The Auxiliary Substrate Concept: From simple considerations to heuristically valuable knowledge

Engineering in Life Sciences

Volumn 9, Issue 4, 2009, Pages 285-290

  Babel, Wolfgang ^a  

^a HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH UFZ   (Germany)

Author keywords

Auxiliary substrate; Energetic evaluation; Upper limit; Yield coefficient

Indexed keywords

CARBON CONVERSIONS; CARBON METABOLISM; ENERGY SOURCE; HEXADECANE; INORGANICS; MIXING RATIOS; ORGANICS; SCIENTISTS AND ENGINEERS; SECONDARY METABOLISM; SIMULTANEOUS UTILIZATION; SINGLE CELL PROTEINS; UPPER LIMIT; UPPER LIMITS; YIELD COEFFICIENT;

CATALYSTS; CONVERSION EFFICIENCY; DETOXIFICATION; GLUCOSE; METABOLISM; METHANOL; PARAFFINS; PROTEINS;

SUBSTRATES;

ACETIC ACID; ADENOSINE TRIPHOSPHATE; FORMIC ACID; GLUCOSE; HEXADECANE; METHANOL; THIOSULFATE;

BIOTECHNOLOGY; CATALYST; DATA ASSIMILATION; HEURISTICS; MICROORGANISM; MIXING RATIO;

BIOSYNTHESIS; BIOTECHNOLOGY; CARBON FIXATION; CARBON SOURCE; ENERGY METABOLISM; GLUCONEOGENESIS; GLYCOLYSIS; MICROBIAL GROWTH; MICROORGANISM; MOLECULAR GENETICS; NONHUMAN; SHORT SURVEY;

EID: 73449129351     PISSN: 16180240     EISSN: 16182863     Source Type: Journal    
DOI: 10.1002/elsc.200900027     Document Type: Short Survey

References (30)

