Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma;Zusatzliche Gabe von Theophyllin bei einer Therapie mit inhalativen Steroiden im Vergleich zu einer Verdoppelung der Dosis inhalativer Steroide bei Asthma

Pneumologie

Volumn 52, Issue 7, 1998, Pages 377-384

  Ukena, D ^a   Harnest, U ^b   Sakalauskas, R ^b   Magyar, P ^c   Vetter, N ^d   Steffen, H ^b   Leichtl, S ^e   Rathgeb, F ^e   Keller, A ^e   Steinijans, V W ^e  

^a SAARLAND UNIVERSITY   (Germany)

^b Semmelweis University of Medicine ^*

^c SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^d Pulmologisches Zentrum   (Austria)

^e ALTANA PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BECLOMETASONE DIPROPIONATE; SALBUTAMOL; THEOPHYLLINE; BECLOMETASONE;

ARTICLE; ASTHMA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG USE; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN TISSUE; INHALATIONAL DRUG ADMINISTRATION; LUNG FUNCTION; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; THEOPHYLLINE BLOOD LEVEL; ADOLESCENT; ADULT; AGED; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG COMBINATION; DRUG EFFECT; EUROPE; MIDDLE AGED;

ADOLESCENT; ADULT; AGED; ASTHMA; BECLOMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; EUROPE; FORCED EXPIRATORY VOLUME; HUMANS; MIDDLE AGED; THEOPHYLLINE;

EID: 7344227276     PISSN: 09348387     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. American Thoracic Society report on chronic bronchitis, asthma, and pulmonary emphysema. Am. Rev. Respir. Dis. 136 (1987) 224 -225
2. Banner K. H, C. P. Page: Theophylline and selective phosphodiesterase inhibitors as anti-inflammatory drugs in the treatment of bronchial asthma. Eur. Respir. J. 8 (1995) 996-1000
3. Barnes, P. J.: Inhaled glucocorticoids for asthma. N. Engl. J. Med. 332 (1995) 868-875
4. Barnes, P. J, I. Adcock: Anti-inflammatory actions of steroids: molecular mechanisms. Trends Pharmacol. Sci. 14 (1993) 436-441
5. Barnes, P. J., B. Jonsson, J. B. Klim: The cost of asthma. Eur. Respir. J. 9 (1996) 636-642
6. Barnes, P. J., R. A. Pauwels: Theophylline in the management of asthma: time for reappraisal? Eur. Respir. J. 7 (1994) 579-591
7. Barnes, P. J., S. Pedersen: Efficacy and safety of inhaled corticosteroids in asthma. Am. Rev. Respir. Dis. 148 (1993) S1-S26
8. ® in moderate to severe asthma. J. Allergy Clin. Immunol. 93 (Suppl) (1994) 186
9. Dahl, R., B. Lundbaek, J. M. Malo et al.: A dose-ranging study of fluticasone propionate in adult patients with moderate asthma. Chest 104 (1993) 352-358
10. Elashoff, J. D.: NQUERY Advisor User's Guide. Dixon Associates, Los Angeles, CA 1995
11. European Agency for the Evaluation of Medicinal Products. Human Medicines Evaluation Unit. Note for Guidance on Statistical Principles for Clinical Trials (CPMP/ICH/363/96). ICH Topic E9, Statistical Principles for Clinical Trials, Step 3. January 17, 1997
12. Evans, D. J., D. A. Taylor, A. Keller et al.: Low dose inhaled steroid plus theophylline vs. high dose inhaled steroid in the control of asthma. Am. J. Respir. Crit. Care Med. 155 (1997) A202
13. Geddes, D. M.: Inhaled corticosteroids: benefits and risks. Thorax 47 (1992) 404-407
14. Greening, A. P., P. W. Ind, M. Northfield, G. Shaw: Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid: Lancet 344 (1994) 219-224
15. Holm, S.: A simple sequentially rejective multiple test procedure. Scand. J. Statist. 6 (1979) 65-70
16. International Consensus Report on Diagnosis and Management of Asthma. National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, March 1992. Publication No. 92-3091
17. Kidney, J., M. Dominguez, P. M. Taylor, M. Rose, K. F. Chung, P. J. Barnes: Immunomodulation by theophylline in asthma: demonstration by withdrawal of therapy. Am. J. Respir. Crit. Care Med. 151 (1995) 1907-1914
18. Nassif, B. G., M. Weinberger, R. Thompson, W. Huntley: The value of theophylline in steroid-dependent asthma. N. Engl. J. Med. 304 (1981) 71-75
19. Pedersen, S., P. O'Byrne: A comparison of the efficacy and safety of inhaled corticosteroids in asthma. Allergy S2 (1997) (Suppl 39) 134
20. Prowse, K., E. H. Walters: Can theophylline reduce the need for oral corticosteroids? J. Int. Med. Research 7 (1979) 101-105
21. Rabe, K. F., H. Magnussen, G. Dent: Theophylline and selective PDB inhibitors as bronchodilators and smooth muscle relaxants. Eur. Respir. J. 8 (1995) 637-642
22. ®, salbutamol, and their combination in asthmatic patients on high-dose inhaled steroids. Am. J. Respir. Crit. Care Med. 151 (1995) 325-332
23. Ryan, G., K. M. Latimer, J. Dolovich, F. E. Hargreave: Bronchial responsiveness to histamine relationship to diurnal variation of peak flow rate. Improvement after bronchodilator, and airway calibre. Thorax 37 (1982) 423-429
24. Steinijans, V. W.: Statistical evaluation of comparative clinical trials: what are the methods of choice. Henry-Stewart Conference on "Understanding Equivalence Testing for Inhaled Drugs", London, June 20, 1997. (Conference report in preparation.)
25. Steinijans, V. W., R. Sauter, A. Böhm, H. Staudinger: Pharmacokinetic profile of a new sustained-release theophylline pellet formulation for once-daily evening administration. Drug Research 38 (1988) 1241-1250
26. Sullivan, P. J., S. Bekir, Z. Jaffar, C. Page, P. Jeffery, J. Costello: Antiinflammatory effects of low-dose theophylline in atopic asthma. Lancet 343 (1994) 1006-1008
27. Woolcock, A., B. Lundbaek, N. Ringdahl, L. A. Jacques: Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids. Am. J. Respir. Crit. Care Med. 153 (1996) 1481-1488