The effect of Eurycoma longifolia on sperm quality of male rats

Natural Product Communications

Volumn 4, Issue 10, 2009, Pages 1331-1336

  Chan, Kit Lam ^a   Low, Bin Seng ^a   Teh, Chin Hoe ^a   Das, Prashanta K ^b  

^a SCHOOL OF PHARMACEUTICAL SCIENCES   (Malaysia)

^b Lam Wah Ee Hospital   (Malaysia)

Author keywords

Eurycoma longifolia; Eurycomanone; Sperm quality; Standardized MeOH extract

Indexed keywords

13ALPHA(21)EPOXYEURYCOMANONE; 13ALPHA,21 DIHYDROEURYCOMANONE; ANDROGRAPHIS PANICULATA EXTRACT; EURYCOMA LONGIFOLIA EXTRACT; EURYCOMANOL; EURYCOMANONE; QUASSINOID DERIVATIVE; TESTOSTERONE; UNCLASSIFIED DRUG; PLANT EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL COUNT; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; EPIDIDYMIS; FRACTIONATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; LEYDIG CELL; LIQUID CHROMATOGRAPHY; MALE; MALE INFERTILITY; MASS SPECTROMETRY; MEDICINAL PLANT; NONHUMAN; PLANT ROOT; RAT; SEMEN ANALYSIS; SEMINIFEROUS TUBULE; SEXUAL FUNCTION; SPERMATOGENESIS; SPERMATOGONIUM; SPERMATOZOON ABNORMALITY; SPERMATOZOON COUNT; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; SPRAGUE DAWLEY RAT; TESTIS; TESTIS WEIGHT; TESTOSTERONE BLOOD LEVEL; TISSUE HOMOGENATE; ULTRAVIOLET SPECTROSCOPY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; EURYCOMA; SPERMATOZOON;

ANDROGRAPHIS PANICULATA; ANIMALIA; EURYCOMA LONGIFOLIA; RATTUS;

ANIMALS; EURYCOMA; MALE; MOLECULAR STRUCTURE; PLANT EXTRACTS; PLANT ROOTS; QUASSINS; RATS; SPERMATOZOA; TESTIS; TESTOSTERONE;

EID: 73449104306     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x0900401004     Document Type: Article

References (28)

