD SEER Program, NIH pub; no. p. 99-4649
2. Merchant T.E., Haida T., Wang M.H., Finlay J.L., and Leibel S.A. Anaplastic ependymoma: Treatment of pediatric patients with or without craniospinal radiation therapy. J Neurosurg 86 (1997) 943-949
3. Pollack I.F., Gerszten P.C., Martinez A.J., et al. Intracranial ependymomas of childhood: Long-term outcome and prognostic factors. Neurosurgery 37 4 (1995) 655-666
4. van Veelen-Vincent M.L., Pierre-Kahn A., Kalifa C., et al. Ependymoma in childhood: Prognostic factors, extent of surgery, and adjuvant therapy. J Neurosurg 97 (2002) 827-835
5. Merchant T.E., Mulhern R.K., Krasin M.J., et al. Preliminary results from a phase II trial of conformal radiation therapy and evaluation of radiation-related CNS effects for pediatric patients with localized ependymoma. J Clin Oncol 22 15 (2004) 3156-3162
6. Agresti A. Categorical data analysis. 2nd ed. (2002), John Wiley & Sons, New York
7. Kalbfleisch J.D., and Prentice R.L. The statistical analysis of failure time data (1980), John Wiley, New York p. 163-188
8. SAS Institute Inc: SAS/STAT user's guide, version 9.1 (2004), SAS Institute Inc, Cary, NC
9. Cohen M.E., and Duffner P.K. Ependymomas. In: Cohen M.E., and Duffner P.K. (Eds). Brain tumors in children: Principles of diagnosis and treatment (1994), Raven Press, New York 219-239
10. Undjian S., and Marinov M. Intracranial ependymomas in children. Childs Nerv Syst 6 (1990) 131-134
11. Cochrane D.D., Gustavsson B., Poskitt K.P., Steinbok P., and Kestle J.R. The surgical and natural morbidity of aggressive resection for posterior fossa tumors in childhood. Pediatr Neurosurg 20 (1994) 19-29
12. Merchant T.E., Lee H., Zhu J., et al. The effects of hydrocephalus on intelligence quotient in children with localized infratentorial ependymoma before and after focal radiation therapy. J Neurosurg 101 Suppl 2 (2004) 159-168
13. Casey A.T., Kimmings E.J., Kleinlugtebeld A.D., et al. The long-term outlook for hydrocephalus in childhood. A ten-year cohort study of 155 patients. Pediatr Neurosurg 27 2 (1997) 63-70
14. Wu Y., Green N.L., Wrensch M.R., Zhao S., and Gupta N. Ventriculoperitoneal shunt complications in California: 1990 to 2000. Neurosurgery 61 3 (2007) 557-562
15. Vinchon M., and Dhellemmes P. Cerebrospinal fluid shunt infection: risk factors and long-term follow-up. Childs Nerv Syst 22 7 (2006) 692-697
16. Debus J., Hug E.B., Liebsch N.J., et al. Brainstem tolerance to conformal radiotherapy of skull base tumors. Int J Radiat Oncol Biol Phys 39 5 (1997) 967-975
17. Jian J.J., Cheng S.H., Tsai S.Y., et al. Improvement of local control of T3 and T4 nasopharyngeal carcinoma by hyperfractionated radiotherapy and concomitant chemotherapy. Int J Radiat Oncol Biol Phys 53 2 (2002) 344-352