The amount and pattern of DNA polymorphism under the neutral mutation hypothesis

Genetica

Volumn 102-103, Issue , 1998, Pages 103-107

  Tajima, Fumio ^a   Misawa, Kazuharu ^a   Innan, Hideki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

DNA polymorphism; Finite site model; Heterogeneity of mutation rate; Infinite site model; Neutral theory

Indexed keywords

EID: 7344223313     PISSN: 00166707     EISSN: None     Source Type: Journal    
DOI: 10.1023/a:1017011631572     Document Type: Article

References (19)

1. Fu, Y.-X. & W.-H. Li, 1993. Statistical tests of neutrality of mutations. Genetics 133: 693-709.
2. Golding, G.B., 1983. Estimates of DNA and protein sequence divergence: an examination of some assumptions. Mol. Biol. Evol. 1: 125-142.
3. Hudson, R.R., 1990. Gene genealogies and the coalescent process. Oxf. Surv. Evol. Biol. 7: 1-44.
4. Innan, H. & F. Tajima, 1997. The amounts of nucleotide variation within and between allelic classes, and the reconstruction of the common ancestral sequence in a population. Genetics 147: 1431-1444.
5. Jukes, T.H. & C.R. Cantor: 1969. Evolution of protein molecules, pp. 21-132 in Mammalian Protein Metabolism, edited by H.N. Munro. Academic Press, New York.
6. Kimura, M., 1968. Evolutionary rate at the molecular level. Nature 217: 624-626.
7. Kimura, M., 1969. The number of heterozygous nucleotide sites maintained in a finite population due to steady flux of mutations. Genetics 61: 893-903.
8. Kimura, M., 1983. The Neutral Theory of Molecular Evolution. Cambridge Univ. Press, Cambridge.
9. Misawa, K. & F. Tajima, 1997. Estimation of the amount of DNA polymorphism when the neutral mutation rate varies among sites. Genetics 147: 1959-1964.
10. Nei, M. & W.-H. Li, 1979. Mathematical model for studying genetic variation in terms of restriction endonucleases. Proc. Natl. Acad. Sci. USA 76: 5269-5273.
11. Nei, M. & F. Tajima, 1981. DNA polymorphism detectable by restriction endonucleases. Genetics 97: 145-163.
12. Tajima, F., 1983. Evolutionary relationship of DNA sequences in finite populations. Genetics 105: 437-460.
13. Tajima, F., 1989. Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. Genetics 123: 585-595.
14. Tajima, F., 1993a. Measurement of DNA polymorphism, pp. 37-59 in Mechanisms of Molecular Evolution, edited by N. Takahata & A. G. Clark. Japan Sci. Soc. Press, Tokyo/Sinauer Associates, Sunderland, MA.
15. Tajima, F., 1993b. Statistical analysis of DNA polymorphism. Jpn. J. Genet. 68: 567-595.
16. Tajima, F., 1996. The amount of DNA polymorphism maintained in a finite population when the neutral mutation rate varies among sites. Genetics 143: 1457-1465.
17. Wakeley, J., 1993. Substitution rate variation among sites in hypervariable region 1 of human mitochondrial DNA. J. Mol. Evol. 37: 613-623.
18. Watterson, G.A., 1975. On the number of segregating sites in genetic models without recombination. Theor. Popul. Biol. 7: 256-276.
19. Yang, Z., 1996. Statistical properties of a DNA sample under the finite-sites model. Genetics 144: 1941-1950.