메뉴 건너뛰기




Volumn 175, Issue 6, 2009, Pages 2489-2500

Robust Th1 and Th17 immunity supports pulmonary clearance but cannot prevent systemic dissemination of highly virulent Cryptococcus neoformans H99

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4;

EID: 73549089697     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2009.090530     Document Type: Article
Times cited : (142)

References (47)
  • 4
    • 4544251213 scopus 로고    scopus 로고
    • Cryptococcus neoformans infections at Vancouver Hospital and Health Sciences Centre (1997-2002): Epidemiology, microbiology and histopathology
    • Hoang LM, Maguire JA, Doyle P, Fyfe M, Roscoe DL: Cryptococcus neoformans infections at Vancouver Hospital and Health Sciences Centre (1997-2002): epidemiology, microbiology and histopathology. J Med Microbiol 2004, 53:935-940
    • (2004) J Med Microbiol , vol.53 , pp. 935-940
    • Hoang, L.M.1    Maguire, J.A.2    Doyle, P.3    Fyfe, M.4    Roscoe, D.L.5
  • 5
    • 2342518789 scopus 로고    scopus 로고
    • Cryptococcal meningitis in two apparently immunocompetent Maltese patients
    • Zahra LV, Azzopardi CM, Scott G: Cryptococcal meningitis in two apparently immunocompetent Maltese patients. Mycoses 2004, 47:168-173
    • (2004) Mycoses , vol.47 , pp. 168-173
    • Zahra, L.V.1    Azzopardi, C.M.2    Scott, G.3
  • 6
    • 3843079480 scopus 로고    scopus 로고
    • Disseminated pulmonary infection due to Cryptococcus neoformans in a non immunocompromised patient
    • Hofman V, Venissac N, Mouroux C, Butori C, Mouroux J, Hofman P: Disseminated pulmonary infection due to Cryptococcus neoformans in a non immunocompromised patient. Ann Pathol 2004, 24:187-191
    • (2004) Ann Pathol , vol.24 , pp. 187-191
    • Hofman, V.1    Venissac, N.2    Mouroux, C.3    Butori, C.4    Mouroux, J.5    Hofman, P.6
  • 7
    • 0029128980 scopus 로고
    • Down-regulation of the afferent phase of T cell-mediated pulmonary inflammation and immunity by a high melanin-producing strain of Cryptococcus neoformans
    • Huffnagle GB, Chen GH, Curtis JL, McDonald RA, Strieter RM, Toews GB: Down-regulation of the afferent phase of T cell-mediated pulmonary inflammation and immunity by a high melanin-producing strain of Cryptococcus neoformans. J Immunol 1995, 155:3507-3516
    • (1995) J Immunol , vol.155 , pp. 3507-3516
    • Huffnagle, G.B.1    Chen, G.H.2    Curtis, J.L.3    McDonald, R.A.4    Strieter, R.M.5    Toews, G.B.6
  • 11
    • 0034818462 scopus 로고    scopus 로고
    • Regulatory effects of macrophage inflammatory protein 1alpha/CCL3 on the development of immunity to Cryptococcus neoformans depend on expression of early inflammatory cytokines
    • Olszewski MA, Huffnagle GB, Traynor TR, McDonald RA, Cook DN, Toews GB: Regulatory effects of macrophage inflammatory protein 1alpha/CCL3 on the development of immunity to Cryptococcus neoformans depend on expression of early inflammatory cytokines. Infect Immun 2001, 69:6256-6263
    • (2001) Infect Immun , vol.69 , pp. 6256-6263
    • Olszewski, M.A.1    Huffnagle, G.B.2    Traynor, T.R.3    McDonald, R.A.4    Cook, D.N.5    Toews, G.B.6
  • 12
    • 0032967578 scopus 로고    scopus 로고
    • Differential regulation of immune responses by highly and weakly virulent Cryptococcus neoformans isolates
    • Blackstock R, Buchanan KL, Adesina AM, Murphy JW: Differential regulation of immune responses by highly and weakly virulent Cryptococcus neoformans isolates. Infect Immun 1999, 67:3601-3609
    • (1999) Infect Immun , vol.67 , pp. 3601-3609
