Safety evaluation of Calcium administered intranasally to mice

International Journal of Toxicology

Volumn 28, Issue 6, 2009, Pages 510-518

  Patel, Girishchandra B ^a   Zhou, Hongyan ^a   Ponce, Amalia ^a   Chen, Wangxue ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Calcium; Intranasal; Safety; Toxicity; Vaccine

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; BILIRUBIN; CALCIUM; CREATININE; GLOBULIN; GLUCOSE; PROTEIN; UREA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; BILIRUBIN BLOOD LEVEL; BODY WEIGHT; BRONCHOPNEUMONIA; C57BL 6 MOUSE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; EVALUATION; EXPERIMENTAL MODEL; FEMALE; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; MOUSE; MOUSE STRAIN; NONHUMAN; PNEUMONIA; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; TOXICITY TESTING; UREA NITROGEN BLOOD LEVEL;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INTRANASAL; ANIMALS; BEHAVIOR, ANIMAL; BLOOD CHEMICAL ANALYSIS; BODY WEIGHT; CALCIUM CHLORIDE; CHEMISTRY, PHARMACEUTICAL; FEMALE; LIVER FUNCTION TESTS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; SPECIES SPECIFICITY;

ANIMALIA; MUS;

EID: 73549088523     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1177/1091581809347388     Document Type: Article

References (22)

1. Relyveld E, Bengounia A, Huet M, Kreeftenberg JG. Antibody response of pregnant women to two different absorbed tetanus toxoids. Vaccine. 1991;9:369-372.
2. Gupta RK, Rost BE, Relyveld E, Siber GR. Adjuvant properties of aluminum and calcium compounds. In: Powell MF, Newman MJ, eds. Vaccine Design: The Subunit Approach. New York, NY: Plenum; 1995:229-248.
3. Sesardic D, Rijpkema S, Patel BP. New adjuvants: EU regulatory developments. Expert Rev Vaccines. 2007;6:849-861.
4. Gupta RK, Siber GR. Comparison of adjuvant activities of aluminum phosphate, calcium phosphate and stearyl tyrosine for tetanus toxoid. Biologicals. 1994;22:53-63.
5. Goto N, Kato H, Maeyama J, et al. Local tissue irritating effects and adjuvant activities of calcium phosphate and aluminum hydroxide with different physical properties. Vaccine. 1997; 15:1364-1371.
6. Relyveld EH. Preparation and use of calcium phosphate adsorbed vaccines. Dev Biol Stand. 1986;65:131-136.
7. He Q, Mitchell AR, Johnson SL, Wagner-Bartak C, Morcol T, Bell SJ. Calcium phosphate nanoparticle adjuvant. Clin Diagn Lab Immunol. 2000;7:899-903.
8. He Q, Mitchell A, Morcol T, Bell SJ. Calcium phosphate nanoparticles induce mucosal immunity and protection against herpes simplex virus type 2. Clin Diagn Lab Immunol. 2002;9: 1021-1024.
9. Gould-Fogerite S, Mannino RJ. Mucosal and systemic immunization using cochleate and liposome vaccines. J Liposome Res. 1996;6:357-379.
10. Gould-Fogerite S, Kheiri MT, Zhang F, et al. Targeting immune response induction with cochleate and liposome-based vaccines. Adv Drug Deliv Rev. 1998;32:273-287.
11. Perez O, Bracho G, Lastre M, et al. Proteoliposome-derived Cochleate as an immunomodulator for nasal vaccine. Vaccine. 2006;24:S2-52-53.
12. Zayas C, Bracho G, Lastre M, et al. Scale up of proteoliposome derived Cochleate production. Vaccine. 2006;24:S2-94-95.
13. Patel GB, Zhou H, Ponce A, Chen W. Mucosal and systemic immune responses by intranasal immunization using archaeal lipid-adjuvanted vaccines. Vaccine. 2007;25:8622-8636.
14. Patel GB, Ponce A, Zhou H, Chen W. Structural characterization of archaeal lipid mucosal vaccine adjuvant and delivery (AMVAD) formulations prepared by different protocols and their efficacy upon intranasal immunization of mice. J Liposome Res. 2008;18:127-143.
15. Vassilev TL. Aluminum phosphate but not calcium phosphate stimulates the specific IgE response in guinea pigs to tetanus toxoid. Allergy. 1978;33:155-159.
16. Relyveld EH, Ickovic MR, Henocq E, Garcelon M. Calcium phosphate adjuvanted allergens. Ann Allergy. 1985;54:521-529.
17. Byrd W, Cassels FJ. Intranasal immunization of BALB/c mice with enterotoxigenic Escherichia coli colonization factor CS6 encapsulated in biodegradable poly (DL-lactide-co-glycolide) microspheres. Vaccine. 2006;24:1359-1366.
18. Aguilar JC, Rodriguez EG. Vaccine adjuvants revisited. Vaccine. 2007;25:3752-3762.
19. Patel GB, Ponce A, Zhou H, Chen W. Safety of intranasally administered archaeal lipid mucosal vaccine adjuvant and delivery (AMVAD) vaccine in mice. Int J Toxicol. 2008;27:329-339.
20. Wiercinski FJ. Calcium, an overview-1989. Biol Bull. 1989;176:195-217.
21. Rasmussen H, Barrett P, Smallwood J, Bollag W, Isales C. Calcium ion as intracellular messenger and cellular toxin. Environ Health Perspect. 1990;84:17-25.
22. Bienenstock J, McDermott MR. Bronchus-and nasal-associated lymphoid tissues. Immunol Rev. 2005;206:22-31.