1. W. J. Payne, Energy yields and growth of heterotrophs. Ann. Rev. Microbiol. 1970, 24, 17-52.
2. J. G. J. Dekkers, H. E. de Kok, J. A. Roels, Energetics of Saccharomyces cerevisiae CBS 426: comparison of anaerobic and anaerobic glucose limitation. Biotechnol. Bioeng. 1981, 23, 1023-1035.
3. J. M. Lebeault, Alkanes and highly reduced substrates for bacterial and yeast growth, in DECHEMA Monographie 83, No. 1704-1723, Verlag Chemie, Weinheim 1979, 135-145.
4. J. A. Roels, Energetics and Kinetics in Biotechnology. Elsevier Biomedical Press, Amsterdam, New York, Oxford, 1983.
5. E. H. Battley, Energetics of Microbial Growth. John Wiley & Sons, New York, Chichester, Brisbane, Toronto, Singapore, 1987.
6. J. Nielson, J. Villadsen, G. Liden, Bioreaction Engineering Principles. Kluwer Academic/Plenum Publishers, New York, Boston, Dordrecht, London, Moscow, 2003.
7. J. D. Linton, R. J. Stephenson, A preliminary study on growth yields in relation to the carbon and energy content of various organic growth substrates. FEMS Microbiol. Lett. 1978, 3, 95-98.
8. W. Babel, Bewertung von Substraten für das mikrobielle Wachstum auf der Grundlage ihres Kohlenstoff/Energie-Verhältnisses. Z. Allg. Mikrobiol. 1979, 19, 671-677.
9. A. H. Stouthamer, H. D. van Verseveld, Stoichiometry of microbial growth, in Comprehensive Biotechnology, Vol. 1 (Ed: M. Moo-Young). Pergamon Press, Oxford, New York, Toronto, Sydney, Frankfurt, 1985, 215-238.
10. P. J. F. Gommers, B. J. van Schie, J. P. van Dijken, J. G. Kuenen, Biochemical limits of microbial growth yields: an analysis of mixed substrate utilization. Biotechnol. Bioeng. 1988, 32, 86-94.
11. W. Babel, R. H. Müller, Correlation between cell composition and carbon conversion efficiency in microbial growth: a theoretical study. Appl. Microbiol. Biotechnol. 1985, 22, 201-207.
12. W. Babel, R. H. Müller, Microorganisms as catalysts for the decontamination of ecosystems and detoxification of chemicals, in Encyclopedia of Life Support Systems. EOLSS Publ., Oxford, UK, 2002. http://www.eolss.net
13. W. Babel, U. Brinkmann, R. H. Müller, The auxiliary substrate concept - an approach for overcoming limits of microbial performances. Acta Biotechnol. 1993, 13, 211-242.
14. A. H. Stouthamer, A theoretical study on the amount of ATP required for the synthesis of microbial cell material. Antonie v. Leeuwenhoek 1973, 39, 545-565.
15. J. P. van Dijken,W. Harder, Growth yields of microorganisms on methanol and methane: a theoretical study. Biotechnol. Bioeng. 1975, 17, 15-30.
16. C. Anthony, The prediction of growth yields in methylotrophs. J. Gen. Microbiol. 1978, 104, 91-104.
17. W. Babel, Effizienz und Geschwindigkeit von Wachstum und Vermehrung, in Physiologie der Mikroorganismen: Die Zelle, ihre Umwelt und die Mechanismen der Adaptation (Ed: M. Hecker, W. Babel). Gustav Fischer Verlag, Jena, Stuttgart, 1988, 72-92.
18. L. Dijkhuizen, W. Harder, Regulation of autotrophic and heterotrophic metabolism in Pseudomonas oxalaticus OX1. Growth on mixtures of acetate and formate in continuous culture. Arch. Microbiol. 1979, 123, 47-53.
19. J. D. Linton, K. Griffiths, M. Gregory, The effect of mixtures of glucose and formate on the yield and respiration of a chemostat culture of Beneckea natriegens. Arch. Microbiol. 1981, 129, 119-122.
20. H. D. van Verseveld, A. H. Stouthamer, Two-(carbon) substrate limited growth of Paracoccus denitrificans on mannitol and formate. FEMS Microbiol. Lett. 1980, 7, 207-211.
21. R. H. Müller,W. Babel, Glucose as an energy donor in acetate growing Acinetobacter calcoaceticus. Arch. Microbiol. 1986, 144, 62-66.
22. W. Babel, R. H. Müller, K.-D. Markuske, Improvement of growth yield of yeast on glucose to the maximum by using an additional energy source. Arch. Microbiol. 1983, 203-208.
23. P. M. Bruinenberg, R. Jonker, J. P. van Dijken, W. Scheffers, Utilization of formate as an additional energy source by glucose-limited chemostat cultures of Candida utilis CBS 621 and Saccharomyces cerevisiae CBS 8066: Evidence for the absence of transhydrogenase activity in yeasts. Arch. Microbiol. 1985, 142, 302-306.
24. R. H. Müller, W. Babel, Energy and reducing equivalent potential of C2 compounds for microbial growth. Acta Biotechnol. 1988, 8, 249-258.
25. R. H. Müller, W. Babel, Kontinuierliche nicht-fermentative Synthese von Aceton. Wiss. Z. Karl-Marx-Universität Leipzig; Math.-Nat.wiss. Reihe 1989, 38, 296-302.
26. W. Harder, L. Dijkhuizen, Strategies of mixed substrate utilization in microorganisms. Phil. Trans. R. Soc. Lond. 1982, B 297, 459-480.
27. T. Egli, The ecological and physiological significance of the growth of heterotrophic microorganisms with mixtures of substrates. Adv. Microb. Ecol. 1995, 14, 305-386.
28. U. Brinkmann, W. Babel, Simultaneous utilization of heterotrophic substrates by Hansenula polymorpha MH30 results in enhanced growth rates. Appl. Microbiol. Biotechnol. 1992, 37, 98-103
29. T. Bley, W. Babel, Calculating affinity constants of substrate mixtures in a chemostat. Acta Biotechnol. 1992, 12, 13-15.
30. F. P. Healey, Slope of the Monod equation as an indicator of advantage in nutrient competition. Microb. Ecol. 1980, 5, 281-286.