Heritability of Trail Making Test performance in multiplex schizophrenia families: Implications for the search for an endophenotype

European Archives of Psychiatry and Clinical Neuroscience

Volumn 259, Issue 8, 2009, Pages 475-481

  Quiñones, Raúl Mendoza ^a   Calderín, Yuranny Cabral ^a   Domínguez, Mayelin ^a   Bravo, Tania M ^a   Berazaín, Adnelys Reyes ^a   García, Alexander ^a   Caballero, Antonio ^b   Reyes, Migdyrai Martín ^a  

^a Cuban Neurosciences Center   (Cuba)

^b Department of Psychiatry   (Cuba)

Author keywords

Executive functions; Heritability; Schizophrenia; Trail Making Test

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; CONTROLLED STUDY; FAMILY HEALTH; FEMALE; GENETIC PREDISPOSITION; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PSYCHOLOGIC TEST; SCHIZOPHRENIA; TASK PERFORMANCE;

ADOLESCENT; ADULT; AGED; ANALYSIS OF VARIANCE; COGNITION DISORDERS; EXECUTIVE FUNCTION; FAMILY; FEMALE; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; TRAIL MAKING TEST; YOUNG ADULT;

EID: 73449140486     PISSN: 09401334     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00406-009-0012-6     Document Type: Article

References (41)

