Evidence for the presence of muscarinic M2 and M4 receptors in guinea-pig gallbladder smooth muscle

Journal of Autonomic Pharmacology

Volumn 18, Issue 4, 1998, Pages 195-204

  Oktay, S ^a,e   Cabadak, H ^a   Iskender, E ^a   Goren Z ^a   Caliskan E ^a   Orun, O ^a   Aslan, N ^a   Karaalp, A ^a   Tolun, A ^b   Ulusoy, N B ^a   Levey, A I ^c   El Fakahany, E E ^d   Kan, B ^a  

^a MARMARA UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b BOGAZICI UNIVERSITY   (Turkey)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^e MARMARA UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

11 [[4 [4 (DIETHYLAMINO)BUTYL] 1 PIPERIDYL]ACETYL] 5,11 DIHYDRO 6H PYRIDO[2,3 B][1,4]BENZODIAZEPIN 6 ONE; 4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; ADENYLATE CYCLASE; CARBACHOL; CYCLIC AMP; METHOCTRAMINE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; N [2 [2 (DIPROPYLAMINOMETHYL) 1 PIPERIDYL]ETHYL] 5,11 DIHYDRO 6 OXO 6H PYRIDO[2,3 B][1,4]BENZODIAZEPINE 11 CARBOXAMIDE; OTENZEPAD; PHOSPHATIDYLINOSITIDE; PIRENZEPINE; QUINUCLIDINYL BENZILATE;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; GALLBLADDER; GALLBLADDER CONTRACTION; GUINEA PIG; HYDROLYSIS; IMMUNOBLOTTING; MALE; NONHUMAN; SMOOTH MUSCLE;

EID: 7344220968     PISSN: 01441795     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2680.1998.18474.x     Document Type: Article

References (59)

