Case report: PCR detection of histoplasma capsulatum var. capsulatum in whole blood of a renal transplant patient with disseminated histoplasmosis

Annals of Clinical and Laboratory Science

Volumn 39, Issue 4, 2009, Pages 409-412

  Qualtieri, Julianne ^a   Stratton, Charles W ^a   Head, David R ^a   Tang, Yi Wei ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Histoplasma capsulatum; Histoplasmosis; PCR EIA

Indexed keywords

AMPHOTERICIN B LIPID COMPLEX; ITRACONAZOLE;

ADULT; ARTICLE; CASE REPORT; COLORIMETRY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; FEVER; FUNGAL DETECTION; FUNGUS IDENTIFICATION; GRAFT INFECTION; HISTOPLASMA CAPSULATUM; HISTOPLASMOSIS; HUMAN; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; KIDNEY TRANSPLANTATION; PLEURA EFFUSION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEPSIS; THORAX RADIOGRAPHY; BLOOD; GENETICS; HISTOPLASMA; ISOLATION AND PURIFICATION; METHODOLOGY; MICROBIOLOGY; STAINING;

AJELLOMYCES CAPSULATUS; HISTOPLASMA CAPSULATUM VAR. CAPSULATUM;

ADULT; FEMALE; HISTOPLASMA; HISTOPLASMOSIS; HUMANS; KIDNEY TRANSPLANTATION; POLYMERASE CHAIN REACTION; STAINING AND LABELING;

EID: 73349123459     PISSN: 00917370     EISSN: 15508080     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Tang YW, Sefers SE, Li HJ, Kohn DL, Procop GW. Comparative evaluation of three commercial systems for nucleic acid extraction in urine specimens. J Clin Microbiol 2005;43:4830-4833.
2. Tang YW, Li H, Durkin MM, Sefers SE, Meng S, Connolly PA, Stratton CW, Wheat LJ. Urine polymerase chain reaction is not as sensitive as urine antigen for the diagnosis of disseminated histoplasmosis. Diagn Microbiol Infect Dis 2006;54:283-287.
3. Porta A, Colonna-Romano S, Callebaut I, Franco A, Marzullo L, Kobayashi GS, Maresca B. An homologue of the human 100-kDa protein (p100) is differentially expressed by Histoplasma capsulatum during infection of murine macrophages. Biochem Biophys Res Commun 1999;254:605-613.
4. Durkin MM, Connolly PA, Wheat LJ. Comparison of radioimmunoassay and enzyme-linked immunoassay methods for detection of Histoplasma capsulatum var. capsulatum antigen. J Clin Microbiol 1997;35:2252-2255.
5. Wheat LJ, Connolly P, Durkin M, Book BK, Pescovitz MD. Elimination of false-positive Histoplasma antigenemia caused by human anti-rabbit antibodies in the second-generation Histoplasma antigen assay. Transpl Infect Dis 2006;8:219-221.
6. Silveira FP, Husain S. Fungal infections in solid organ transplantation. Med Mycol 2007;45:305-320.
7. Kauffman CA. Histoplasmosis: a clinical and laboratory update. Clin Microbiol Rev 2007;20:115-132.
8. Cloud JL, Bauman SK, Neary BP, Ludwig KG, Ashwood ER. Performance characteristics of a polyclonal enzyme immunoassay for the quantitation of Histoplasma antigen in human urine samples. Am J Clin Pathol 2007;128:18-22.
9. Wheat LJ, Wheat H, Connolly P, Kleiman M, Supparatpinyo K, Nelson K, Bradsher R, Restrepo A. Crossreactivity in Histoplasma capsulatum variety capsulatum antigen assays of urine samples from patients with endemic mycoses. Clin Infect Dis 1997;24:1169-1171.
10. Bialek R, Feucht A, Aepinus C, Just-Nubling G, Robertson VJ, Knobloch J, Hohle R. Evaluation of two nested PCR assays for detection of Histoplasma capsulatum DNA in human tissue. J Clin Microbiol 2002;40: 1644-1647.
11. Collins MH, Jiang B, Croffie JM, Chong SK, Lee CH. Hepatic granulomas in children. A clinicopathologic analysis of 23 cases including polymerase chain reaction for Histoplasma. Am J Surg Pathol 1996;20:332-338.
12. Imhof A, Schaer C, Schoedon G, Schaer DJ, Walter RB, Schaffner A, Schneemann M. Rapid detection of pathogenic fungi from clinical specimens using LightCycler real-time fluorescence PCR. Eur J Clin Microbiol Infect Dis 2003;22:558-560.
13. Bracca A, Tosello ME, Girardini JE, Amigot SL, Gomez C, Serra E. Molecular detection of Histoplasma capsulatum var. capsulatum in human clinical samples. J Clin Microbiol 2003;41:1753-1755.
14. Guiot HM, Bertran-Pasarell J, Tormos LM, Gonzalez-Keelan C, Procop GW, Fradera J, Sanchez-Sergenton C, Mendez W. Ileal perforation and reactive hemophagocytic syndrome in a patient with disseminated histoplasmosis: the role of the real-time polymerase chain reaction in the diagnosis and successful treatment with amphotericin B lipid complex. Diagn Microbiol Infect Dis 2007;57:429-433.
15. Lo Cascio G, Ligozzi M, Maccacaro L, Rizzonelli P, Fontana R. Diagnostic aspects of cutaneous lesions due to Histoplasma capsulatum in African AIDS patients in nonendemic areas. Eur J Clin Microbiol Infect Dis 2003;22:637-638.
16. Murata M, Furusyo N, Otaguro S, Nabeshima S, Ariyama I, Hayashi J. HIV infection with concomitant cerebral toxoplasmosis and disseminated histoplasmosis in a 45-year-old man. J Infect Chemother 2007;13:51-55.
17. Spencer WH, Chan CC, Shen de F, Rao NA. Detection of Histoplasma capsulatum DNA in lesions of chronic ocular histoplasmosis syndrome. Arch Ophthalmol 2003;121:1551-1555.
18. Buitrago MJ, Berenguer J, Mellado E, Rodriguez-Tudela JL, Cuenca-Estrella M. Detection of imported histoplasmosis in serum of HIV-infected patients using a real-time PCR-based assay. Eur J Clin Microbiol Infect Dis 2006;25:665-668.
19. Rickerts V, Bialek R, Tintelnot K, Jacobi V, Just-Nubling G. Rapid PCR-based diagnosis of disseminated histoplasmosis in an AIDS patient. Eur J Clin Microbiol Infect Dis 2002;21:821-823.
20. Rivasi F, Casali B, Nanetti A, Collina G, Mazzoni A. Histoplasma capsulatum var. capsulatum occurring in an HIV-positive Ghanaian immigrant to Italy. Identification of H. capsulatum DNA by PCR from paraffin sample. Apmis 2001;109:721-725.
21. Martagon-Villamil J, Shrestha N, Sholtis M, Isada CM, Hall GS, Bryne T, Lodge BA, Reller LB, Procop GW. Identification of Histoplasma capsulatum from culture extracts by real-time PCR. J Clin Microbiol 2003;41: 1295-1298.