Activators of P-glycoprotein: Structure-activity relationships and investigation of their mode of action

ChemMedChem

Volumn 4, Issue 11, 2009, Pages 1897-1911

  Sterz, Katja ^a   Möllmann, Lars ^a   Jacobs, Anna ^a   Baumert, Dieter ^a   Wiese, Michael ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Activators; Cooperative effects; Heterocycles; MDR transporters; P glycoprotein

Indexed keywords

2 (2 METHOXYPHENYL) 9 METHYL 9H IMIDAZO[1,2 A]BENZIMIDAZOLE; 2 (3 AMINOPHENYL) 9 METHYL 9H IMIDAZO[1,2 A]BENZIMIDAZOLE; 2 (3 METHOXYPHENYL) 9 METHYL 9H IMIDAZO[1,2 A]BENZIMIDAZOLE; 2 (3 METHYLPHENYL) 9 METHYL 9H IMIDAZO[1,2 A]BENZIMIDAZOLE; 2 (4 AMINOPHENYL) 9 METHYL 9H IMIDAZO[1,2 A]BENZIMIDAZOLE; 2 (4 CHLOROPHENYL) 9 METHYL 9H IMIDAZO[1,2 A]BENZIMIDAZOLE; 2 (4 METHOXYPHENYL) 9 METHYL 9H IMIDAZO[1,2 A]BENZIMIDAZOLE; 2 (4 METHYLPHENYL) 5,6,7,8 TETRAHYDROIMIDAZO[2,1 B]BENZOTHIAZOLE; 2 (4 METHYLPHENYL) 9 METHYL 9H IMIDAZO[1,2 A]BENZIMIDAZOLE; 2 (4 NITROPHENYL) 5,6,7,8 TETRAHYDROIMIDAZO[2,1 B]BENZOTHIAZOLE; 4 (5,6,7,8 TETRAHYDROIMIDAZO[1,2 B]BENZOTHIAZ 2 YL)BENZONITRILE; 4 (9 BENZYL 9H IMIDAZO[1,2 A]BENZIMIDAZ 2 YL)BENZONITRILE; 4 (9 METHYL 9H IMIDAZO[1,2 A]BENZIMIDAZ 2 YL)BENZONITRILE; 4 [9 (2 METHYLALLYL) 9H IMIDAZO[1,2 A]BENZIMIDAZ 2 YL]BENZONITRILE; 4 [9 (3,4 DICHLOROBENZYL) 9H IMIDAZO[1,2 A]BENZIMIDAZ 2 YL]BENZONITRILE; 4 [9 (3,4 DIFLUOROBENZYL) 9H IMIDAZO[1,2 A]BENZIMIDAZ 2 YL]BENZONITRILE; 4 [9 (4 METHOXYBENZYL) 9H IMIDAZO[1,2 A]BENZIMIDAZ 2 YL]BENZONITRILE; 4 [9 [(6 CHLORO 4H BENZO[1,3]DIOXIN 8 YL)METHYL] 9H IMIDAZO[1,2 A]BENZIMIDAZ 2 YL]BENZONITRILE; 9 BENZYL 2 (4 METHOXYPHENYL) 9H IMIDAZO[1,2 A]BENZIMIDAZOLE; 9 BENZYL 2 (4 METHYLPHENYL) 9H IMIDAZO[1,2 A]BENZIMIDAZOLE; 9 BENZYL 2 (4 NITROPHENYL) 9H IMIDAZO[1,2 A]BENZIMIDAZOLE; 9 METHYL 2 NAPHTH 2 YL 9H IMIDAZO[1,2 A]BENZIMIDAZOLE; 9 METHYL 2 PHENYL 9H IMIDAZO[1,2 A]BENZIMIDAZOLE; BENZIMIDAZOLE DERIVATIVE; BENZOTHIAZOLE DERIVATIVE; COLCHICINE; DAUNORUBICIN; GLYCOPROTEIN P; RHODAMINE 123; UNCLASSIFIED DRUG; VINBLASTINE;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

BENZIMIDAZOLES; BENZOTHIAZOLES; CELL LINE, TUMOR; DAUNORUBICIN; DRUG RESISTANCE, NEOPLASM; HUMANS; IMIDAZOLES; P-GLYCOPROTEIN; RHODAMINE 123; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 73449099635     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200900283     Document Type: Article

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