Use of cerebrospinal fluid biomarkers for diagnosis of incipient Alzheimer disease in patients with mild cognitive impairment

Clinical Chemistry

Volumn 56, Issue 1, 2010, Pages 7-9

  Dean, Robert A ^a   Shaw, Leslie M ^b  

^a ELI LILLY AND COMPANY   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; FLUORODEOXYGLUCOSE;

ALZHEIMER DISEASE; AUTOPSY; BRAIN ATROPHY; CEREBROSPINAL FLUID; CLINICAL PRACTICE; DAILY LIFE ACTIVITY; DISEASE COURSE; DISEASE MARKER; ENZYME LINKED IMMUNOSORBENT ASSAY; FOLLOW UP; HUMAN; IMMUNOASSAY; LUMBAR PUNCTURE; MILD COGNITIVE IMPAIRMENT; NEUROFIBRILLARY TANGLE; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; POSTDURAL PUNCTURE HEADACHE; PREDICTION; SHORT SURVEY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; BIOLOGICAL MARKERS; COGNITION DISORDERS; HUMANS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; TAU PROTEINS;

EID: 73449083442     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2009.134692     Document Type: Short Survey

References (6)

1. Alzheimer's Association. 2009 Alzheimer's disease facts and figures. http://www.alz.org/alzheimers-disease-facts-figure.asp. (Accessed December 2009).
2. Shaw LM, Vanderstichele H, Knapik-Czajka M, Clark CM, Aisen PS, Petersen RC, et al. Cerebrospinal fluid biomarker signature in Alzheimer's Disease Neuroimaging Initiative subjects. Ann Neurol 2009;65:403-13.
3. Mattsson N, Zetterberg H, Hansson O, Andreasen N, Parnetti L, Jonsson M, et al. CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment. JAMA 2009;302:385-93.
4. Hardy J. The amyloid hypothesis for Alzheimer's disease: a critical reappraisal. J Neurochem 2009; 110:1129 -34.
5. Siemers E, DeMattos R, May PC, Dean RA. Role of biochemical Alzheimer's disease biomarkers as end points in clinical trials. Biomark Med. Forthcoming 2010.
6. Perrin RJ, Fagan A, Holtzman DM. Multimodal techniques for diagnosis and prognosis of Alzheimer's disease. Nature 2009;461:916 -22.