Locally applied osteogenic predifferentiated progenitor cells are more effective than undifferentiated mesenchymal stem cells in the treatment of delayed bone healing

Tissue Engineering - Part A

Volumn 15, Issue 10, 2009, Pages 2947-2954

  Peters, Anja ^a   Toben, Daniel ^a   Lienau, Jasmin ^a   Schell, Hanna ^a   Bail, Hermann J ^a   Matziolis, Georg ^a   Duda, Georg N ^a   Kaspar, Katharina ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; BIOMECHANICS; BONE; CELL CULTURE; FLOWCHARTING; RADIOLOGY;

BONE DEFECT; BONE HEALING; BONE MARROW; CELL-FREE; CONTROL GROUPS; EXTERNAL FIXATOR; MESENCHYMAL STEM CELL; MINIMALLY INVASIVE TREATMENTS; OSTEOGENIC; PROGENITOR CELL; REGENERATIVE CAPACITY;

STEM CELLS;

ANIMALIA; RATTUS;

ANIMAL; ARTICLE; BONE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CYTOLOGY; INJURY; MALE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; METHODOLOGY; OSTEOTOMY; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; STEM CELL; STEM CELL TRANSPLANTATION; WOUND HEALING;

ANIMALS; BONE AND BONES; CELL DIFFERENTIATION; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; OSTEOGENESIS; OSTEOTOMY; RATS; RATS, SPRAGUE-DAWLEY; STEM CELL TRANSPLANTATION; STEM CELLS; WOUND HEALING;

EID: 73349138928     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2009.0058     Document Type: Article

References (34)

