A new two-phase dimeticone pediculicide shows high efficacy in a comparative bioassay

BMC Dermatology

Volumn 9, Issue , 2009, Pages

  Heukelbach, Jorg ^a,b   Asenov, André ^c   Liesenfeld, Oliver ^c   Mirmohammadsadegh, Ali ^d   Oliveira, Fabíola A ^a,b  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b JAMES COOK UNIVERSITY   (Australia)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

'MOSQUITO'; CHLOROCRESOL; COCAMIDOPROPYL BETAINE; COCONUT OIL; COLLAGEN; DIETHYLENE GLYCOL; DIMETICONE; FRAGRANCE; GLYCINE; GLYCOSPHINGOLIPID; GOLDGEIST FORTE; INFECTOPEDICUL; LIBERALICE DUO LP PRO; MEDIUM CHAIN TRIACYLGLYCEROL; NYDA; NYDA SENSITIV; PERMETHRIN; PIPERONYL BUTOXIDE; PROPANOL; PROPYLENE GLYCOL; PYRETHROID; SHAMPOO; SODIUM DIHYDROGEN PHOSPHATE; SOYBEAN OIL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ARTICLE; BIOASSAY; CONTROLLED STUDY; DRUG EFFICACY; DRUG FORMULATION; EX VIVO STUDY; FEMALE; GERMANY; GLASS BOTTLE; IN VITRO STUDY; INSECTICIDAL ACTIVITY; MALE; MORTALITY; NONHUMAN; PEDICULUS; PLASTIC BOTTLE; VITAL SIGN; ANIMAL; CHILD; COMPARATIVE STUDY; DRUG EFFECT; HUMAN; PEDICULOSIS; SKIN DISEASE;

ANIMALS; BIOLOGICAL ASSAY; CHILD; DIMETHYLPOLYSILOXANES; HUMANS; LICE INFESTATIONS; PEDICULUS; SCALP DERMATOSES;

EID: 73449114257     PISSN: None     EISSN: 14715945     Source Type: Journal    
DOI: 10.1186/1471-5945-9-12     Document Type: Article

References (32)

