Maximum tolerated dose and repeated dose toxicity studies of triethylenetetramine dihydrochloride, a copper chelating agent, by oral administration to beagle dogs

Japanese Pharmacology and Therapeutics

Volumn 26, Issue 5, 1998, Pages 99-121

  Maemura, Shunichi ^a   Matsuzaki, Yutaka ^a   Asano, Takayuki ^a   Minematsu, Sumio ^a   Yanagisawa, Toshihiko ^a   Iijima, Osamu T ^a   Sasaki, Hiromi ^a   East, Philip W ^b   Creasy, Dianne M ^b   Virgo, David M ^b  

^a TSUMURA AND CO   (Japan)

^b Eye Res Ctr Huntingdon Life S   (United Kingdom)

Author keywords

Ataxia; Copper chelating agent; Dog; General toxicity; Triethylenetetramine dihychloride; Wilson's disease

Indexed keywords

CHELATING AGENT; TRIENTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATAXIA; CHRONIC TOXICITY; CONTROLLED STUDY; COPPER METABOLISM; DOG; FLUID INTAKE; HISTOPATHOLOGY; MAXIMUM PERMISSIBLE DOSE; NONHUMAN; ORAL DRUG ADMINISTRATION; TOXICITY TESTING; TOXICOKINETICS; WILSON DISEASE;

EID: 7344261274     PISSN: 03863603     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

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2. Walshe JM : Treatment of Wilson's disease with trientine (triethylene tetramine) dihydrochloride. Lancet i : 643-647, 1982
3. Walshe JM : Management of penicillamine nephropathy in Wilson's disease: A new chelating agent. Lancet ii : 1401-1402, 1969
4. Davis GK, Mertz W: Copper. Mertz W ed, Trace elements in human and animal nutrition. Vol.1, p. 301-364, Academic Press, New York, 1987
5. Takeda T et al : D-Penicillamine toxicity in mice pathological findings. Toxicol Appl Pharmacol 55 : 324-333, 1980
6. Zentek J et al : Investigations on copper deficiency in growing dogs (in German). J Vet Med A 38 : 561-570, 1991
7. Yanagisawa T et al : Subacute and chronic toxicity studies of triethylenetetramine dihydrochloride (TJA-250) by oral administration to F344 rats. J Toxicol Sci (submitted)