Acinar cell carcinoma of the pancreas associated with hypoglycemia: Involvement of 'big' insulin-like growth factor-II

Journal of Gastroenterology

Volumn 33, Issue 5, 1998, Pages 761-765

  Mizuta, Yohei ^a   Isomoto, Hajime ^a   Futuki, Yoji ^a   Ehara, Naomi ^a   Takeshima, Fuminao ^a   Omagari, Katsuhisa ^a   Murase, Kunihiko ^a   Yakata, Yuichi ^b   Senjyu, Masahiro ^b   Masuda, Jyun Ichi ^c   Ikuno, Nobuhiro ^c   Haraguchi, Masuho ^c   Iwasaki, Keisuke ^c   Shimokawa, Isao ^a   Kohno, Shigeru ^a  

^a NAGASAKI UNIVERSITY   (Japan)

^b Sasebo General Hospital   (Japan)

^c Sasebo Shiritsu Sogo Hospital   (Japan)

Author keywords

Acinar cell carcinoma; Carcinoma of the pancreas; Hypoglycemia; Insulin like growth factor II

Indexed keywords

GLUCAGON; GLUCOSE; INSULIN; SOMATOMEDIN B;

ACINAR CELL CARCINOMA; AGED; ARTICLE; AUTOPSY; CACHEXIA; CASE REPORT; CAUSE OF DEATH; COMPUTER ASSISTED TOMOGRAPHY; GLUCAGON BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPOGLYCEMIA; IMMUNOBLOTTING; INSULIN BLOOD LEVEL; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PANCREAS CARCINOMA; PRIORITY JOURNAL;

AGED; CARCINOMA, ACINAR CELL; DIAGNOSIS, DIFFERENTIAL; HUMANS; HYPOGLYCEMIA; INSULIN-LIKE GROWTH FACTOR II; MALE; PANCREATIC NEOPLASMS;

EID: 7344243777     PISSN: 09441174     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005350050170     Document Type: Article

References (19)

1. Daughaday WH, Trivedi B, Kapasia M. Measurement of insulin-like growth factor II by a specific radioreceptor assay in serum of normal individuals, patients with abnormal growth hormone secretion, and patients with tumor associated hypoglycemia. J Clin Endocrinol Metab 1981;53:289-294.
2. Daughaday WH, Emanuele MA, Brooks MH, et al. Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia. N Engl J Med 1988;319:1434-1440.
3. Sturrock NDC, Selby C, Hosking DJ. Spontaneous hypoglycaemia in a non-insulin-dependent diabetes mellitus patient with disseminated pancreatic carcinoma. Diabet Med 1997;14:324-326.
4. Fukuda I, Hizuka N, Takano K, et al. Characterization of insulin-like growth factor II (IGF-II) and IGF binding proteins in patients with non-islet-cell tumor hypoglycemia. Endocrine J 1993;40:111-119.
5. Daughaday WH. Autocrine, paracrine and endocrine manifestations of insulin-like growth factor secretion by tumors. In: Spencer EM (ed) Modern concepts of insulin-like growth factors. New York: Elsevier, 1991;557.
6. Daughaday WH, Kapadia M. Significance of abnormal serum binding of insulin like growth factor II in the development of hypoglycemia in patients with non-islet-cell tumors. Proc Natl Acad Sci USA 1986;86:6778-6782.
7. Shapiro ET, Bell GI, Polonsky KS, et al. Tumor hypoglycemia: Relationship to high molecular weight insulin-like growth factor II. J Clin Invest 1990;85:1672-1679.
8. Fukuda I, Hizuka N, Takano K, et al. Circulating forms of insulin-like growth factor II (IGF-II) in patients with non-islet cell tumor hypoglycemia. Endocrinol Metab 1994;1:89-95.
9. Zapf J, Futo E, Peter M, et al. Can big insulin-like growth factor II in serum of tumor patients account for the development of extrapancreatic tumor hypoglycemia? J Clin Invest 1992;90:2574-2584.
10. Wasada T, Hizuka N, Yamamoto M, et al. An insulin-like growth factor II-producing histiocytoma associated with hypoglycemia: Analysis of the peptide, its gene expression, and glucose-transporter isoforms. Metabolism 1992;41:310-316.
11. Cubilla AC, Fitzgerald PJ. Tumors of the exocrine pancreas, Washington DC: Armed Forces Institute of Pathology. 1984;208-212.
12. Burns WA, Matthews MJ, Hamosh M, et al. Lipase-secreting acinar cell carcinoma of the pancreas with polyarthropathy. Cancer 1974;33:1002-1009.
13. Radin DR, Colletti PM, Forrester DM, et al. Pancreatic acinar cell carcinoma with subcutaneous and intraosseous fat necrosis. Radiology 1986;158:67-68.
14. Horiuchi T, Shinohara Y, Sakamoto Y, et al. Expression of insulin-like growth factor II by a gastric carcinoma associated with hypoglycaemia. Virchows Arch 1994;424:449-452.
15. Merimee TJ. Insulin-like growth factors in patients with nonislet cell tumors and hypoglycemia. Metabolism 1986;35:360-363.
16. Baxter RC, Daughaday WH. Impaired formation of the ternary insulin-like growth factor-binding protein complex in patients with hypoglycemia due to nonislet cell tumors. J Clin Endocrinol Metab 1991;73:696-702.
17. Eastman RC, Carson RE, Orloff DG, et al. Glucose utilization in a patient with hepatoma and hypoglycemia: Assessment by positron emission tomography. J Clin Invest 1992;89:1958-1963.
18. Zapf J. Role of insulin-like growth factor (IGF) II and IGF binding proteins in extrapancreatic tumour hypoglycemia. J Intern Med 1993;234:543-552.
19. Hunter SJ, Daughaday WH, Callender ME, et al. A case of hepatoma associated with hypoglycemia and overproduction of IGF-II (E-21): Beneficial effects of treatment with growth hormone and intrahepatic adriamycin. Clin Endocrinol 1994;41: 397-401.