Antisecretory and antiulcerogenic activities of the stem bark extract of Melaleuca bracteata and isolation of principles

Journal of Medicinal Plants Research

Volumn 3, Issue 10, 2009, Pages 822-824

  Adesanwo, J K ^a   Shode, F O ^b   Aiyelaagbe, O O ^c   Rabiu, O O ^c   Oyede, R T ^b   Oluwole, F S ^c  

^a OBAFEMI AWOLOWO UNIVERSITY   (Nigeria)

^b UNIVERSITY OF KWAZULU NATAL   (South Africa)

^c UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

Betulinic and Oleanolic acids; Gastroprotection; Melaleuca bracteata; Myrtaceae

Indexed keywords

ANTIULCER AGENT; BETULIC ACID; MELALEUCA BRACTEATA EXTRACT; MISOPROSTOL; OLEANOLIC ACID; PLANT EXTRACT; STOMACH SECRETION INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTISECRETORY ACTIVITY; ANTIULCEROGENIC ACTIVITY; ARTICLE; BARK; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; MALE; MELALEUCA; MELALEUCA BRACTEATA; NONHUMAN; RAT; SCORING SYSTEM; STOMACH ACID SECRETION; STOMACH PROTECTION; STOMACH ULCER;

ANIMALIA; MELALEUCA BRACTEATA; MYRTACEAE; RATTUS;

EID: 73449097446     PISSN: 19960875     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Aboutabl EA, El Tohamy SF, De Footer HL, De Buyck LF (1990). A comparative study of the essential oils from three Melaleuca Species growing in Egypt. Flavour Fragrance J. 6(2): 139-141.
2. Adesanwo JK, Ekundayo O, Oluwole FS, Olajide OA, Van Den Berge AJJ, Findlay JA (2003). The effect of T. potatoria and its constituent betulinic acid on gastric acid secretion and experimentally-induced gastric ulceration. Niger. J. Physiol. Sci. 18(1-2): 21-26.
3. Elegbe ER (1978). A cooperative studies on starvation indomethacin induced ulceration in rat. Biochem. Exp. Biol. 16: 159-166.
4. Ghosh MN, Schild HO (1958). Continuous recording of Gastric acid secretion in rat. Brit. J. Pharmacol. 21: 31- 1396.
5. Han SK, Ko YI, Park SJ, Jin YS, Kirn YM (1997). Oleanolic acid and ursolic acid stabilize liposomal membrances. Lipids 32: 769-773.
6. Honda T, Rounds BV, Bore L, Finlay HJ, Favaloro FG, Sun N, Wang Y, Sporn MB, Gribble GW (2000). Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages. J. Med. Chem. 43: 4233-4246.
7. Hutchings A, Scott AH, Lewis G, Cunningham A (1996). Zulu Medicinal Plants: An Inventory, University of Natal Press, Pietermaritzburg, South Africa p. 312.
8. Kashiwada Y, Nagao T, Hashimoto A, Ikeshiro Y, Okabe H, Cosentino LM, Lee KH (2000). Anti-AIDS agents 38. Anti-HIV. Activity of 3-0-acyi ursolic acid derivatives. J. Nat. Prod. 63:1619-1622.
9. Luis A, Guillermo SH, Jaime AR (2002). Gastroprotective activity of Oleanolic acid and derivatives on experimentally induced gastric lessions in rats and mice. J. Pharm. Pharmacol. 54(4): 583.
10. Naidu BP (2003). Production of betaine from Australian Melaleuca Species for use in Agriculture to reduce plant stress. Aust. J. Exp. Agric. 43(9): 1163-1170.
11. Penfold AR, Morrison FR (2002). Essential oils of the plant family Mytacea "Tea Tree Oils". In Tea Tree Oils of Oceania Region. Edited by Ivor Hughes. Herbdata New Zealand. http:/www.herbdatanz.com/tea-tree-oils.htm.
12. Shibata S (2001). Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds. J. Korean Med. Sci. SuppI. S28-37 3.
13. Somova LO, Nadar A, Rammanan P, Shode FO (2003). Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension. Phytomedicine 10: 115-121.
14. 13C NMR resonantes of oleanolic acid and 18α-oleanolic acid, ursolic acid and their 11-oxo derivatives. Magn. Reson. Chem. 41: 636-638.
15. Wilkinson JM, Cavanagh HMA (2005). Antibacterial activity of essential oils from Australian native plants. Phytother. Res. 19 (7): 643-646.
16. Yoshikawa M, Matsuda H (2000). Antidiabetogenic activity of oleanolic acid glycosides from medicinal foodstuffs. Biofactors 13: 231-237.
17. Zhang Z, Chang Q, Zhu M, Huang Y, Ho WK, Chen Z (2001). Characterization of antioxidants present in hawthorn fruits. J. Nutr. Biochem. 12: 144-152.