Impaired wound healing in mice lacking the basement membrane protein nidogen 1

Matrix Biology

Volumn 29, Issue 1, 2010, Pages 15-21

  Baranowsky, Anke ^a   Mokkapati, Sharada ^a   Bechtel, Manuela ^a   Krügel, Jenny ^b   Miosge, Nicolai ^b   Wickenhauser, Claudia ^a   Smyth, Neil ^c   Nischt, Roswitha ^a  

^a UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Basement membrane; Epidermal differentiation; Nidogen 1 deficient mice; Nidogen 2; Skin; Wound repair

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA1 INTEGRIN; BETA4 INTEGRIN; COLLAGEN TYPE 4; ENTACTIN; LAMININ; MEMBRANE PROTEIN; PERLECAN;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DERMIS; DERMOEPIDERMAL JUNCTION; EPIDERMIS; EPITHELIZATION; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SKIN INJURY; ULTRASTRUCTURE; WOUND CLOSURE; WOUND HEALING; WOUND HEALING IMPAIRMENT;

ANIMALS; BASEMENT MEMBRANE; CELL DIFFERENTIATION; COLLAGEN TYPE IV; EPIDERMIS; FEMALE; GRANULATION TISSUE; INTEGRINS; INTERCELLULAR JUNCTIONS; LAMININ; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; WOUND HEALING;

MUS;

EID: 73449146600     PISSN: 0945053X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.matbio.2009.09.004     Document Type: Article

References (37)