1. 2 muscarinic receptor subtype coupled to both adenylate cyclase and phosphoinositide turnover. Science, 238, 672-675.
2. BAROCELLI, E., BALLABENI, V., CHIAVARINI, M., MOLINA, E. & IMPICCIATORE, M. (1994). Functional comparison between nuvenzepine and pirenzepine on different guinea-pig isolated smooth muscle preparations. Pharmacol. Res., 30, 161-170.
3. BERRIDGE, M.J. (1983). Rapid accumulation of inositol triphosphate reveals that agonists hydrolyse phosphoinositides instead of phosphatidylinositol. Biochem. J., 212, 849-858.
4. BONNER, T.I. (1989). New subtypes of muscarinic acetylcholine receptors. Trends Pharmacol. Sci., 10 (Suppl.), 11-15.
5. BONNER, T.I., BUCKLEY, N.J., YOUNG, A.C. & BRANN, M.R. (1987). Identification of a family of muscarinic acetylcholine receptor genes. Science, 237, 527-532.
6. 5 muscarinic acetylcholine receptor genes. Neuron, 1, 403-410.
7. BROWN, J.H. & BROWN, S.L. (1984). Agonists differentiate muscarinic receptors that inhibit cAMP formation from those that stimulate phosphoinositide metabolism. J. Biol. Chem., 259, 3777-3781.
8. BUCKLEY, N.J., BONNER, T.I., BUCKLEY, C.M. & BRANN, M.R. (1989). Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells. Mol. Pharmacol., 35, 469-476.
9. CANDELL, L.M., YUN, S.H., TRAN, L.L.P. & EHLERT, F.J. (1990). Differential coupling of subtypes of the muscarinic receptor to adenylate cyclase and phosphoinositide hydrolysis in the longitudinal muscle of the rat ileum. Mol. Pharmacol., 38, 689-697.
10. 50) of an enzymatic reaction. Biochem. Pharmacol., 22, 3099-3108.
11. CHEN, Q., YU, P., DE PETRIS, G., BIANCANI, P. & BEHAR, J. (1995). Distinct muscarinic receptors and signal transduction pathways in gallbladder muscle. J. Pharmacol. Exp. Ther., 273, 650-655.
12. 3 muscarinic receptors in rat parotid gland couple to two second messenger systems. Am. J. Physiol., 30, C1063-C1073.
13. DE LEAN, A., HANCOCK, A.A. & LEFKOWITZ, R.J. (1981). Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes. Mol. Pharmacol., 21, 5-16.
14. 3 receptors. J. Pharmacol Exp. Ther., 242, 257-262.
15. DOODS, H.N., WILLIM, K.D., BODDEKE, H.W.G.M. & ENTZEROTH, M. (1993a). Characterization of muscarinic receptors in guinea-pig uterus. Eur. J. Pharmacol., 250, 223-230.
16. 2 receptor antagonist. Eur. J. Pharmacol., 242, 23-30.
17. DÖRJE, F., WESS, J., LAMBRECHT, G., TACKE, R., MUTSCHLER, E. & BRANN, M.R. (1991a). Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J. Pharmacol. Exp. Ther., 256, 727-733.
18. 5) in rabbit peripheral tissues. Mol. Pharmacol., 40, 459-462.
19. EGLEN, R.M. & WHITING, R.L. (1990). Heterogeneity of vascular muscarinic receptors. J. Auton. Pharmacol., 10, 233-245.
20. EGLEN, R.M., MICHEL, A.D. & WHITING, R.L. (1989). Characterization of the muscarinic receptor subtype mediating contractions of the guinea-pig uterus. Br. J. Pharmacol., 96, 497-499.
21. EGLEN, R.M., MICHEL, A.D., LEVINE, W.B. & WHITING, R.L. (1991). Analysis of muscarinic receptors in guinea-pig estrogen-dominated uterus, in vitro. Br. J. Pharmacol., 104, 44P.
22. EGLEN, R.M., REDDY, H., WATSON, N. & CHALLISS, R.A.J. (1994). Muscarinic acetylcholine receptor subtypes in smooth muscle. Trends Pharmacol. Sci., 15, 114-119.
23. EGLEN, R.M., HEGDE, S.S. & WATSON, N. (1996). Muscarinic receptor subtypes and smooth muscle function. Pharmacol. Rev., 48, 531-565.
24. 3H]AF-DX 384 to rat ileal smooth muscle muscarinic receptors. Recept. Res., 11, 141-152.
25. ENTZEROTH, M., DOODS, H.N. & MAYER, N. (1990). Characterization of porcine coronary muscarinic receptors. Naunyn-Schmiedeberg's Arch. Pharmacol., 341, 432-438.
26. FELDER, C.C. (1995). Muscarinic acetylcholine receptors: signal transduction through multiple effectors. FASEB J., 9, 619-625.
27. FORD, A.P.D.W., LEVINE, W.B., BAXTER, G.S., HARRIS, G.C., EGLEN, R.M. & WHITING, R.L. (1991). Pharmacological, biochemical and molecular characterization of muscarinic receptors in the guinea-pig ileum: a multidisciplinary study. Mol. Neuropharmacol., 1, 117-127.
28. GIL, D.W. & WOLFE, B.B. (1985). Pirenzepine distinguishes between muscarinic receptor-mediated phosphoinositide breakdown and inhibition of adenylate cyclase. J. Pharmacol. Exp. Ther., 232, 608-616.
29. GIRALDO, E., MONFERINI, E., LADINSKY, H. & HAMMER, R. (1987). Muscarinic receptor heterogeneity in guinea-pig intestinal smooth muscle: binding studies with AF-DX 116. Eur. J. Pharmacol., 141, 475-477.
30. 2-receptor subtypes for agonists and antagonists in porcine gastric smooth muscle and mucosa. Gastroenterology, 94, 630-637.
