Spontaneous iron accumulation in hepatocytes of a 7-week-old female rat

Journal of Toxicologic Pathology

Volumn 22, Issue 3, 2009, Pages 199-203

  Miyata, Kaori ^a   Sukata, Tokuo ^a   Kushida, Masahiko ^a   Ogata, Keiko ^a   Suzuki, Manabu ^b   Ozaki, Masakazu ^b   Ozaki, Keisuke ^a   Uwagawa, Satoshi ^a  

^a SUMITOMO CHEMICAL CO LTD   (Japan)

^b Hamamatsu University School of Medicine   (Japan)

Author keywords

Hepatocyte; Iron accumulation; Iron overload; Rats; Spontaneous

Indexed keywords

FERRIC FERROCYANIDE; FERRITIN; HEMOSIDERIN; IRON;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; FEMALE; HEMOCHROMATOSIS; IRON METABOLISM; IRON OVERLOAD; LIVER; LIVER CELL; NONHUMAN; RAT; STAINING; TRANSMISSION ELECTRON MICROSCOPY; WISTAR RAT;

EID: 73349115211     PISSN: 09149198     EISSN: None     Source Type: Journal    
DOI: 10.1293/tox.22.199     Document Type: Article

References (10)

1. Batts KP. Iron overload syndromes and the liver. Modern Pathology. 20: S31-S39. 2007.
2. Iancu TC, Deugnier Y, Halliday JW, Powell LW, and Brissot P. Ultrastructural sequences during liver iron overload in genetic hemochromatosis. J Hepatol. 27: 628-638. 1997.
3. Masson R and Roome NO. Spontaneous iron overload in Sprague-Dawley rats. Toxicol Pathol. 25: 308-316. 1997.
4. Ward RJ, Florence AL, Baldwin D, Abiaka C, Roland F, Ramsey MH, Dickson DP, Peters TJ, and Crichton RR. Biochemical and biophysical investigations of the ferrocene-iron-loaded rat. An animal model of primary haemochromatosis. Eur J Biochem. 202: 405-410. 1991.
5. Whittaker P, Hines FA, Robl MG, and Dunkel VC. Histopathological evaluation of liver, pancreas, spleen, and heart from iron-overloaded Sprague-Dawley rats, Toxicol Pathol. 24: 558-563. 1996.
6. Williams GM and Yamamoto RS. Absence of stainable iron from preneoplastic and neoplastic lesions in rat liver with 8-hydroxyquinoline-induced siderosis. J Natl Cancer Inst. 49: 685-692. 1972.
7. Powell LW, McKeering LV, and Halliday JW. Alterations in tissue ferritins in iron storage disorders. Gut. 16: 909-912. 1975.
8. Hirayama M, Kohgo Y, Kondo H, Shintani N, Fujikawa K, Sasaki K, Kato J, and Niitsu Y. Regulation of iron metabolism in HepG2 cells: a possible role for cytokines in the hepatic deposition of iron. Hepatology. 18: 874-880. 1993.
9. Lefkowitch JH, Yee HT, Sweeting J, Green PH, and Magun AM. Iron-rich foci in chronic viral hepatitis. Hum Pathol. 29: 116-118. 1998.
10. Ambu R, Crisponi G, Sciot R, Van Eyken P, Parodo G, Iannelli S, Marongiu F, Silvagni R, Nurchi V, Costa V, Faa G, and Desmet VJ. Uneven hepatic iron and phosphorus distribution in beta-thalassemia. J Hepatol. 23: 544-549. 1995.