1. A Aleman R Hijman EH de Haan RS Kahn 1999 Memory impairment in schizophrenia: a meta-analysis Am J Psychiatry 156 9 1358 1366 1:STN:280:DyaK1MvhsVKjsw%3D%3D 10484945
2. L Almasy J Blangero 1998 Multipoint quantitative-trait linkage analysis in general pedigrees Am J Hum Genet 62 1198 1211 10.1086/301844 1:STN:280:DyaK1c3htlGrtg%3D%3D 9545414 (Pubitemid 28199022)
3. American Psychiatric Association (1984) Diagnostic and statistical manual of mental disorder, 4th edn. American Psychiatry Association, Washington
4. AP Anokhin A Heath A Ralano 2003 Genetic influences on frontal brain function: WCST performance in twins Neuroreport 14 15 1975 1978 10.1097/00001756-200310270-00019 14561932 (Pubitemid 38339772)
5. K Arbuthnott J Frank 2000 Trail Making Test, part B as a measure of executive control: validation using a set-switching paradigm J Clin Exp Neuropsychol 22 4 518 528 10.1076/1380-3395(200008)22:4;1-0;FT518 1:STN:280:DC%2BD3cvnt1yhsw%3D%3D 10923061
6. RF Asarnow KH Nuechterlein KL Subotnik DL Fogelson RD Torquato DL Payne J Asamen J Mintz D Guthrie 2002 Neurocognitive impairments in nonpsychotic parents of children with schizophrenia and attention-deficit/hyperactivity disorder: the University of California, Los Angeles Family Study Arch Gen Psychiatry 59 1053 1060 10.1001/archpsyc.59.11.1053 12418939 (Pubitemid 35285505)
7. MF Aukes BZ Alizadeh MM Sistkoorn J Selten RJ Sinke C Kemmer RA Ophoff RS Kahn 2008 Finding suitable phenotypes for genetic studies of schizophrenia: heritability and segregation analysis Biol Psychiatry 64 2 128 136 10.1016/j.biopsych.2007.12.013 1:CAS:528:DC%2BD1cXnsFGitbs%3D 18295748
8. L Bonilha C Molnar MD Horner B Anderson L Forster MS George Z Nahas 2008 Neurocognitive deficits and prefrontal cortical atrophy in patients with schizophrenia Schizophr Res 101 142 151 10.1016/j.schres.2007.11.023 18164594
9. P Brazo P Delamillieure R Morello I Halbecq RM Marie S Dollfus 2005 Impairments of executive/attentional functions in schizophrenia with primary and secondary negative symptoms Psychiatry Res 133 45 55 10.1016/j.psychres.2004. 10.001 15698676 (Pubitemid 40215470)
10. BA Cornblatt AK Malhotra 2001 Impaired attention as an endophenotype for molecular genetic studies of schizophrenia Am J Med Genet 105 1 11 15 10.1002/1096-8628(20010108)105:1<11::AID-AJMG1045>3.0.CO;2-G 1:STN:280:DC%2BD3Mzmtleiug%3D%3D 11424979 (Pubitemid 32105185)
11. S Dollfus C Lombardo K Benali I Halbecq P Abadie RM Marie P Brazo 2002 Executive/attentional cognitive functions in schizophrenic patients and their parents: a preliminary study Schizophr Res 1 53 93 99 10.1016/S0920-9964(01) 00156-6 (Pubitemid 33139779)
12. MF Egan TE Goldberg T Gscheidle M Weirich R Rawlings TM Hyde L Bigelow DR Weinberger 2001 Relative risk for cognitive impairments in siblings of patients with schizophrenia Biol Psychiatry 50 98 107 10.1016/S0006-3223(01)01133-7 1:STN:280:DC%2BD3MvosVOjug%3D%3D 11527000 (Pubitemid 32728209)
13. P Franke W Maier J Hardt C Hain 1993 Cognitive functioning and anhedonia in subjects at risk for schizophrenia Schizophr Res 10 77 84 10.1016/0920-9964(93)90079-X 1:STN:280:DyaK3sznvVyrsA%3D%3D 8369235 (Pubitemid 23211841)
14. CM Gilvarry A Rusell D Hemsley RM Murray 2000 Trail Making Test performance in the first degree relatives of schizophrenic and affected psychotic patients Cogn Neuropsychiatry 5 219 234 10.1080/13546800050083548
15. C González-Blanch M Álvarez-Jiménez JM Rodríguez-Sánchez R Pérez-Iglesias JL Vázquez- Barquero B Crespo-Facorro 2006 Cognitive functioning in the early course of first-episode schizophrenia spectrum disorders Eur Arch Psychiatry Clin Neurosci 256 364 371 10.1007/s00406-006-0646-6 16788772 (Pubitemid 44393004)
16. II Gottesman TD Gould 2003 The endophenotype concept in psychiatry: etymology and strategic intentions Am J Psychiatry 160 636 645 10.1176/appi.ajp.160.4.636 12668349 (Pubitemid 41079594)
17. RW Heinrich KK Zakzanis 1998 Neurocognitive deficit in schizophrenia: a quantitative review of the evidence Neuropsychology 12 426 445 10.1037/0894-4105.12.3.426 (Pubitemid 28323862)
18. RS Keefe JM Silverman SE Roitman PD Harvey MA Duncan D Alroy LJ Siever KL Davis RC Mohs 1994 Performance of nonpsychotic relatives of schizophrenic patients on cognitive tests Psychiatry Res 53 1 12 10.1016/0165-1781(94)90091-4 1:STN:280:DyaK2M%2FotlOquw%3D%3D 7991726 (Pubitemid 24266117)
19. WS Kremen LJ Seidman JR Pepple MJ Lyons MT Tsuang SV Faraone 1994 Neuropsychological risk indicators for schizophrenia: a review of family studies Schizophr Bull 20 1 103 119 1:STN:280:DyaK2c3lsFOisQ%3D%3D 8197409
20. X Ma Q Wang PC Sham X Liu S Rabe-Hesketh X Sun J Hu H Meng W Chen EYH Chen W Deng RCK Chan R Murray D Collier T Li 2007 Neurocognitive deficits in first-episode schizophrenic patients and their first-degree relatives Am J of Med Genet B Neuropsychiatr Genet 144B 407 416 10.1002/ajmg.b.30330 (Pubitemid 46983146)
21. Maxwell ME (1992) Family interview for genetic studies. Clinical Neurogenetic Branch, Intramural Research Program, NIMH