1. Aumailley M., and Rousselle P. Laminins of the dermo-epidermal junction. Matrix Biol. 18 (1999) 19-28
2. Aumailley M., Battaglia C., Mayer U., Nischt R., Timpl R., and Fox J.W. Nidogen mediates the formation of ternary complexes of basement membrane components. Kidney Int. 43 (1993) 7-12
3. Aumailley M., El Khal A., Knoss N., and Tunggal L. Laminin 5 processing and its integration into the ECM. Matrix Biol. 22 (2003) 49-54
4. Bader B.L., Smyth N., Nedbal S., Miosge N., Baranowsky A., Mokkapati S., Murshed M., and Nischt R. Compund genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice. Mol. Cell. Biol. 25 (2005) 6846-6856
5. Borradori L., and Sonnenberg A. Structure and function of hemidesmosomes: more than simple adhesion complexes. J. Invest. Dermatol. 112 (1999) 411-418
6. Böse K., Nischt R., Page A., Bader B.L., Paulsson M., and Smyth N. Loss of nidogen-1 and -2 results in syndactyly and changes in limb development. J. Biol. Chem. 281 (2006) 39620-39629
7. Dedhar S., Jewell K., Roijani M., and Gray V. The receptor for the basement membrane glycoprotein entactin is the integrin alpha 3/beta 1. J. Biol. Chem. 267 (1992) 18908-18914
8. Dong L., Chen Y., Lewis M., Hsieh J.-C., Reing J., Chaillet J.R., Howell C.Y., Melhem M., Inoue S., Kiszak J.R., DeGeest K., and Chung A.E. Neurologic defects and selective disruption of basement membranes in mice lacking entactin-1/nidogen-1. Lab. Invest. 82 (2002) 1617-1630
9. Fox J.W., Mayer U., Nischt R., Aumailley M., Reinhardt D., Wiedemann H., Mann K., Timpl R., Krieg T., Engel J., and Chu M.-L. Recombinant nidogen consists of three globular domains and mediates binding of laminin to collagen IV. EMBO J. 10 (1991) 3137-3146
10. Gerharz M., Baranowsky A., Siebolts U., Eming E., Nischt R., Krieg T., and Wickenhauser C. Morphometric analysis of murine skin wound healing: standardization of experimental procedures and impact of an advanced multitissue array technique. Wound Repair Regen. 15 (2007) 105-112
11. Goldfinger L.E., Stack M.S., and Jones S.C. Processing of laminin-5 and its functional consequences: role of plasmin and tissue-type plasminogen activator. J. Cell Biol. 141 (1998) 255-265
12. Goldfinger L.E., Hopkinson S.B., deHart G.W., Collwan S., Couchman J.R., and Jones J.C. The alpha3 laminin subunit, alpha6beta4 and alpha3beta1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin. J. Cell Sci. 112 (1999) 2615-2629
13. Ho M.S., Böse K., Mokkapati S., Nischt R., and Smyth N. Nidogens-extracellular matrix linker molecules. Microsc. Res. Tech. 71 (2008) 387-395
14. Kikkawa Y., Yu H., Genersch E., Sanzen N., Sekiguchi K., Fässler R., Campbell K.P., Talts J.F., and Ekblom P. Laminin isoforms differentially regulate adhesion, spreading, proliferation, and ERK activation of beta1 integrin-null cells. Exp. Cell Res. 300 (2004) 94-108
15. Kimura N., Toyoshima T., Kojima T., and Shimane M. Entactin-2: a new basement membrane protein with high homology to entactin/nidogen. Exp. Cell Res. 241 (1998) 36-45
16. Kohfeldt E., Sasaki T., Göhring W., and Timpl R. Nidogen-2: a new basement membrane protein with diverse binding properties. J. Mol. Biol. 282 (1998) 99-109
17. Li J., Tzu T., Chen Y., Zhang Y.P., Nguyen N.T., Gao J., Bradley M., Keene D.R., Oro A.E., Miner J.H., and Marinkovich M.P. Laminin-10 is crucial for hair morphogenesis. EMBO J. 22 (2003) 2400-2410
18. Litjens S.H., de Pereda J.M., and Sonnenberg A. Current insights into the formation and breakdown of hemidesmosomes. Trends Cell Biol. 16 (2006) 376-383
19. Mann K., Deutzmann R., Aumailley M., Timpl R., Raimondi L., Yamamda Y., Pan T., Conway D., and Chu M.L. Amino acid sequence of mouse nidogen, a multidomain basement membrane protein with binding activity for laminin, collagen IV and cells. EMBO J. 12 (1989) 1879-1885
20. Martin P. Wound healing-aiming for perfect skin regeneration. Science 276 (1997) 75-81
21. McKee K.K., Harrison D., Capicci S., and Yurchenco P.D. Role of laminin terminal globular domains in basement membrane assembly. J. Biol. Chem. 282 (2007) 21437-21447
22. McKee K.K., Capicci S., and Yurchenco P.D. Scaffold-forming and adhesive contributions of synthetic laminin-binding proteins to basement membrane assembly. J. Biol. Chem. 284 (2009) 8984-8994
23. Miosge N., Klenczar C., Herken R., Willem M., and Mayer U. The organization of the myotendenous junction is dependent on the presence of 71 integrin. Lab. Invest. 79 (1999) 1591-1599
24. Miosge N., Sasaki T., and Timpl R. Evidence of nidogen-2 compensation for nidogen-1 deficiency in transgenic mice. Matrix Biol. 21 (2002) 611-621
25. Mokkapati S., Baranowsky A., Mirancea N., Smyth N., Breitkreutz D., and Nischt R. Basement membranes in skin are differently affected by lack of nidogen 1 and 2. J. Invest. Dermatol. 128 (2008) 2259-2267
26. Murshed M., Smyth N., Miosge N., Karolat J., Krieg T., Paulsson M., and Nischt R. The absence of nidogen-1 does not affect murine basement membrane development. Mol. Cell. Biol. 20 (2000) 7007-7012
27. Nguyen B.P., Ryan M.C., Gil S.G., and Carter W.G. Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion. Curr. Opin. Cell Biol. 12 (2000) 554-562
28. Nischt R., Schmidt C., Mirancea N., Baranowsky A., Mokkapati S., Smyth N., Woenne E.C., Stark H.J., Boukamp P., and Breitkreutz D. Lack of nidogen-1 and -2 prevents basement membrane assembly in skin-organotypic coculture. J. Invest. Dermatol. 127 (2007) 545-554
29. Raymond K., Kreft M., Janssen H., Calafat J., and Sonnenberg A. Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice. J. Cell Sci. 118 (2005) 1045-1060
30. Salmirvirta K., Talts J.F., Olsson M., Sasaki T., Timpl R., and Ekblom P. Binding of mouse nidogen-2 to basement membrane components and cells and its expression in embryonic and adult tissues suggest complementary functions of the two nidogen isoforms. Exp. Cell Res. 279 (2002) 188-201
31. Schymeinsky J., Nedbal S., Miosge N., Pöschl E., Rao C., Beier R.C., Skarnes W.C., Timpl R., and Bader B. Gene structure and functional analysis of the mouse nidogen-2 gene: nidogen-2 is not essential for basement membrane formation in mice. Mol. Cell. Biol. 22 (2002) 6820-6830
32. Smola H., Stark H.J., Thiekötter G., Mirancea N., Krieg T., and Fusenig N.J. Dynamics of basement membrane formation by keratinocyte-fibroblast interactions in organotypic skin cultures. Exp. Cell Res. 239 (1998) 399-410
33. Sugawara K., Tsuruta D., Ishii M., Jones J.C.R., and Kobayashi H. Laminin-332 and -511 in skin. Exp. Dermatol. 17 (2008) 473-480
34. Vasudevan A., Ho M.S., Weiergräber M., Nischt R., Schneider T., Lie A., Smyth N., and Köhling R. Basement membrane protein nidogen-1 shapes hippocampal synaptic plasticity and excitability. Hippocampus (2009) Electronic publication ahead of print
35. Werner S., and Grose R. Regulation of wound healing by growth factors and cytokines. Physiol. Rev. 83 (2003) 835-870
36. Willem M., Miosge N., Halfter W., Smyth N., Jannetti I., Burghart E., Timpl R., and Mayer U. Specific ablation of the nidogen-binding site in the laminin 1 chain interferes with kidney and lung development. Development 129 (2002) 2711-2722
37. Yurchenco P.D., Amenta P.S., and Patton B.L. Basement membrane assembly, stability and activities observed through a development lens. Matrix Biol. 22 (2004) 521-538