Reduced pain with use of proprietary hyaluronic acid with lidocaine for correction of nasolabial folds: A patient-blinded, prospective, randomized controlled trial

Dermatologic Surgery

Volumn 36, Issue 1, 2010, Pages 94-101

  Monheit, Gary D ^a,b   Campbell, Ross M ^c   Neugent, Heidi ^b   Nelson, Candi P ^b,d   Prather, Chad L ^c   Bachtell, Nathan ^d   Eng, Denise ^d   Holmdahl, Lena ^d  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b TOTAL   (France)

^c Georgia Skin Cancer and Aesthetic Dermatology   (Greece)

^d GENZYME CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPTIQUE; HYALURONIC ACID; LIDOCAINE; PREVELLE; UNCLASSIFIED DRUG;

ADULT; AGED; ANALGESIA; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG SAFETY; ESTHETIC SURGERY; FACE; FEMALE; HUMAN; INJECTION SITE CONTUSION; INJECTION SITE DESQUAMATION; INJECTION SITE IRRITATION; INJECTION SITE PAIN; INJECTION SITE REACTION; INJECTION SITE SWELLING; MALE; NASOLABIAL FOLD; ONYCHOMYCOSIS; PAIN ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RHINOPHARYNGITIS; SINGLE BLIND PROCEDURE; SKIN DISCOLORATION; SKIN IRRITATION; SKINFOLD; TREATMENT OUTCOME; VIRAL GASTROENTERITIS; VISUAL ANALOG SCALE; WRINKLE;

ADULT; AGED; ANESTHETICS, LOCAL; COSMETIC TECHNIQUES; DERMATOLOGIC AGENTS; FEMALE; HUMANS; HYALURONIC ACID; LIDOCAINE; MALE; MIDDLE AGED; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PROSPECTIVE STUDIES; SINGLE-BLIND METHOD; SKIN AGING;

EID: 73549094667     PISSN: 10760512     EISSN: 15244725     Source Type: Journal    
DOI: 10.1111/j.1524-4725.2009.01389.x     Document Type: Article

References (19)

1. American Society for Dermatologic Surgery 2005 Procedure Survey: Dermasurgery Trends and Statistics. Rolling Meadows, IL : Dermatologic Surgery 2006.
2. Cosmetic Surgery National Data Bank Statistics. New York: American Society for Aesthetic Plastic Surgery. 2007 [on-line]. Available at (Accessed February 27, 2008).
3. Cell junctions, cell adhesion, and the extracellular matrix. In : Alberts B, Johnson A, Lewis J, et al., editors. The Molecular Biology of the Cell. 4th ed. New York : Garland Science 2002. p. 1065.
4. Almond A. Hyaluronan. Cell Mol Life Sci 2007 64 : 1591 1596.
5. Laurent UBG, Reed RK. Turnover of hyaluronan in the tissues. Adv Drug Deliv Rev 1991 7 : 237 256.
6. Gold MH. Use of hyaluronic acid fillers for the treatment of the aging face. Clin Interv Aging 2007 2 : 369 376.
7. Monheit GD. Hylaform: a new hyaluronic acid filler. Facial Plast Surg 2004 20 : 153 155.
8. Monheit GD. Hyaluronic acid fillers: Hylaform and Captique. Facial Plast Surg Clin North Am 2007 15 : 77 84, vii.
9. Yu L-P, Yang L, Voschin E, Kablik J. Comparison of HA fragment concentration and molecular weight in various HA-based dermal filler products. 66th Annual Meeting, American Academy of Dermatology. San Antonio, TX. February 1-5, 2008.
10. Matarasso SL, Carruthers JD, Jewell ML. Consensus recommendations for soft-tissue augmentation with nonanimal stabilized hyaluronic acid (Restylane). Plast Reconstr Surg 2006 117 (3 Suppl) : 3S 34S discussion 5S-43S.
11. Baumann LS, Shamban AT, Lupo MP, et al. Comparison of smooth-gel hyaluronic acid dermal fillers with cross-linked bovine collagen: a multicenter, double-masked, randomized, within-subject study. Dermatol Surg 2007 33 (Suppl 2) : S128 35.
12. Grekin RC, Auletta MJ. Local anesthesia in dermatologic surgery. J Am Acad Dermatol 1988 19 : 599 614.
13. Huang W, Vidimos A. Topical anesthetics in dermatology. J Am Acad Dermatol 2000 43 (2 Pt 1) : 286 298.
14. Prevelle SILK [Prescribing Information]. Mentor Corporation. Santa Barbara, CA. 2008.
15. Hylaform (hylan B gel) - P030032. United States Food and Drug Administration, Center for Devices and Radiological Heath. 2004. Available at (Accessed March 5, 2008).
16. Grimes PE, Taylor SC, Grekin SK, et al Safety and effectiveness of low concentration hyaluronic acid fillers in skin of color. Poster. Plastic Surgery 2007. Baltimore, MD. 2007.
17. Lemperle G, Holmes RE, Cohen SR, Lemperle SM. A classification of facial wrinkles. Plast Reconstr Surg 2001 108 : 1735 1750 discussion 51-2. (Pubitemid 33032646)
18. Fitzpatrick TB. The validity and practicality of sun-reactive skin types I through VI. Arch Dermatol 1988 124 : 869 871.
19. Achar S, Kundu S. Principles of office anesthesia: part I. Infiltrative anesthesia. Am Fam Phys 2002 66 : 91 4.