1. Braun, W., and Ruter, A. Fracture healing. Morphologic and physiologic aspects. Unfallchirurg 99, 59, 1996.
2. Arrington, E.D., Smith, W.J., Chambers, H.G., Bucknell, A.L., and Davino, N.A. Complications of iliac crest bone graft harvesting. Clin Orthop Relat Res 329, 300, 1996.
3. Matziolis, G., Winkler, T., Schaser, K., Wiemann, M., Krocker, D., Tuischer, J., Perka, C., and Duda, G.N. Auto-logous bone marrow-derived cells enhance muscle strength following skeletal muscle crush injury in rats. Tissue Eng 12, 361, 2006.
4. Jorgensen, C., Gordeladze, J., and Noel, D. Tissue engi-neering through autologous mesenchymal stem cells. Curr Opin Biotechnol 15, 406, 2004.
5. Ringe, J., Haupl, T., and Sittinger, M. Mesenchymal stem cells for tissue engineering of bone and cartilage. Med Klin (Munich) 98 Suppl 2, 35, 2003.
6. Jaiswal, N., Haynesworth, S.E., Caplan, A.I., and Bruder, S.P. Osteogenic differentiation of purified, culture-expanded hu-man mesenchymal stem cells in vitro. J Cell Biochem 64, 295, 1997.
7. Bruder, S.P., Kraus, K.H., Goldberg, V.M., and Kadiyala, S. The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects. J Bone Joint Surg Am 80, 985, 1998.
8. Petite, H., Viateau, V., Bensaid, W., Meunier, A., de Pollak, C., Bourguignon, M., Oudina, K., Sedel, L., and Guillemin, G. Tissue-engineered bone regeneration. Nat Biotechnol 18,959, 2000.
9. Einhorn, T.A. The cell and molecular biology of fracture healing. Clin Orthop Relat Res 355 Suppl, 7, 1998.
10. Pittenger, M.F., Mackay, A.M., Beck, S.C., Jaiswal, R.K., Douglas, R., Mosca, J.D., Moorman, M.A., Simonetti, D.W., Craig, S., and Marshak, D.R. Multilineage potential of adult human mesenchymal stem cells. Science 284, 143, 1999.
11. Hernigou, P., and Beaujean, F. Abnormalities in the bone marrow of the iliac crest in patients who have osteonecrosis secondary to corticosteroid therapy or alcohol abuse. J Bone Joint Surg Am 79, 1047, 1997.
12. Makino, T., Hak, D.J., Hazelwood, S.J., Curtiss, S., and Reddi, A.H. Prevention of atrophic nonunion development by recombinant human bone morphogenetic protein-7. J Orthop Res 23, 632, 2005.
13. Kon, E., Muraglia, A., Corsi, A., Bianco, P., Marcacci, M., Martin, I., Boyde, A., Ruspantini, I., Chistolini, P., Rocca, M. Giardino, R., Cancedda, R., and Quarto, R. Autologous bone marrow stromal cells loaded onto porous hydroxyapatite ceramic accelerate bone repair in critical-size defects of sheep long bones. J Biomed Mater Res 49, 328, 2000.
14. Yamada, Y., Ueda, M., Naiki, T., Takahashi, M., Hata, K., and Nagasaka, T. Autogenous injectable bone for regenera-tion with mesenchymal stem cells and platelet-rich plasma: tissue-engineered bone regeneration. Tissue Eng 10, 955, 2004.
15. Connolly, J.F., Guse, R., Tiedeman, J., and Dehne, R. Auto-logous marrow injection for delayed unions of the tibia: a preliminary report. J Orthop Trauma 3, 276, 1989.
16. Paley, D., Young, M.C., Wiley, A.M., Fornasier, V.L., and Jackson, R.W. Percutaneous bone marrow grafting of frac-tures and bony defects. An experimental study in rabbits. Clin Orthop Relat Res 208, 300, 1986.
17. Devine, M.J., Mierisch, C.M., Jang, E., Anderson, P.C., and Balian, G. Transplanted bone marrow cells localize to fracture callus in a mouse model. J Orthop Res 20, 1232, 2002.
18. Kaspar, K., Matziolis, G., Strube, P., Senturk, U., Dormann, S., Bail, H.J., and Duda, G.N. A new animal model for bone atrophic nonunion: fixation by external fixator. J Orthop Res 26, 1649, 2008.
19. Hernigou, P., and Beaujean, F. Bone marrow in patients with pseudarthrosis. A study of progenitor cells by in vitro cloning. Rev Chir Orthop Reparatrice Appar Mot 83, 33, 1997.
20. Sethe, S., Scutt, A., and Stolzing, A. Aging of mesenchymal stem cells. Ageing Res Rev 5, 91, 2006.
21. Kaspar, K., Schell, H., Toben, D., Matziolis, G., and Bail, H.J. An easily reproducible and biomechanically standardized model to investigate bone healing in rats, using external fixation. Biomed Tech (Berl) 52, 383, 2007.
22. Harting, M., Jimenez, F., Pati, S., Baumgartner, J., and Cox, C., Jr. Immunophenotype characterization of rat mesenchy-mal stromal cells. Cytotherapy 10, 243, 2008.
23. Ferrari, M., Corradi, A., Lazzaretti, M., De'Cilla, M., Losi, C.G., Villa, R., and Lanfranchi, A. Adult stem cells: per-spectives for therapeutic applications. Vet Res Commun 31 Suppl 1, 1, 2007.
24. Movat, H.Z. Demonstration of all connective tissue elements in a single section; pentachrome stains. AMA Arch Pathol 60, 289, 1955.
25. McKibbin, B. The biology of fracture healing in long bones. J Bone Joint Surg Br 60-B, 150, 1978.
26. Street, J., Winter, D., Wang, J.H., Wakai, A., McGuinness, A., and Redmond, H.P. Is human fracture hematoma inherently angiogenic? Clin Orthop Relat Res 378, 224, 2000.
27. Tsunoda, M., Mizuno, K., and Matsubara, T. The osteogenic potential of fracture hematoma and its mechanism on bone formation\through fracture hematoma culture and trans-plantation of freeze-dried hematoma. Kobe J Med Sci 39, 35, 1993.
28. Probst, A., and Spiegel, H.U. Cellular mechanisms of bone repair. J Invest Surg 10, 77, 1997.
29. Brighton, C.T., and Hunt, R.M. Early histologic and ultra-structural changes in microvessels of periosteal callus. J Orthop Trauma 11, 244, 1997.
30. Cruess, R.L., and Dumont, J. Fracture healing. Can J Surg 18, 403, 1975.
31. Song, L., and Tuan, R.S. Transdifferentiation potential of human mesenchymal stem cells derived from bone marrow. FASEB J 18, 980, 2004.
32. Hak, D.J., Makino, T., Niikura, T., Hazelwood, S.J., Curtiss, S., and Reddi, A.H. Recombinant human BMP-7 effectively prevents non-union in both young and old rats. J Orthop Res 24, 11, 2006.
33. Winkler, T., Von Roth, P., Schumann, M.R., Sieland, K., Stoltenburg-Didinger, G., Taupitz, M., Perka, C., Duda, G.N., and Matziolis, G. In vivo visualization of locally trans-planted mesenchymal stem cells in the severely injured muscle in rats. Tissue Eng A 14, 1149, 2008.
34. Betz, O.B., Betz, V.M., Nazarian, A., Egermann, M., Ger-stenfeld, L.C., Einhorn, T.A., Vrahas, M.S., Bouxsein, M.L., and Evans, C.H. Delayed administration of adenoviral BMP-2 vector improves the formation of bone in osseous defects. Gene Ther 14, 1039, 2007