    • Blackstock, R.1    Buchanan, K.L.2    Adesina, A.M.3    Murphy, J.W.4
  • 13
    • 1942533402 scopus 로고    scopus 로고
    • Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion
    • Olszewski MA, Noverr MC, Chen GH, Toews GB, Cox GM, Perfect JR, Huffnagle GB: Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion. Am J Pathol 2004, 164:1761-1771
    • (2004) Am J Pathol , vol.164 , pp. 1761-1771
    • Olszewski, M.A.1    Noverr, M.C.2    Chen, G.H.3    Toews, G.B.4    Cox, G.M.5    Perfect, J.R.6    Huffnagle, G.B.7
  • 15
    • 60549098253 scopus 로고    scopus 로고
    • Virulence in Cryptococcus species
    • Ma H, May RC: Virulence in Cryptococcus species. Adv Appl Microbiol 2009, 67:131-190
    • (2009) Adv Appl Microbiol , vol.67 , pp. 131-190
    • Ma, H.1    May, R.C.2
  • 16
    • 0034651769 scopus 로고    scopus 로고
    • CCR2 expression determines T1 versus T2 polarization during pulmonary Cryptococcus neoformans infection
    • Traynor TR, Kuziel WA, Toews GB, Huffnagle GB: CCR2 expression determines T1 versus T2 polarization during pulmonary Cryptococcus neoformans infection. J Immunol 2000, 164:2021-2027
    • (2000) J Immunol , vol.164 , pp. 2021-2027
    • Traynor, T.R.1    Kuziel, W.A.2    Toews, G.B.3    Huffnagle, G.B.4
  • 17
    • 18644377865 scopus 로고    scopus 로고
    • Role of IFN-gamma in regulating T2 immunity and the development of alternatively activated macrophages during allergic bronchopulmonary mycosis
    • Arora S, Hernandez Y, Erb-Downward JR, McDonald RA, Toews GB, Huffnagle GB: Role of IFN-gamma in regulating T2 immunity and the development of alternatively activated macrophages during allergic bronchopulmonary mycosis. J Immunol 2005, 174:6346-6356
    • (2005) J Immunol , vol.174 , pp. 6346-6356
    • Arora, S.1    Hernandez, Y.2    Erb-Downward, J.R.3    McDonald, R.A.4    Toews, G.B.5    Huffnagle, G.B.6
  • 20
    • 0028053270 scopus 로고
    • The role of CD4+ and CD8+ T cells in the protective inflammatory response to a pulmonary cryptococcal infection
    • Huffnagle GB, Lipscomb MF, Lovchik JA, Hoag KA, Street NE: The role of CD4+ and CD8+ T cells in the protective inflammatory response to a pulmonary cryptococcal infection. J Leukoc Biol 1994, 55:35-42
    • (1994) J Leukoc Biol , vol.55 , pp. 35-42
    • Huffnagle, G.B.1    Lipscomb, M.F.2    Lovchik, J.A.3    Hoag, K.A.4    Street, N.E.5
  • 21
    • 11144284083 scopus 로고    scopus 로고
    • Transient neutralization of tumor necrosis factor alpha can produce a chronic fungal infection in an immunocompetent host: Potential role of immature dendritic cells
    • Herring AC, Falkowski NR, Chen GH, McDonald RA, Toews GB, Huffnagle GB: Transient neutralization of tumor necrosis factor alpha can produce a chronic fungal infection in an immunocompetent host: potential role of immature dendritic cells. Infect Immun 2005, 73:39-49
    • (2005) Infect Immun , vol.73 , pp. 39-49
    • Herring, A.C.1    Falkowski, N.R.2    Chen, G.H.3    McDonald, R.A.4    Toews, G.B.5    Huffnagle, G.B.6
  • 22
    • 15544372839 scopus 로고    scopus 로고
    • The gamma interferon receptor is required for the protective pulmonary inflammatory response to Cryptococcus neoformans
    • Chen GH, McDonald RA, Wells JC, Huffnagle GB, Lukacs NW, Toews GB: The gamma interferon receptor is required for the protective pulmonary inflammatory response to Cryptococcus neoformans. Infect Immun 2005, 73:1788-1796
    • (2005) Infect Immun , vol.73 , pp. 1788-1796
    • Chen, G.H.1    McDonald, R.A.2    Wells, J.C.3    Huffnagle, G.B.4    Lukacs, N.W.5    Toews, G.B.6
