Optimization of a Direct Analysis in Real Time/Time-of-Flight Mass Spectrometry Method for Rapid Serum Metabolomic Fingerprinting

Journal of the American Society for Mass Spectrometry

Volumn 21, Issue 1, 2010, Pages 68-75

  Zhou, Manshui ^a   McDonald, John F ^a,b   Fernández, Facundo M ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b Ovarian Cancer Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DERIVATIZATIONS; DIRECT ANALYSIS; DIRECT ANALYSIS IN REAL TIME; DISEASE DIAGNOSIS; FLIGHT MASS SPECTROMETRY; GAS TEMPERATURE; HEALTHY HUMANS; HIGH-THROUGHPUT; HUMAN SERUM; INSTRUMENTAL PARAMETERS; ION SIGNALS; MASS SPECTRA; MEMORY EFFECTS; METABOLIC DISORDERS; METABOLOMICS; POTENTIAL TOOL; QUADRUPOLES; SERUM SAMPLES; SPECTRAL FEATURE; TIME OF FLIGHT MASS SPECTROMETRY; TIME-DEPENDENT; UNDERLYING CAUSE;

BODY FLUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLISM; METABOLITES; SIGNAL TO NOISE RATIO;

DIAGNOSIS;

HELIUM; PLASMA PROTEIN;

ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CONTROLLED STUDY; DERIVATIZATION; FLOW RATE; HUMAN; METABOLOMICS; PRECIPITATION; PROCESS OPTIMIZATION; QUADRUPOLE MASS SPECTROMETRY; REPRODUCIBILITY; SIGNAL NOISE RATIO; SIGNAL PROCESSING; TEMPERATURE; TIME; TIME OF FLIGHT MASS SPECTROMETRY;

BLOOD PROTEINS; HUMANS; MASS SPECTROMETRY; METABOLOMICS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SERUM; TEMPERATURE; TIME FACTORS;

EID: 73449084060     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2009.09.004     Document Type: Article

References (24)