1. WHO. (2003) Progress in Reproduction Health Research. World Health Organization, Geneva.
2. Royle JA, Walsh M. (1992) Watson's Medical-Surgical Nursing and Related Physiology. Baillière Tindall, London, 790.
3. Winston, RML. (1986) Infertility a sympathetic approach. P G Publishing Pte. Ltd, Singapore, 134.
4. Sharpe RM, Franks S. (2002) Environmental, lifestyle and infertility - an inter-generational issue. Nature Medicine, 8(S1), S33-S40.
5. Katz P, Nachtigall R, Showstack J. (2002) The economic impact of the assisted reproductive technologies. Nature Medicine, 8(S1), S29-S32. (Pubitemid 35175931)
6. Adimoelja A. (2000) Phytochemicals and the breakthrough of traditional herbs in the management of sexual dysfunctions. International Journal of Andrology, 23 (Suppl. 2), 82-84.
7. Chan KL, Choo CY, Morita H, Itokawa H. (1998) High performance liquid chromatography in phytochemical analysis of Eurycoma longifolia. Planta Medica, 64, 741-745.
8. Burkill IH. (1966) A dictionary of the economic products of the Malay Peninsula vol. 2, Government of Malaysia and Singapore, Kuala Lumpur, 1000-1001.
9. Chan KL, O'Neill MJ, Phillipson JD, Warhurst DC. (1986) Plants as sources of antimalarial drugs. Part 3. Eurycoma longifolia. Planta Medica, 52, 105-107.
10. Chan KL, Lee SP, Yuen KH. (1995) Antipyretic activity of quassinoids from Eurycoma longifolia Jack. In Chemical Prospecting in Malayan Forest, Ghazally I, Murtedza M, Laily D. (Eds). Pelanduk Publications, Selangor, 219-224.
11. Morita H, Kishi E, Takeya K, Itokawa H, Tanaka O. (1990) New quassinoids from the roots of Eurycoma longifolia. Chemistry Letters, 19, 749-752.
12. Kuo PC, Damu AG, Lee KH, Wu TS. (2004) Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia. Bioorganic Medicinal Chemistry, 12, 537-544.
13. Noor MM, Mohd Nor AHS, Hassan LC. (2004) The effect of Eurycoma longifolia Jack (Tongkat Ali) on sexual behaviour and sperm quality in rats. Malaysia Journal of Pharmaceutical Sciences, 2, 53-60.
14. Ang HH, Sim MK. (1998) Eurycoma longifolia Jack and orientation activities in sexually experienced male rats. Biological Pharmaceutical Bulletin, 21, 153-155. (Pubitemid 28120145)
15. Akbarsha MA, Murugaian P. (2000) Aspects of the male reproductive toxicity/ male antifertility property of andrographolide in albino rats: Effect on the testis and the cauda epididymal spermatozoa. Phytotherapy Research, 14, 432-435.
16. Low, BS, Chan, KL. Comparative bioavailability studies of the bioactive quassinoids of Eurycoma longifolia Jack. (Unpublished results).
17. Low B-S, Ng B-H, Choy W-P, Yuen K-H, Chan K-L. (2005) Bioavailability and pharmacokinetic studies of eurycomanone from Eurycoma longfolia. Planta Medica, 71, 803-807.
18. Clermont V. (1972) Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonial renewal. Physiological Review, 52, 198-236
19. Yakubu MT, Afolayan AJ. (2008) Effect of aqueous extract of Bulbine natalensis Baker stem on the sexual behaviour of male rats. International Journal of Andrology DOI 10.111/j.1365-2605.2008.00910.x
20. Rommerts FFG. (1992) Cell surface actions of steroids: a complimentary mechanism for regulation of spermatogenesis? In Spermatogenesis-Fertilization- Contraception. Nieschlag E, Habenicht U-F. (Eds). Springer Verlag, Berlin, 1-19.
21. Low BS. (2005) Fertility, Toxicology and Pharmacokinetic Studies of Eurycoma longifolia Jack in male rats. M. Sc. Thesis, Universiti Sains Malaysia, Penang, Malaysia.
22. Odell WD, Moyer DL. (1971) Physiology of Reproduction. C.V. Mosby Company, St. Louis, 123.
23. Chan KL, Choo CY, Abdullah NR, Ismail Z. (2004) Antiplasmodial studies of Eurycoma longifolia Jack using the lactate dehydrogenase assay of Plasmodium falciparum. Journal of Ethnopharmacology, 92, 223-237.
24. Remie R. (2000) Experimental surgery. In The Laboratory Rat, Krinke, GJ. (Ed). Academic Press: UK, 564.
25. Ewing LL, Wing T-Y, Cochran RC, Kromann N, Zirkin BR. (1983) Effect of luteinizing hormone on Leydig cell structure and testosterone secretion. Endocrinology, 112, 1763-1769. (Pubitemid 13049337)
26. WHO, World Health Organization. (1999) WHO Laboratory Manual for the examination of human semen and sperm-cervical mucus interaction. Cambridge University Press, UK, 4-20, 66.
27. Blackburn GF, Shah HP, Kenten JH, Leland J, Kamin RA, Link J, Peterman J, Powell MJ, Shah A, Talley SK, Wilkins E, Wu T-G, Massey RJ. (1991) Electrochemiluminescence detection for development of immunoassays and DNA probe assays for clinical diagnostics. Clinical Chemistry, 37, 1534-1539.
28. Elecsys® Testosterone Product Info, for Modulator Analytics E170, Elecsys® 1010 and 2010. (2001) Testosterone Product Code: 11776061, from Roche Diagnostics, Mannheim, Germany.