Five new C21 steroidal glycosides from the stems of Marsdenia tenacissima

Steroids

Volumn 75, Issue 2, 2010, Pages 176-183

  Zhang, Hua ^a   Tan, Ai Min ^a   Zhang, An Yuan ^a   Chen, Rong ^a   Yang, Shi Bao ^a   Huang, Xing ^a  

^a Jiangsu Simcere Pharmaceutical R and D Co Ltd   (China)

Author keywords

Cytotoxic activity; Marsdenia tenacissima; Steroidal glycosides

Indexed keywords

(3BETA,5ALPHA,12BETA,14BETA,17ALPHA) 3 BETA THEVETOPYRANOSYL(1-4) BETA OLEANDROPYRANOSYL(1-4) BETA CYMAROPYRANOSYL(1-4) BETA DIGITOXOPYRANOXY 8,14,17 TRIHYDROXYPREGNAN 20 ONE; (3BETA,5ALPHA,12BETA,14BETA,17ALPHA) 3 BETA THEVETOPYRANOSYL(1-4) BETA OLEANDROPYRANOSYL(1-4) BETA CYMAROPYRANOSYL(1-4) BETA DIGITOXOPYRANOXY 8,14,17,20 TETRAHYDROXYPREGNAN 12 YL BENZOATE; (3BETA,5ALPHA,12BETA,14BETA,17ALPHA) 3 BETA THEVETOPYRANOSYL(1-4) BETA OLEANDROPYRANOSYL(1-4) BETA CYMAROPYRANOSYL(1-4) BETA DIGITOXOPYRANOXY 8,14,17,20 TETRAHYDROXYPREGNAN 12 YL CINNAMATE; (3BETA,5ALPHA,12BETA,14BETA,17ALPHA) 3 BETA THEVETOPYRANOSYL(1-4) BETA OLEANDROPYRANOSYL(1-4) BETA CYMAROPYRANOSYL(1-4) BETA DIGITOXOPYRANOXY 8,14,17,20 TETRAHYDROXYPREGNAN 20 YL CINNAMATE; (3BETA,5ALPHA,12BETA,14BETA,17ALPHA) 3 BETA THEVETOPYRANOSYL(1-4) BETA OLEANDROPYRANOSYL(1-4) BETA DIGITOXOPYRANOSYL(1-4) BETA DIGITOXOPYRANOXY 8,14,17,20 TETRAHYDROXYPREGNAN 12 YL BENZOATE; CYTOTOXIC AGENT; GLYCOSIDE; PLANT EXTRACT; STEROID; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

ARTICLE; CANCER CELL CULTURE; CHEMICAL STRUCTURE; CONDURANGO; CONTROLLED STUDY; DRUG ISOLATION; DRUG MECHANISM; HUMAN; HUMAN CELL; MARSDENIA TENACISSIMA; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLANT STEM; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; ISOLATION AND PURIFICATION;

MARSDENIA TENACISSIMA;

ANTINEOPLASTIC AGENTS; CELL SURVIVAL; GLYCOSIDES; HUMANS; MARSDENIA; PLANT STEMS; STEROIDS;

EID: 73549087406     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2009.11.003     Document Type: Article

References (9)

1. Luo S.Q., Lin L.Z., Cabrera G., Liang X., and Johnson M.E. Polyoxypregnanes from Marsdenia tenacissima. Phytochemistry 34 6 (1993) 1615-1620
2. Shobha S., Maheshwari P.K., Anakshi K., and Cissogenin. A pregnane genin from Marsdenia tenacissima. Phytochemistry 19 (1980) 2427-2430
3. Shuji M., Kimiko Y., Koji H., Koh K., and Hiroshi M. Five glycosides from Chinese drug 'Tong-Guang-San': the stems of Marsdenia tenacissima. Phytochemistry 25 12 (1986) 2861-2865
4. Xia Z.H., Xing W.X., Mao S.L., Lao A.N., Uzawa J., Yoshida S., et al. Pregnane glycosides from the stems of Marsdenia tenacissima. J Asian Nat Prod Res 6 2 (2004) 79-85
5. Deng J., Liao Z.X., and Chen D.F. Marsdenosides A-H, polyoxypregnane glycosides from Marsdenia tenacissima. Phytochemistry 66 (2005) 1040-1051
6. Wang X.L., Li Q.F., Yu K.B., Peng S.L., Zhou Y., and Ding L.S. Four new pregnane glycosides from the stems of Marsdenia tenacissima. Helv Chim Acta 89 11 (2006) 2738-2744
7. Ruan J.L., Wang J.Y., and Ding W.P. Structure determination of marsdekoiside E. Chin Pharm J 28 4 (1993) 213-215
8. Tsutomu W., and Tadataka N. Steroidal glycosides from the aerial part of Asclepias incarnata L. II. Chem Pharm Bull 48 1 (2000) 99-107
9. Zhang H., Tan A.M., Feng F., Yang S.B., Zhang A.Y., and Huang X. Two new C21 steroidal glycosides from the stems of Marsdenia tenacissima. Helv Chim Acta 91 8 (2008) 1489-1493