Abnormal central serotonergic activities in spontaneously hypertensive rats (SHR)

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 20, Issue 6, 1998, Pages 473-478

  Kim, Sung Jin ^a   Ko, Kwang Ho ^b  

^a Kyung Hee University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

5 HIAA; Hypertension; Probenecid; Serotonergic nervous system; Serotonin; Spontaneously hypertensive rats (SHR)

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; PROBENECID; SEROTONIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DRUG ACTIVITY; HYPERTENSION; MALE; NEUROPATHOLOGY; NONHUMAN; PATHOPHYSIOLOGY; RAT; SEROTONIN RELEASE; SEROTONINERGIC SYSTEM; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALS; BRAIN; CEREBELLUM; DIENCEPHALON; HYPERTENSION; MALE; PROBENECID; RATS; RATS, INBRED SHR; RATS, INBRED WKY; SEROTONIN; TELENCEPHALON;

EID: 7344233082     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.1998.20.6.485710     Document Type: Article

References (19)

1. Black, H.R. Blood pressure control. Am J Mod 1996, 101: 4A50S-4A55S.
2. Lambert, G.W., Ferrier, C., Kaye, D.M. et al. Monoaminergic neuronal activity in subcortical brain regions in essential hypertension. Blood Press 1994, 3: 55-66.
3. Lambert, G.W., Vaz, K., Rajkumar, C. et al. Cerebral metabolism and its relationship with sympathetic nervous activity in essential hypertension: Evaluation of the Dickinsion hypothesis. J Hypertens 1996, 14: 951-9.
4. Mathias, C.J. Role of the central nervous system in human secondary hypertension. J Cardiovasc Pharmacol 1987, 10: S93-9.
5. van Helden, D.F., Woolridge, S. Role of nerves in hypertension. Nature 1990, 348: 118-9.
6. Neff, N.H., Lin, R.C., Ngai, S.K., Costa, E. Turnover rate measurements of brain serotonin in unanesthetized rats. Adv Biochem Psychopharmacol 1969, 1: 91-109.
7. Miller, T.B., Ross, C.R. Transport of organic cations and anions by choroid plexus. J Pharmacol Exp Ther 1976, 196: 771-7.
8. Miller, F.P., Cox, R.H. Jr., Snodgrass, W.R., Maickel, R.P. Comparative effects of O-chloramphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid. Biochem Pharmacol 1970, 9: 435-42.
9. Pfeffer, J.M., Pfeffer, M.A., Frohlich, E.D. Validity of an indirect tail-cuff method for determining systolic arterial pressure in unanesthetized normotensive and spontaneously hypertensive rats. J Lab Clin Med 1971, 78: 957-62.
10. Jobe, J.C., Ko, K.H., Dailey, J.W. Abnormalities in norepinephrine turnover rate in the central nervous system of the genetically epilepsy-prone rat. Brain Res 1984, 290: 357-60.
11. Reid, J.L. Hypertension and the brain. Br Med Bull 1994, 50: 371-80.
12. Kuhn, D.M. Review of the role of the central serotonergic neuronal system in Mood pressure regulation. Hypertension 1980, 2: 243-55.
13. Koulu, M., Saavedra, J.K., Bjelogric, N., Niwa, M., Agren, K., Linnolia, M. Serotonin turnover in discrete hypothalamic nuclei and mesencephalic raphe nuclei of young and adult spontaneously hypertensive rats. Brain Res 1986, 379: 257-63.
14. McCall, R.B., Patel, B.N., Harris, L.T. Effects of serotonin 1 and serotonin 2 receptor agonists and antagonists on Blood pressure, heart rate and sympathetic nerve activity. J Pharmacol Exp Ther 1987, 242: 1152-9.
15. Kubo, T., Ito, T., Shibanoki, S., Kogure, M., Ishikawa, K. Role of central serotonergic systems in the development of hypertension in spontaneously hypertensive rats. Brain Res 1990, 516: 151-4.
16. Lambert, G.W., Kaye, D.M., Cox, H.S. et al. Regional 5-hydroxyindoleacetic acid production in humans. Life Sci 1995, 57: 255-67.
17. Breuer, J., Georgaraki, A., Sieverding, L., Baden, W., Apitz, J. Increased turnover of serotonin in children with pulmonary hypertension secondary to congenital heart disease. Pediatr Cardiol 1996, 17: 214-9.
18. Cooper, J.R., Bloom, F.E., Roth R.H. Serotonin and histamine. In: The Biochemical Basis of Neuropharmacology. Oxford University Press: New York 1986, 315-51.
19. Steinbusch, H.W.M. Serotonin-immunoreactive neurons and their projections in the CNS. In: Handbook of Chemical Neuroanatomy, Volume 3, Part II: Classical Transmitters and Transmitter Receptors in the CNS. A. Bjorklund, T. Hokfelt, M.J. Kuhar (Eds.). Elsevier Amsterdam 1984, 68-125.