1. Falagas ME, Matthaiou DK, Rafailidis PI, Panos G, Pappas G. Worldwide prevalence of head lice. Emerg Infect Dis 2008, 14(9):1493-1494. 10.3201/eid1409.080368, 2603110, 18760032.
2. Heukelbach J, Wilcke T, Winter B, Feldmeier H. Epidemiology and morbidity of scabies and pediculosis capitis in resource-poor communities in Brazil. Br J Dermatol 2005, 153(1):150-156. 10.1111/j.1365-2133.2005.06591.x, 16029341.
3. Willems S, Lapeere H, Haedens N, Pasteels I, Naeyaert JM, De Maeseneer J. The importance of socio-economic status and individual characteristics on the prevalence of head lice in schoolchildren. Eur J Dermatol 2005, 15(5):387-392.
4. Kasai S, Ishii N, Natsuaki M, Fukutomi H, Komagata O, Kobayashi M, Tomita T. Prevalence of kdr-like mutations associated with pyrethroid resistance in human head louse populations in Japan. J Med Entomol 2009, 46(1):77-82. 10.1603/033.046.0110, 19198520.
5. Thomas DR, McCarroll L, Roberts R, Karunaratne P, Roberts C, Casey D, Morgan S, Touhig K, Morgan J, Collins F. Surveillance of insecticide resistance in head lice using biochemical and molecular methods. Arch Dis Child 2006, 91(9):777-778. 10.1136/adc.2005.091280, 2082909, 16774979.
6. Kristensen M, Knorr M, Rasmussen AM, Jespersen JB. Survey of permethrin and malathion resistance in human head lice populations from Denmark. J Med Entomol 2006, 43(3):533-538. 10.1603/0022-2585(2006)43[533:SOPAMR]2.0.CO;2, 16739412.
7. Vassena CV, Mougabure Cueto G, Gonzalez Audino P, Alzogaray RA, Zerba EN, Picollo MI. Prevalence and levels of permethrin resistance in Pediculus humanus capitis De Geer (Anoplura: Pediculidae) from Buenos Aires, Argentina. J Med Entomol 2003, 40(4):447-450. 10.1603/0022-2585-40.4.447, 14680109.
8. Durand R, Millard B, Bouges-Michel C, Bruel C, Bouvresse S, Izri A. Detection of pyrethroid resistance gene in head lice in schoolchildren from Bobigny, France. J Med Entomol 2007, 44(5):796-798. 10.1603/0022-2585(2007)44[796:DOPRGI]2.0.CO;2, 17915510.
9. Heukelbach J, Canyon DV, Oliveira FA, Muller R, Speare R. In vitro efficacy of over-the-counter botanical pediculicides against the head louse Pediculus humanus var capitis based on a stringent standard for mortality assessment. Med Vet Entomol 2008, 22(3):264-272. 10.1111/j.1365-2915.2008.00738.x, 18816275.
10. Mougabure CG, Zerba EN, Picollo MI. Permethrin-resistant head lice (Anoplura: Pediculidae) in Argentina are susceptible to spinosad. J Med Entomol 2006, 43(3):634-635. 10.1603/0022-2585(2006)43[634:PHLAPI]2.0.CO;2, 16739427.
11. Burgess IF, Lee PN, Matlock G. Randomised, controlled, assessor blind trial comparing 4% dimeticone lotion with 0.5% malathion liquid for head louse infestation. PLoS ONE 2007, 2(11):e1127. 10.1371/journal.pone.0001127, 2043492, 17987114.
12. Heukelbach J, Pilger D, Oliveira FA, Khakban A, Ariza L, Feldmeier H. A highly efficacious pediculicide based on dimeticone: randomized observer blinded comparative trial. BMC Infect Dis 2008, 8:115. 10.1186/1471-2334-8-115, 2553415, 18783606.
13. Oliveira FA, Speare R, Heukelbach J. High in vitro efficacy of Nyda® L, a pediculicide containing dimeticone. J Eur Acad Dermatol Venereol 2007, 21(10):1325-1329. 10.1111/j.1468-3083.2007.02258.x, 17958836.
14. Burgess IF, Lee PN, Brown CM. Randomised, controlled, parallel group clinical trials to evaluate the efficacy of isopropyl myristate/cyclomethicone solution against head lice. Pharm J 2008, 280:371.
15. Carpinella MC, Miranda M, Almiron WR, Ferrayoli CG, Almeida FL, Palacios SM. In vitro pediculicidal and ovicidal activity of an extract and oil from fruits of Melia azedarach L. J Am Acad Dermatol 2007, 56(2):250-256. 10.1016/j.jaad.2006.10.027, 17147968.
16. Jadhav V, Kore A, Kadam VJ. In-vitro pediculicidal activity of Hedychium spicatum essential oil. Fitoterapia 2007, 78(7-8):470-473. 10.1016/j.fitote.2007.02.016, 17618065.
17. Burgess IF, Brunton ER, Burgess NA. Clinical trial showing superiority of a coconut and anise spray over permethrin 0.43% lotion for head louse infestation, ISRCTN96469780. Eur J Pediatr 2009, 169(1):55-62. 10.1007/s00431-009-0978-0, 19343362.
18. Connolly M, Stafford KA, Coles GC, Kennedy CT, Downs AM. Control of head lice with a coconut-derived emulsion shampoo. J Eur Acad Dermatol Venereol 2009, 23(1):67-69. 10.1111/j.1468-3083.2008.02829.x, 18631276.
19. Strycharz JP, Yoon KS, Clark JM. A new ivermectin formulation topically kills permethrin-resistant human head lice (Anoplura: Pediculidae). J Med Entomol 2008, 45(1):75-81. 10.1603/0022-2585(2008)45[75:ANIFTK]2.0.CO;2, 18283945.
20. Burgess IF. Current treatments for pediculosis capitis. Curr Opin Infect Dis 2009, 22(2):131-136. 10.1097/QCO.0b013e328322a019, 19283911.
21. Burgess IF. The mode of action of dimeticone 4% lotion against head lice, Pediculus capitis. BMC Pharmacol 2009, 9:3. 10.1186/1471-2210-9-3, 2652450, 19232080.
22. Richling I, Böckeler W. Lethal Effects of Treatment with a Special Dimeticone Formula on Head Lice and House Crickets (Orthoptera, Ensifera: Acheta domestica and Anoplura, Phthiraptera: Pediculus humanus). Arzneimittelforschung 2008, 58(5):248-254.
23. Heukelbach J, Winter B, Wilcke T, Muehlen M, Albrecht S, Oliveira FA, Kerr-Pontes LR, Liesenfeld O, Feldmeier H. Selective mass treatment with ivermectin to control intestinal helminthiases and parasitic skin diseases in a severely affected population. Bull World Health Organ 2004, 82(8):563-571. 2622929, 15375445.
24. Burgess IF, Brown CM, Lee PN. Treatment of head louse infestation with 4% dimeticone lotion: randomised controlled equivalence trial. BMJ 2005, 330(7505):1423. 10.1136/bmj.38497.506481.8F, 558378, 15951310.
25. Kaul N, Palma KG, Silagy SS, Goodman JJ, Toole J. North American efficacy and safety of a novel pediculicide rinse, isopropyl myristate 50% (Resultz). J Cutan Med Surg 2007, 11(5):161-167.
26. Sonnberg S, Oliveira FA, de Melo IL, de Melo Soares MM, Becher H, Heukelbach J. Ovicidal efficacy of over-the-counter head lice products (German). 104. Jahrestagung der Deutschen Gesellschaft für Kinder- und Jugendmedizin 2008, Poster presentation. Munich (Germany).
27. Asenov A, Oliveira FA, Speare R, Liesenfeld O, Hengge UR, Heukelbach J. Efficacy of chemical and botanical over-the-counter pediculicides available in Brazil, and off-label treatments, against head lice ex vivo. Int J Dermatol 2009,
28. Nuttall GHF. The biology of Pediculus humanus. Parsitology 1917, 10:80-184.
29. Canyon D, Speare R. Do head lice spread in swimming pools?. Int J Dermatol 2007, 46(11):1211-1213. 10.1111/j.1365-4632.2007.03011.x, 17988347.
30. Meinking TL, Taplin D, Kalter DC, Eberle MW. Comparative efficacy of treatments for pediculosis capitis infestations. Arch Dermatol 1986, 122(3):267-271. 10.1001/archderm.122.3.267, 2420284.
31. Coleman CI, Gillespie EL, White CM. Probable topical permethrin-induced neck dystonia. Pharmacotherapy 2005, 25(3):448-450. 10.1592/phco.25.3.448.61596, 15843294.
32. Menegaux F, Baruchel A, Bertrand Y, Lescoeur B, Leverger G, Nelken B, Sommelet D, Hemon D, Clavel J. Household exposure to pesticides and risk of childhood acute leukaemia. Occup Environ Med 2006, 63(2):131-134. 10.1136/oem.2005.023036, 2078075,2078075, 16421392.