1. Dettmer K., Aronov P.A., and Hammock B.D. Mass Spectrometry-Based Metabolomics. Mass Spectrom. Rev 26 (2007) 51-78
2. Ala-Korpela M. Critical Evaluation of 1H NMR Metabonomics of Serum as a Methodology for Disease Risk Assessment and Diagnostics. Clin. Chem. Lab. Med 46 (2008) 27-42
3. Chan E.C.Y., Koh P.K., Mal M., Cheah P.Y., Eu K.W., Backshall A., Cavill R., Nicholson J.K., and Keun H.C. Metabolic Profiling of Human Colorectal Cancer Using High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance (HR-MAS NMR) Spectroscopy and Gas Chromatography Mass Spectrometry (GC/MS). J. Proteome Res 8 (2009) 352-361
4. 1H NMR metabonomics of serum. MAGMA 19 (2006) 281-296
5. Denkert C., Budczies J., Kind T., Weichert W., Tablack P., Sehouli J., Niesporek S., Könsgen D., Dietel M., and Fiehn O. Mass Spectrometry-Based Metabolic Profiling Reveals Different Metabolite Patterns in Invasive Ovarian Carcinomas and Ovarian Borderline Tumors. Cancer Res 66 (2006) 10795-10804
6. Fancy S.A., Beckonert O., Darbon G., Yabsley W., Walley R., Baker D., Perkins G.L., Pullen F.S., and Rumpel K. Gas Chromatography/Flame Ionization Detection Mass Spectrometry for the Detection of Endogenous Urine Metabolites for Metabonomic Studies and Its Use as a Complementary Tool to Nuclear Magnetic Resonance Spectroscopy. Rapid Commun. Mass Spectrom 20 (2006) 2271-2280
7. Lu W., Bennett B.D., and Rabinowitz J.D. Analytical Strategies for LC-MS-Based Targeted Metabolomics. J. Chromatogr 871 (2008) 236-242
8. Michopoulos F., Lai L., Gika H., Theodoridis G., and Wilson I. UPLC-MS-Based Analysis of Human Plasma for Metabonomics Using Solvent Precipitation or Solid Phase Extraction. J. Proteome Res 8 (2009) 2114-2121
9. Pasikanti K.K., Ho P.C., and Chan E.C.Y. Gas Chromatography/Mass Spectrometry in Metabolic Profiling of Biological Fluids. J. Chromatogr 871 (2008) 202-211
10. Haapala M., Pol J., Saarela V., Arvola V., Kotiaho T., Ketola R.A., Franssila S., Kauppila T.J., and Kostiainen R. Desorption Atmospheric Pressure Photoionization. Anal. Chem 79 (2007) 7867-7872
11. Cody R.B., Larame J.A., and Durst H.D. Versatile New Ion Source for the Analysis of Materials in Open Air Under Ambient Conditions. Anal. Chem 77 (2005) 2297-2302
12. Andrade F.J., Shelley J.T., Wetzel W.C., Webb M.R., Gamez G., Ray S.J., and Hieftje G.M. Atmospheric Pressure Chemical Ionization Source. 2. Desorption-Ionization for the Direct Analysis of Solid Compounds. Anal. Chem 80 (2008) 2654-2663
13. Ratcliffe L.V., Rutten F.J., Barrett D.A., Whitmore T., Seymour D., Greenwood C., Aranda-Gonzalvo Y., Robinson S., and McCoustra M. Surface Analysis Under Ambient Conditions Using Plasma-Assisted Desorption/Ionization Mass Spectrometry. Anal. Chem 79 (2007) 6094-6101
14. Jackson A.T., Scrivens J.H., Williams J.P., Baker E.S., Gidden J., and Bowers M.T. Microstructural and Conformational Studies of Polyether Copolymers. Int. J. Mass Spectrom 238 (2004) 287-297
15. Harper J.D., Charipar N.A., Mulligan C.C., Zhang X., Cooks R.G., and Ouyang Z. Low-Temperature Plasma Probe for Ambient Desorption Ionization. Anal. Chem 80 (2008) 9097-9104
16. Na N., Zhang C., Zhao M., Zhang S., Yang C., Fang X., and Zhang X. Direct Detection of Explosives on Solid Surfaces by Mass Spectrometry with an Ambient Ion Source Based on Dielectric Barrier Discharge. J. Mass Spectrom 42 (2007) 1079-1085
17. Petucci C., Diffendal J., Kaufman D., Mekonnen B., Terefenko G., and Musselman B. Direct Analysis in Real Time for Reaction Monitoring in Drug Discovery. Anal. Chem 79 (2007) 5064-5070
18. Zhao Y., Lam M., Wu D., and Mak R. Quantification of Small Molecules in Plasma with Direct Analysis in Real Time Tandem Mass Spectrometry, Without Sample Preparation and Liquid Chromatographic Separation. Rapid Commun. Mass Spectrom 22 (2008) 3217-3224
19. Fernandez F.M., Cody R.B., Green M.D., Hampton C.Y., McGready R., Sengaloundeth S., White N.J., and Newton P.N. Characterization of Solid Counterfeit Drug Samples by Desorption Electrospray Ionization and Direct Analysis-in-Real-Time Coupled to Time-of-Flight Mass Spectrometry. Chem. Med. Chem 1 (2006) 702-705
20. Pierce C.Y., Barr J.R., Cody R.B., Massung R.F., Woolfitt A.R., Moura H., Thompson H.A., and Fernandez F.M. Ambient Generation of Fatty Acid Methyl Ester Ions from Bacterial Whole Cells by Direct Analysis in Real Time (DART) Mass Spectrometry. Chem. Commun 8 (2007) 807-809
21. Haefliger O.P., and Jeckelmann N. Direct Mass Spectrometric Analysis of Flavors and Fragrances in Real Applications Using DART. Rapid Commun. Mass Spectrom 21 (2007) 1361-1366
22. Schurek J., Vaclavik L., Hooijerink H.D., Lacina O., Poustka J., Sharman M., Caldow M., Nielen M.W.F., and Hajslova J. Control of Strobilurin Fungicides in Wheat Using Direct Analysis in Real Time Accurate Time-of-Flight and Desorption Electrospray Ionization Linear Ion Trap Mass Spectrometry. Anal. Chem 80 (2008) 9567-9575
23. Williams J.P., Patel V.J., Holland R., and Scrivens J.H. The Use of Recently Described Ionization Techniques for the Rapid Analysis of Some Common Drugs and Samples of Biological Origin. Rapid Commun. Mass Spectrom 20 (2006) 1447-1456
24. Harris G.A., and Fernandez F.M. Simulations and Experimental Investigation of Atmospheric Transport in an Ambient Metastable-Induced Chemical Ionization Source. Anal. Chem 81 (2009) 322-329