  • 23
    • 11844297838 scopus 로고    scopus 로고
    • Distinct roles for IL-4 and IL-10 in regulating T2 immunity during allergic bronchopulmonary mycosis
    • Hernandez Y, Arora S, Erb-Downward JR, McDonald RA, Toews GB, Huffnagle GB: Distinct roles for IL-4 and IL-10 in regulating T2 immunity during allergic bronchopulmonary mycosis. J Immunol 2005, 174:1027-1036
    • (2005) J Immunol , vol.174 , pp. 1027-1036
    • Hernandez, Y.1    Arora, S.2    Erb-Downward, J.R.3    McDonald, R.A.4    Toews, G.B.5    Huffnagle, G.B.6
  • 24
    • 9644262463 scopus 로고    scopus 로고
    • Signaling pathways in Th2 development
    • Mowen KA, Glimcher LH: Signaling pathways in Th2 development. Immunol Rev 2004, 202:203-222
    • (2004) Immunol Rev , vol.202 , pp. 203-222
    • Mowen, K.A.1    Glimcher, L.H.2
  • 26
    • 46249085507 scopus 로고    scopus 로고
    • Inheritance of immune polarization patterns is linked to resistance versus susceptibility to Cryptococcus neoformans in a mouse model
    • Chen GH, McNamara DA, Hernandez Y, Huffnagle GB, Toews GB, Olszewski MA: Inheritance of immune polarization patterns is linked to resistance versus susceptibility to Cryptococcus neoformans in a mouse model. Infect Immun 2008, 76:2379-2391
    • (2008) Infect Immun , vol.76 , pp. 2379-2391
    • Chen, G.H.1    McNamara, D.A.2    Hernandez, Y.3    Huffnagle, G.B.4    Toews, G.B.5    Olszewski, M.A.6
  • 27
    • 0033543946 scopus 로고    scopus 로고
    • Interleukin-4 weakens host resistance to pulmonary and disseminated cryptococcal infection caused by combined treatment with interferon-gamma- inducing cytokines
    • Kawakami K, Hossain Qureshi M, Zhang T, Koguchi Y, Xie Q, Kurimoto M, Saito A: Interleukin-4 weakens host resistance to pulmonary and disseminated cryptococcal infection caused by combined treatment with interferon-gamma- inducing cytokines. Cell Immunol 1999, 197:55-61
    • (1999) Cell Immunol , vol.197 , pp. 55-61
    • Kawakami, K.1    Hossain Qureshi, M.2    Zhang, T.3    Koguchi, Y.4    Xie, Q.5    Kurimoto, M.6    Saito, A.7
  • 28
    • 56649089785 scopus 로고    scopus 로고
    • A gene-dosage effect for interleukin-4 receptor alpha-chain expression has an impact on Th2-mediated allergic inflammation during bronchopulmonary mycosis
    • Muller U, Stenzel W, Kohler G, Polte T, Blessing M, Mann A, Piehler D, Brombacher F, Alber G: A gene-dosage effect for interleukin-4 receptor alpha-chain expression has an impact on Th2-mediated allergic inflammation during bronchopulmonary mycosis. J Infect Dis 2008, 198:1714-1721
    • (2008) J Infect Dis , vol.198 , pp. 1714-1721
    • Muller, U.1    Stenzel, W.2    Kohler, G.3    Polte, T.4    Blessing, M.5    Mann, A.6    Piehler, D.7    Brombacher, F.8    Alber, G.9
  • 29
    • 0034541230 scopus 로고    scopus 로고
    • The role of macrophage inflammatory protein-1alpha/CCL3 in regulation of T cell-mediated immunity to Cryptococcus neoformans infection
    • Olszewski MA, Huffnagle GB, McDonald RA, Lindell DM, Moore BB, Cook DN, Toews GB: The role of macrophage inflammatory protein-1alpha/CCL3 in regulation of T cell-mediated immunity to Cryptococcus neoformans infection. J Immunol 2000, 165:6429-6436
    • (2000) J Immunol , vol.165 , pp. 6429-6436
    • Olszewski, M.A.1    Huffnagle, G.B.2    McDonald, R.A.3    Lindell, D.M.4    Moore, B.B.5    Cook, D.N.6    Toews, G.B.7
  • 30
    • 59649122244 scopus 로고    scopus 로고
    • IL-4/IL-13-dependent alternative activation of macrophages but not microglial cells is associated with uncontrolled cerebral cryptococcosis
