Can Burkholderia cepacia complex be eradicated with nebulised Amiloride and TOBI®?

Journal of Cystic Fibrosis

Volumn 9, Issue 1, 2010, Pages 73-74

  Ball, R ^a   Brownlee, K G ^a   Duff, A J A ^a   Denton, M ^a   Conway, S P ^a   Lee, T W R ^a  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; TOBRAMYCIN;

ADOLESCENT; BACTERIAL GROWTH; BURKHOLDERIA CEPACIA COMPLEX; BURKHOLDERIA CEPACIA INFECTION; CHILD; CLINICAL ARTICLE; CYSTIC FIBROSIS; DISEASE EXACERBATION; DRUG EFFICACY; DRUG TOLERABILITY; ERADICATION THERAPY; FEMALE; HUMAN; LETTER; LUNG INFECTION; MALE; NEBULIZATION; PATIENT COMPLIANCE; SCHOOL CHILD; TREATMENT DURATION;

ADOLESCENT; AMILORIDE; ANTI-BACTERIAL AGENTS; BURKHOLDERIA CEPACIA COMPLEX; BURKHOLDERIA INFECTIONS; CHILD; CYSTIC FIBROSIS; DRUG THERAPY, COMBINATION; HUMANS; NEBULIZERS AND VAPORIZERS; SODIUM CHANNEL BLOCKERS; TOBRAMYCIN;

EID: 73449084057     PISSN: 15691993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcf.2009.11.001     Document Type: Letter

References (5)

1. Mahenthiralingam E., Baldwin A., and Dowson C.G. Burkholderia cepacia complex bacteria: opportunistic pathogens with important natural biology. J Appl Microbiol 104 6 (Jun 2008) 1539-1551
2. Jones A.M., Dodd M.E., Govan J.R., et al. Burkholderia cenocepacia and Burkholderia multivorans: influence on survival in cystic fibrosis. Thorax 59 (2004) 948-951
3. Cohn R.C., Rudzienski L., and Putnam R.W. In vitro antimicrobial activity of amiloride analogs against Pseudomonas. Chemotherapy 38 (1992) 232-237
4. Treerat P., Widmar F., Middleton P.G., Iredell J., and George A.M. In vitro interactions of tobramycin with various nonantibiotics against Pseudomonas aeruginosa and Burkholderia cenocepacia. FEMS Microbiol Lett 285 (2008) 40-50
5. Middleton P.G., Kidd T.J., and Williams B. Combination aerosol therapy to treat Burkholderia cepacia complex. Eur Respir J 26 (2005) 305-308