A randomized controlled study of weekly and biweekly dosing of epoetin alfa in CKD patients with anemia

Clinical Journal of the American Society of Nephrology

Volumn 4, Issue 11, 2009, Pages 1731-1740

  Pergola, Pablo E ^a   Gartenberg, Gary ^b   Fu, Min ^b   Wolfson, Marsha ^c   Rao, Sudhakar ^b   Bowers, Peter ^b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^c CENTOCOR INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; IRON; RECOMBINANT ERYTHROPOIETIN;

ACUTE CORONARY SYNDROME; ACUTE KIDNEY FAILURE; ADULT; AGED; ANEMIA; ARTERY EMBOLISM; ARTERY THROMBOSIS; ARTICLE; CEREBROVASCULAR ACCIDENT; CHRONIC KIDNEY DISEASE; CHRONIC KIDNEY FAILURE; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DEHYDRATION; DIARRHEA; DOSAGE SCHEDULE COMPARISON; DRUG EFFICACY; DRUG RESPONSE; DRUG WITHDRAWAL; DYSPNEA; ERYTHROCYTE TRANSFUSION; FALLING; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEART INFARCTION; HEMOGLOBIN BLOOD LEVEL; HIP FRACTURE; HUMAN; HYPOGLYCEMIA; MAJOR CLINICAL STUDY; MALE; MORBIDITY; OSTEOARTHRITIS; PNEUMONIA; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SYNCOPE; THORAX PAIN; URINARY TRACT INFECTION;

ADULT; AGED; AGED, 80 AND OVER; ANEMIA; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOETIN ALFA; ERYTHROCYTE TRANSFUSION; FEMALE; HEMATINICS; HEMOGLOBINS; HUMANS; HYPERTENSION, RENAL; INCIDENCE; IRON; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; MORBIDITY; RENAL DIALYSIS; THROMBOEMBOLISM; TREATMENT OUTCOME;

EID: 73449135779     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.03470509     Document Type: Article

References (23)