    • Stenzel W, Muller U, Kohler G, Heppner FL, Blessing M, McKenzie AN, Brombacher F, Alber G: IL-4/IL-13-dependent alternative activation of macrophages but not microglial cells is associated with uncontrolled cerebral cryptococcosis. Am J Pathol 2009, 174:486-496
    • (2009) Am J Pathol , vol.174 , pp. 486-496
    • Stenzel, W.1    Muller, U.2    Kohler, G.3    Heppner, F.L.4    Blessing, M.5    McKenzie, A.N.6    Brombacher, F.7    Alber, G.8
  • 32
    • 0037373354 scopus 로고    scopus 로고
    • Role of PLB1 in pulmonary inflammation and cryptococcal eicosanoid production
    • Noverr MC, Cox GM, Perfect JR, Huffnagle GB: Role of PLB1 in pulmonary inflammation and cryptococcal eicosanoid production. Infect Immun 2003, 71:1538-1547
    • (2003) Infect Immun , vol.71 , pp. 1538-1547
    • Noverr, M.C.1    Cox, G.M.2    Perfect, J.R.3    Huffnagle, G.B.4
  • 33
    • 33847736330 scopus 로고    scopus 로고
    • Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain
    • Wormley FL Jr, Perfect JR, Steele C, Cox GM: Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain. Infect Immun 2007, 75:1453-1462
    • (2007) Infect Immun , vol.75 , pp. 1453-1462
    • Wormley Jr, F.L.1    Perfect, J.R.2    Steele, C.3    Cox, G.M.4
  • 34
    • 0033577811 scopus 로고    scopus 로고
    • Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses
    • McKenzie GJ, Fallon PG, Emson CL, Grencis RK, McKenzie AN: Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses. J Exp Med 1999, 189:1565-1572
    • (1999) J Exp Med , vol.189 , pp. 1565-1572
    • McKenzie, G.J.1    Fallon, P.G.2    Emson, C.L.3    Grencis, R.K.4    McKenzie, A.N.5
  • 35
    • 0032032243 scopus 로고    scopus 로고
    • IL-5 is required for eosinophil recruitment, crystal deposition, and mononuclear cell recruitment during a pulmonary Cryptococcus neoformans infection in genetically susceptible mice (C57BL/6)
    • Huffnagle GB, Boyd MB, Street NE, Lipscomb MF: IL-5 is required for eosinophil recruitment, crystal deposition, and mononuclear cell recruitment during a pulmonary Cryptococcus neoformans infection in genetically susceptible mice (C57BL/6). J Immunol 1998, 160:2393-2400
    • (1998) J Immunol , vol.160 , pp. 2393-2400
    • Huffnagle, G.B.1    Boyd, M.B.2    Street, N.E.3    Lipscomb, M.F.4
  • 36
    • 47949122479 scopus 로고    scopus 로고
    • CCR2 mediates conventional dendritic cell recruitment and the formation of bronchovascular mononuclear cell infiltrates in the lungs of mice infected with Cryptococcus neoformans
    • Osterholzer JJ, Curtis JL, Polak T, Ames T, Chen GH, McDonald R, Huffnagle GB, Toews GB: CCR2 mediates conventional dendritic cell recruitment and the formation of bronchovascular mononuclear cell infiltrates in the lungs of mice infected with Cryptococcus neoformans. J Immunol 2008, 181:610-620
    • (2008) J Immunol , vol.181 , pp. 610-620
    • Osterholzer, J.J.1    Curtis, J.L.2    Polak, T.3    Ames, T.4    Chen, G.H.5    McDonald, R.6    Huffnagle, G.B.7    Toews, G.B.8
  • 37
    • 0346373587 scopus 로고    scopus 로고
    • Role of interleukin-4 in resistance to Cryptococcus neoformans infection
    • Blackstock R, Murphy JW: Role of interleukin-4 in resistance to Cryptococcus neoformans infection. Am J Respir Cell Mol Biol 2004, 30:109-117
    • (2004) Am J Respir Cell Mol Biol , vol.30 , pp. 109-117
    • Blackstock, R.1    Murphy, J.W.2
  • 40
    • 20444378194 scopus 로고    scopus 로고
