Cellular mechanisms of central nervous system repair by natural autoreactive monoclonal antibodies

Archives of Neurology

Volumn 66, Issue 12, 2009, Pages 1456-1459

  Wright, Brent R ^a   Warrington, Arthur E ^a   Edberg, Dale E ^a   Rodriguez, Moses ^a,b  

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN M ANTIBODY; MONOCLONAL ANTIBODY; RECOMBINANT IMMUNOGLOBULIN M ANTIBODY 22; RECOMBINANT IMMUNOGLOBULIN M ANTIBODY 42; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; BRAIN PROTECTION; CENTRAL NERVOUS SYSTEM; CLINICAL TRIAL; DRUG BINDING; DRUG MECHANISM; FOOD AND DRUG ADMINISTRATION; HUMAN; ISOLATION PROCEDURE; MULTIPLE SCLEROSIS; NERVE CELL; NERVE FIBER GROWTH; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; REMYELINIZATION; REVIEW; SPINAL CORD INJURY; STROKE;

ANIMALS; ANTIBODIES, MONOCLONAL; AUTOANTIBODIES; AUTOANTIGENS; CENTRAL NERVOUS SYSTEM; HUMANS; MULTIPLE SCLEROSIS;

EID: 73549115379     PISSN: 00039942     EISSN: 15383687     Source Type: Journal    
DOI: 10.1001/archneurol.2009.262     Document Type: Review

References (19)

1. Coutinho A, Kazatchkine MD, Avrameas S. Natural autoantibodies. Curr Opin Immunol. 1995;7(6):812-818.
2. Howe CL, Bieber AJ, Warrington AE, Pease LR, Rodriguez M. Antiapoptotic signaling by a remyelination-promoting human antimyelin antibody. Neurobiol Dis. 2004;15(1):120-131.
3. Paz Soldán MM, Warrington AE, Bieber AJ, et al. Remyelination-promoting antibodies activate distinct Ca2+ influx pathways in astrocytes and oligodendrocytes: relationship to the mechanism of myelin repair. Mol Cell Neurosci. 2003; 22(1):14-24.
4. Pirko I, Ciric B, Gamez J, et al. A human antibody that promotes remyelination enters the CNS and decreases lesion load as detected by T2-weighted spinal cord MRI in a virus-induced murine model of MS. FASEB J. 2004;18(13):1577-1579.
5. Banks WA, Farr SA, Morley JE, Wolf KM, Geylis V, Steinitz M. Anti-amyloid beta protein antibody passage across the blood-brain barrier in the SAMP8 mouse model of Alzheimer's disease: an age-related selective uptake with reversal of learning impairment. Exp Neurol. 2007;206(2):248-256.
6. Miller DJ, Rodriguez M. A monoclonal autoantibody that promotes central nervous system remyelination in a model of multiple sclerosis is a natural autoantibody encoded by germline immunoglobulin genes. J Immunol. 1995;154 (5):2460-2469.
7. Asakura K, Miller DJ, Pease LR, Rodriguez M. Targeting of IgMkappa antibodies to oligodendrocytes promotes CNS remyelination. J Neurosci. 1998;18(19): 7700-7708.
8. Miller DJ, Njenga MK, Parisi JE, Rodriguez M. Multi-organ reactivity of a monoclonal natural autoantibody that promotes remyelination in a mouse model of multiple sclerosis. J Histochem Cytochem. 1996;44(9):1005-1011.
9. Mitsunaga Y, Ciric B, Van Keulen V, et al. Direct evidence that a human antibody derived from patient serum can promote myelin repair in a mouse model of chronic-progressive demyelinating disease. FASEB J. 2002;16(10):1325-1327.
10. Warrington AE, Bieber AJ, Van Keulen V, Ciric B, Pease LR, Rodriguez M. Neuron-binding human monoclonal antibodies support central nervous system neurite extension. J Neuropathol Exp Neurol. 2004;63(5):461-473.
11. Howe CL, Mayoral S, Rodriguez M. Activated microglia stimulate transcriptional changes in primary oligodendrocytes via IL-1beta. Neurobiol Dis. 2006;23(3): 731-739.
12. Warrington AE, Asakura K, Bieber AJ, et al. Human monoclonal antibodies reactive to oligodendrocytes promote remyelination in a model of multiple sclerosis. Proc Natl Acad Sci U S A. 2000;97(12):6820-6825.
13. Warrington AE, Bieber AJ, Ciric B, Pease LR, Van Keulen V, Rodriguez M. A recombinant human IgM promotes myelin repair after a single, very low dose. J Neurosci Res. 2007;85(5):967-976.
14. Radhakrishnan S, Nguyen LT, Ciric B, et al. Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity. Cancer Res. 2004;64(14):4965-4972.
15. Fredman P, Magnani JL, Nirenberg M, Ginsburg V. Monoclonal antibody A2B5 reacts with many gangliosides in neuronal tissue. Arch Biochem Biophys. 1984; 233(2):661-666.
16. Sommer I, Schachner M. Monoclonal antibodies (O1 to O4) to oligodendrocyte cell surfaces: an immunocytological study in the central nervous system. Dev Biol. 1981;83(2):311-327.
17. Chou DK, Ilyas AA, Evans JE, Costello C, Quarles RH, Jungalwala FB. Structure of sulfated glucuronyl glycolipids in the nervous system reacting with HNK-1 antibody and some IgM paraproteins in neuropathy. J Biol Chem. 1986;261(25): 11717-11725.
18. Hirahara Y, Bansal R, Honke K, Ikenaka K, Wada Y. Sulfatide is a negative regulator of oligodendrocyte differentiation: development in sulfatide-null mice. Glia. 2004;45(3):269-277.
19. Milner R, Frost E, Nishimura S, et al. Expression of alpha vbeta3 and alpha vbeta8 integrins during oligodendrocyte precursor differentiation in the presence and absence of axons. Glia. 1997;21(4):350-360.