An embarrassment of riches: The stochastic generation of beneficial mutations

Genetica

Volumn 102-103, Issue , 1998, Pages 145-155

  Gessler, Damian D G ^a   Xu, Shizhong ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Beneficial mutations; Molecular evolution; Mutation accumulation

Indexed keywords

EVOLUTION; EXON; GENETIC MODEL; INTRON; MUTATION; POPULATION GENETICS;

EID: 7344226240     PISSN: 00166707     EISSN: None     Source Type: Journal    
DOI: 10.1023/a:1017092429272     Document Type: Article

References (31)

1. Crow, J.F., 1970. Genetic loads and the cost of natural selection on. pp. 128-177 Mathematical Topics in Population Genetics, edited by K. Kojima, Springer-Verlag, Heidelberg.
2. Fisher, R.A., 1930. The Genetical Theory of Natural Selection Clarendon Press. Oxford.
3. Gillespie, J.H., 1991. The Causes of Molecular Evolution. Oxford University Press. New York.
4. Gillespie, J.H., 1993. Substitution processes in molecular evolution. I. Uniform and clustered substitutions in ahaploid model. Genetics 134: 971-981.
5. Gillespie, J.H., 1994a. Alternatives to the neutral theory: pp. 1-17 Non-neutral Evolution. Theories and Molecular Data, edidted by B. Golding, Chapman Hall. New York. pp. 1-17.
6. Gillespie, J.H., 1994b. Substitution processes in molecular evolution. II. Exchangeable models from populations genetics. Evolution 48: 1101-1113.
7. Gillespie, J.H., 1994c. Substitution processes in molecular evolution. III. Deleterious alleles. Genetics 138: 943-952.
8. Gillespie, J.H., 1995. On Ohta's hypothesis: most amino acid substitutions are deleterious. J. Mol. Evol. 40: 64-69.
9. Haldane, J.B.S., 1932. The Causes of Evolution, Longmans, Green: London (1990 edition Princeton University Press. Princeton, NJ).
10. Haldane, J.B.S., 1937. The effect of variation on fitness. American Naturalist 71: 337-349.
11. Keightley, P., 1996. Nature of deleterious mutation load in Drosophila. Genetics 144: 1993-1999.
12. Kimura, M., 1983. The Neutral Theory of Molecular Evolution. Cambridge University Press. Cambridge.
13. Kimura, M., T. Maruyama & J. F. Crow, 1963. The mutation load in small populations. Genetics 48: 1303-1312.
14. Kingman, J.F.C., 1978. A simple model for the balance between selection and mutation. J. Appl. Prob. 15: 1-12.
15. Kreitman, M., 1995. The neutral theory is dead. Long live the neutral theory. BioEssays 18: 678-682.
16. Leigh, E.G. Jr., 1987. Ronald Fisher and the development of evolutionary theory. II. Influences of new variation on evolutionary process, pp. 212-263 Oxford Surveys in Evolutionary Biology, edited by P. H. Harvey & L. Partridge. Oxford University Press. Oxford 4: 212-263.
17. Lewin, B., 1994. Genes V. Oxford University Press. Oxford.
18. Lynch, M., J. Conery & R. Bürgen. 1995. Mutation accumulation and the extinction of small populations. American Naturalist 146: 489-518.
19. Maruyama, T. & M. Kimura, 1974. A note on the speed of gene frequency changes in reverse directions in a finite population. Evolution 28: 161-163.
20. Mukai, T., 1964. The genetic structure of natural populations of Drosophila melanogaster. I. Spontaneous mutation rate of polygenes controlling viability. Genetics 50: 1-19.
21. Ohta, T., 1972. Evolutionary rate of cistrons and DNA divergence. J. Molec. Evol. 1: 150-157.
22. Ohta, T., 1973. Slightly deleterious mutant substitutions in evolution. Nature 246: 96-98.
23. Ohta, T., 1977. Extension to the neutral mutation random drift hypothesis, pp. 148-167 Molecular Evolution and Polymorphism, edited by M. Kimura. National Institutes of Genetics. Mishima.
24. Ohta, T., 1995. The current significance and standing of neutral and nearly neutral theories. BioEssays 18: 673-677.
25. Ohta, T. & M. Kimura, 1971. On the constancy of the evolutionary rate of cistrons. J. Mol. Evol. 1: 18-25.
26. Ohta, T. & H. Tachida, 1990. Theoretical study near neutrality. I. Heterozygousity and rate of mutant substitution. Genetics 126: 219-229.
27. th ed. R. Faulder & Son. London. Chptr 1 ff.
28. Peck, J.R., G. Barreau & S.C. Heath, 1997. Imperfect genes. Fisheri- an mutation and the evolution of sex. Genetics 145: 1171-1199.
29. Simmons, M.J. & J.F Crow, 1977. Mutations affecting fitness in Drosophila populations. Annual Review of Genetics 11: 49-78.
30. Takahata, T., 1987. On the overdispersed molecular clock. Genetics 116: 169-179.
31. Wagner, G.P. & W. Gabriel, 1990. Quantitative variation in finite parthenogenetic populations: what stops Muller's ratchet in the absence of recombination? Evolution 44: 715-731.