    • Generation of antifungal effector CD8+ T cells in the absence of CD4+ T cells during Cryptococcus neoformans infection
    • Lindell DM, Moore TA, McDonald RA, Toews GB, Huffnagle GB: Generation of antifungal effector CD8+ T cells in the absence of CD4+ T cells during Cryptococcus neoformans infection. J Immunol 2005, 174:7920-7928
    • (2005) J Immunol , vol.174 , pp. 7920-7928
    • Lindell, D.M.1    Moore, T.A.2    McDonald, R.A.3    Toews, G.B.4    Huffnagle, G.B.5
  • 41
    • 0037442137 scopus 로고    scopus 로고
    • IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger
    • Ferretti S, Bonneau O, Dubois GR, Jones CE, Trifilieff A: IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: iL-15 as a possible trigger. J Immunol 2003, 170:2106-2112
    • (2003) J Immunol , vol.170 , pp. 2106-2112
    • Ferretti, S.1    Bonneau, O.2    Dubois, G.R.3    Jones, C.E.4    Trifilieff, A.5
  • 42
    • 0022653478 scopus 로고
    • Macrophage-mediated fungistasis in vitro: Requirements for intracellular and extracellular cytotoxicity
    • Granger DL, Perfect JR, Durack DT: Macrophage-mediated fungistasis in vitro: requirements for intracellular and extracellular cytotoxicity. J Immunol 1986, 136:672-680
    • (1986) J Immunol , vol.136 , pp. 672-680
    • Granger, D.L.1    Perfect, J.R.2    Durack, D.T.3
  • 43
    • 0029337253 scopus 로고
    • A role for gamma interferoninduced nitric oxide in pulmonary clearance of Cryptococcus neoformans
    • Lovchik JA, Lyons CR, Lipscomb MF: A role for gamma interferoninduced nitric oxide in pulmonary clearance of Cryptococcus neoformans. Am J Respir Cell Mol Biol 1995, 13:116-124
    • (1995) Am J Respir Cell Mol Biol , vol.13 , pp. 116-124
    • Lovchik, J.A.1    Lyons, C.R.2    Lipscomb, M.F.3
  • 44
    • 0027988178 scopus 로고
    • Encapsulation of Cryptococcus neoformans regulates fungicidal activity and the antigen presentation process in human alveolar macrophages
    • Vecchiarelli A, Pietrella D, Dottorini M, Monari C, Retini C, Todisco T, Bistoni F: Encapsulation of Cryptococcus neoformans regulates fungicidal activity and the antigen presentation process in human alveolar macrophages. Clin Exp Immunol 1994, 98:217-223
    • (1994) Clin Exp Immunol , vol.98 , pp. 217-223
    • Vecchiarelli, A.1    Pietrella, D.2    Dottorini, M.3    Monari, C.4    Retini, C.5    Todisco, T.6    Bistoni, F.7
  • 45
    • 0031184059 scopus 로고    scopus 로고
    • Macrophage inflammatory protein-1alpha (MIP-1alpha) is required for the efferent phase of pulmonary cellmediated immunity to a Cryptococcus neoformans infection
    • Huffnagle GB, Strieter RM, McNeil LK, McDonald RA, Burdick MD, Kunkel SL, Toews GB: Macrophage inflammatory protein-1alpha (MIP-1alpha) is required for the efferent phase of pulmonary cellmediated immunity to a Cryptococcus neoformans infection. J Immunol 1997, 159:318-327
    • (1997) J Immunol , vol.159 , pp. 318-327
    • Huffnagle, G.B.1    Strieter, R.M.2    McNeil, L.K.3    McDonald, R.A.4    Burdick, M.D.5    Kunkel, S.L.6    Toews, G.B.7
  • 47
    • 58449131342 scopus 로고    scopus 로고
    • Evidence of a role for monocytes in dissemination and brain invasion by Cryptococcus neoformans
    • Charlier C, Nielsen K, Daou S, Brigitte M, Chretien F, Dromer F: Evidence of a role for monocytes in dissemination and brain invasion by Cryptococcus neoformans. Infect Immun 2009, 77:120-127
    • (2009) Infect Immun , vol.77 , pp. 120-127
    • Charlier, C.1    Nielsen, K.2    Daou, S.3    Brigitte, M.4    Chretien, F.5    Dromer, F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.