31. 4 muscarinic receptor proteins in the rat striatum: light and electron microscopic immunocytochemistry using subtype specific antisera. J. Neurosci., 14, 3351-3363.
32. HULME, E.C., BIRDSALL, N.J.M. & BUCKLEY, N.J. (1990). Muscarinic receptor subtypes. Annu. Rev. Pharmacol. Toxicol., 30, 633-673.
33. KURTEL, H., YEǦEN, B.Ç., DEDEOǦLU, A., ULUSOY, N.B. & OKTAY, Ş. (1990). Muscarinic receptor subtypes of guinea-pig gallbladder smooth muscle. Arch. Int. Pharmacodyn. Ther., 308, 39-46.
34. LAMBRECHT, G., MOSER, U., GRIMM, U., PFAFF, O., HERMANNI, U., HILDEBRANDT, C., WAELBROECK, M., CHRISTOPHE, J. & MUTSCHLER, E. (1993). New functionally selective muscarinic agonists. Life Sci., 52, 481-488.
35. 35S]-GTPγS binding mediated by human muscarinic m1-m4 receptors: antagonist studies. Br. J. Pharmacol., 109, 1120-1127.
36. 4 binding sites in rabbit lung, chicken heart, and NG108-15 cells. Mol. Pharmacol., 38, 805-815.
37. LEIBER, D., SYLVIE, M. & HARBON, S. (1990). Pharmacological evidence for distinct muscarinic subtypes coupled to the inhibition of adenylate cyclase and to the increased generation of inositol phosphates in the guinea-pig myometrium. J. Pharmacol. Exp. Ther., 252, 800-809.
38. LEVEY, A.I., KITT, C.A., SIMONDS, W.F., PRICE, D.L. & BRANN, M.R. (1991). Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies. J. Neurosci., 11, 3218-3226.
39. LOWRY, O.H., ROSENBROUGH, N.J., FARR, A.L. & RANDALL, R.J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275.
40. LUCARBACHOLESI, P.A., SCHEID, C.R., ROMANO, F.D., KARGACIN, M.E., MULLIKIN-KILPATRICK, D., YAMAGUCHI, H. & HONEYMAN, T.W. (1990). Ligand binding and G protein coupling of muscarinic receptors in airway smooth muscle. Am. J. Physiol., 258, C730-C738.
41. MAEDA, A., KUBO, T., MISHINA, M. & NUMA, S. (1988). Tissue distribution of mRNAs encoding muscarinic acetylcholine receptor subtypes. FEBS Lett., 239, 339-342.
42. 4 muscarinic receptor subtypes mediating cyclic AMP inhibition. Mol. Pharmacol., 40, 1014-1022.
43. 2 muscarinic receptors in longitudinal ileal smooth muscle membranes. Eur. J. Pharmacol., 145, 305-311.
44. 3H]4-diphenylacetoxy-N-methylpiperidine methiodide to longitudinal ileal smooth muscle muscarinic receptors. Eur. J. Pharmacol., 176, 197-205.
45. MICHEL, A.D., DELMONDO, R., STEFANICH, E. & WHITING, R.L. (1989). Binding characteristics of the muscarinic receptor subtype of the NG108-15 cell line. Naunyn-Schmiedeberg's Arch. Pharmacol., 340, 62-67.
46. 4 subtype? Pharmacology, 46, 308-314.
47. PARKER, E.M., KAMEYAMA, K., HIGASHIJIMA, T. & ROSS, E.M. (1991). Reconstitutively active G-protein-coupled receptors purified from baculovirus-infected insect cells. J. Biol. Chem., 266, 519-527.
48. PERALTA, E.G., ASHKENAZI, A., WINSLOW, J.W., SMITH, D.H., RAMACHANDRAN, J. & CAPON, D.J. (1987). Distinct primary structures, ligand binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. EMBO J., 6, 3923-3929.
49. PERALTA, E.G., ASHKENAZI, A., WINSLOW, J.W., RAMACHANDRAN, J. & CAPON, D.J. (1988). Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes. Nature, 334, 434-437.
50. 2-like receptors. Eur. J. Pharmacol., 250, 267-279.
51. 1 muscarinic receptors mediate both adenylate cyclase inhibition and phosphoinositide turnover. EMBO J., 7, 3031-3035.
52. 3 receptor in guinea-pig gallbladder. Am. J. Physiol., 267, G523-G528.
53. VAN CHARLDORP, K.J. & VAN ZWIETEN, P.A. (1989). Comparison of the muscarinic receptors in the coronary artery, cerebral artery and atrium of the pig, Naunyn-Schmiedeberg's Arch. Pharmacol., 339, 403-408.
54. VON SCHRENCK, T., SIEVERS, J., MIRAU, S., RAEDLER, A. & GRETEN, H. (1993). Characterization of muscarinic receptors on guinea-pig gallbladder smooth muscle. Gastroenterology, 105, 1341-1349.
55. VON SCHRENCK, T., MACKENSEN, B., MENDE, U., SCHMITZ, W., SIEVERS, J., MIRAU, S., RAEDLER, A. & GRETEN, H. (1994). Signal transduction pathway of the muscarinic receptors mediating gallbladder contraction. Naunyn-Schmiedeberg's Arch. Pharmacol., 349, 346-354.
56. 4 muscarinic receptor subtypes. Br. J. Pharmacol., 105, 97-102.
57. YAMAMURA, H.I. & SOLOMON, H.S. (1974). Muscarinic cholinergic binding in rat brain. Proc. Natl. Acad. Sci., 71, 1725-1729.
58. ZHANG, L. & BUXTON, I.L.O. (1991). Muscarinic receptors in canine colonic circular smooth muscle. II. Signal transduction pathways. Mol. Pharmacol., 40, 952-959.
59. 3 subtypes. Mol. Pharmacol., 40, 943-951.