22. A Meyer-Lindenberg JB Poline PD Kohn JL Holt MF Egan DR Weinberger KF Berman 2001 Evidence for abnormal cortical functional connectivity during working memory in schizophrenia Am J Psychiatry 158 1809 1817 10.1176/appi.ajp.158.11.1809 1:STN:280:DC%2BD3MnktVemsA%3D%3D 11691686 (Pubitemid 33054773)
23. C Pantelis FZ Barber TRE Barnes HE Nelson SM Owen TW Robbins 1999 Comparison of set-shifting ability in patients with chronic schizophrenia and frontal lobe damage Schizophr Res 37 3 251 270 10.1016/S0920-9964(98)00156-X 1:STN:280:DyaK1MzivF2qsw%3D%3D 10403197 (Pubitemid 29298095)
24. JA Periáñez M Ríos-Lago JM Rodríguez- Sánchez D Adrover-Roig I Sánchez-Cubillo B Cresco-Facorro JL Quemada F Barceló 2007 Trail Making in traumatic brain injury, schizophrenia, and normal ageing: sample comparisons and normative data Arch Clin Neuropsychol 22 433 447 10.1016/j.acn.2007.01.022 17336493 (Pubitemid 46810180)
25. MF Pogue-Geile AH Garrett JJ Brunke JK Hall 1991 Neuropsychological impairments are increased in siblings of schizophrenic patients Schizophr Res 4 390 10.1016/0920-9964(91)90332-L
26. RM Reitan 1958 Validity of Trail Making Test as an indicator of organic brain damage Percept Mot Skills 8 271 276 10.2466/PMS.8.7.271-276
27. M Riedel I Spellmann M Strassnig A Douhet S Dehning M Opgen-Rhein R Valdevit R Engel N Kleindienst N Müller H Möller 2007 Effects of risperidone and quetiapine on cognition in patients with schizophrenia and predominantly negative symptoms Eur Arch Psychiatry Clin Neurosci 257 360 370 10.1007/s00406-007-0739-x 17629731 (Pubitemid 47476724)
28. LM Ritter JH Meador-Woodruff GW Dalack 2004 Neurocognitive measures of prefrontal cortical dysfunction in schizophrenia Schizophr Res 68 65 73 10.1016/S0920-9964(03)00086-0 15037340 (Pubitemid 38368137)
29. MM Sitskoorn A Aleman SJH Ebisch MCM Apples RS Kahn 2004 Cognitive deficits in relatives of patients with schizophrenia: a meta-analysis Schizophr Res 71 285 295 10.1016/j.schres.2004.03.007 15474899 (Pubitemid 39330506)
30. BE Snitz AW Macdonald CS Carter 2006 Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes Schizophr Bull 32 179 194 10.1093/schbul/sbi048 16166612 (Pubitemid 43063833)
31. I Spellmann N Müller R Musil P Zill A Douhet S Dehning A Cerovecki B Bondy H Möller M Riedel 2008 Associations of SNAP-25 polymorphisms with cognitive dysfunctions in Caucasian patients with schizophrenia during a brief trail of treatment with atypical antipsychotics Eur Arch Psychiatry Clin Neurosci 258 335 344 10.1007/s00406-007-0800-9 18347838
32. GE Swan D Carmelli 2002 Evidence for genetic mediation of executive control: a study of aging male twins J Gerontol B Psychol Sci Soc Sci 57 133 143
33. A Szöke F Schurhoff F Mathieu A Meary S Ionescu M Leboyer 2005 Tests of executive functions in first-degree relatives of schizophrenic patients: a meta-analysis Psychol Med 35 771 782 10.1017/S0033291704003460 15997598 (Pubitemid 40873378)
34. J Taylor 2007 Heritability of Wisconsin Card Sorting Test (WCST) and Stroop Color-Word Test performance in normal individuals: implications for the search for endophenotypes Twin Res Hum Genet 10 6 829 834 10.1375/twin.10.6.829 18179394 (Pubitemid 350292296)
35. JL Thompson JR Watson SR Steinhauer G Goldstein MF Pogue-Geile 2005 Indicators of genetic liability to schizophrenia: a sibling study of neuropsychological performance Schizophr Bull 31 1 85 96 10.1093/schbul/sbi009 15888428 (Pubitemid 41214359)
36. A Tuulio-Henriksson J Haukka T Partonen T Varilo T Paunio J Ekelund TD Cannon J Lönnqvist 2002 Heritability of neurocognitive functions and number of quantitative trait loci contributing to them in families with schizophrenia Am J Med Genet B Neuropsychiatr Genet 114 483 490 10.1002/ajmg.10480 (Pubitemid 34680572)
37. Vázquez-Barquero JL (1992) Report on the Spanish Translation of the SCAN, Schedules and Glossary. Informe a la Organización Mundial de la Salud. Unidad de Investigación en Psiquiatría Social de Cantabria, Santander
38. DI Velligan M DiCocco CC Bow-Thomas C Cadle DC Glahn AL Miller MM Bigg K Shores-Wilson CA McKenzie ML Crismon 2004 A brief cognitive assessment for use with schizophrenia patients in community clinics Schizophr Res 71 273 283 10.1016/j.schres.2004.02.027 15474898 (Pubitemid 39330505)
39. ID Waldman 2005 Statistical approaches to complex phenotypes: evaluating neuropsychological endophenotypes for attention-deficit/hyperactivity disorder Biol Psychiatry 57 1347 1356 10.1016/j.biopsych.2005.03.002 15950007 (Pubitemid 40798554)
40. DA Yurgelun-Todd DK Kinney 1993 Patterns of neuropsychological deficits that discriminate schizophrenic individuals from siblings and control subjects J Neuropsychiatry 5 294 300 1:STN:280:DyaK3sznvFCmuw%3D%3D
41. T Zalla C Joyce A Szoke F Schurhoff B Pillon O Komano F Perez-Diaz F Bellivier C Alter B Duboise F Rouillon O Houde M Leboyer 2004 Executive dysfunctions as potential markers of familial vulnerability to bipolar disorder and schizophrenia Psychiatry Res 121 207 217 10.1016/S0165-1781(03)00252-X 14675740 (Pubitemid 37522174)