1. Astor BC, Muntner P, Levin A, Eustace JA, Coresh J: Association of kidney function with anemia: The Third National Health and Nutrition Examination Survey (1988-1994). Arch Intern Med 162: 1401-1408, 2002
2. Teehan BP, Benz RL, Sigler MH, Brown JM: Early intervention with recombinant human erythropoietin therapy. Semin Nephrol 10: 28-34, 1990
3. Levin A, Singer J, Thompson CR, Ross H, Lewis M: Prevalent left ventricular hypertrophy in the predialysis population: identifying opportunities for intervention. Am J Kidney Dis 27: 347-354, 1996
4. Silverberg DS, Wexler D, Blum M, Keren G, Sheps D, Leibovitch E, Brosh D, Laniado S, Schwartz D, Yachnin T, Shapira I, Gavish D, Baruch R, Koifman B, Kaplan C, Steinbruch S, Iaina A: The use of subcutaneous erythropoietin and intravenous iron for the treatment of the anemia of severe, resistant congestive heart failure improves cardiac and renal function and functional cardiac class, and markedly reduces hospitalizations. J Am Coll Cardiol 35: 1737-1744, 2000
5. Pickett JL, Theberge DC, Brown WS, Schweitzer SU, Nissenson AR: Normalizing hematocrit in dialysis patients improves brain function. Am J Kidney Dis 33: 1122-1130, 1999
6. McClellan W, Aronoff SL, Bolton WK, Hood S, Lorber DL, Tang KL, Tse TF, Wasserman B, Leiserowitz M: The prevalence of anemia in patients with chronic kidney disease. Curr Med Res Opin 20: 1501-1510, 2004
7. Revicki DA, Brown RE, Feeny DH, Henry D, Teehan BP, Rudnick MR, Benz RL: Health-related quality of life associated with recombinant human erythropoietin therapy for predialysis chronic renal disease patients. Am J Kidney Dis 25: 548-554, 1995
8. Kuriyama S, Tomonari H, Yoshida H, Hashimoto T, Kawaguchi Y, Sakai O: Reversal of anemia by erythropoietin therapy retards the progression of chronic renal failure, especially in nondiabetic patients. Nephron 77: 176-185, 1997
9. Jungers P, Choukroun G, Oualim Z, Robino C, Nguyen AT, Man NK: Beneficial influence of recombinant human erythropoietin therapy on the rate of progression of chronic renal failure in predialysis patients. Nephrol Dial Transplant 16: 307-312, 2001
10. Nissenson AR: Novel erythropoiesis stimulating protein for managing the anemia of chronic kidney disease. Am J Kidney Dis 38: 1390-1397, 2001
11. Maxwell AP: Novel erythropoiesis-stimulating protein in the management of the anemia of chronic renal failure. Kidney Int 62: 720-729, 2002
12. McGowan T, Vaccaro NM, Beaver JS, Massarella J, Wolfson M: Pharmacokinetic and pharmacodynamic profiles of extended dosing of epoetin alfa in anemic patients who have chronic kidney disease and are not on dialysis. Clin J Am Soc Nephrol 3: 1006-1014, 2008
13. K-DOQI Working Group Members: IV. NKF-K/DOQI Clinical Practice Guidelines for Anemia of Chronic Kidney Disease: Update 2000. Am J Kidney Dis 37: S182-S238, 2001
14. PROCRIT Prescribing Information [online]. Available at: www.procrit.com. Accessed April 20, 2009
15. Spinowitz B, Germain M, Benz R, Wolfson M, McGowan T, Tang KL, Kamin M: A randomized study of extended dosing regimens for initiation of epoetin alfa treatment for anemia of chronic kidney disease. Clin J Am Soc Nephrol 3: 935-937, 2008
16. Piccoli A, Malagoli A, Komninos G, Pastori G: Subcutaneous epoetin-alfa every one, two, and three weeks in renal anemia. J Nephrol 15: 565-574, 2002
17. Provenzano R, Bhaduri S, Singh AK, Group PS: Extended epoetin alfa dosing as maintenance treatment for the anemia of chronic kidney disease: the PROMPT study. Clin Nephrol 64: 113-123, 2005
18. Lim VS, Kirchner PT, Fangman J, Richmond J, DeGowin RL: The safety and the efficacy of maintenance therapy of recombinant human erythropoietin in patients with renal insufficiency. Am J Kidney Dis 14: 496-506, 1989
19. Provenzano R, Garcia-Mayol L, Suchinda P, Von Hartitzsch B, Woollen SB, Zabaneh R, Fink JC, Group PS: Once-weekly epoetin alfa for treating the anemia of chronic kidney disease. Clin Nephrol 61: 392-405, 2004
20. Benz R, Schmidt R, Kelly K, Wolfson M: Epoetin alfa once every 2 weeks is effective for initiation of treatment of anemia of chronic kidney disease. Clin J Am Soc Nephrol 2: 215-221, 2007
21. Germain M, Ram CV, Bhaduri S, Tang KL, Klausner M, Curzi M: Extended epoetin alfa dosing in chronic kidney disease patients: A retrospective review. Nephrol Dialysis Transplant 20: 2146-2152, 2005
22. Locatelli F, Olivares J, Walker R, Wilkie M, Jenkins B, Dewey C, Gray SJ: Novel erythropoiesis stimulating protein for treatment of anemia in chronic renal insufficiency. Kidney Int 60: 741-747, 2001
23. Macdougall IC, Walker R, Provenzano R, de Alvaro F, Locay HR, Nader PC, Locatelli F, Dougherty FC, Beyer U: C.E.R.A. corrects anemia in patients with chronic kidney disease not on dialysis: Results of a randomized clinical trial. Clin J Am Soc Nephrol 3: 337-347, 2008