Fulminant legionellosis in two patients treated with infliximab for Crohn's disease: Case series and literature review

Canadian Journal of Gastroenterology

Volumn 23, Issue 12, 2009, Pages 829-833

  Hofmann, Adam ^a   Beaulieu, Yanick ^b   Bernard, Francis ^b   Rico, Philippe ^b  

^a MCGILL UNIVERSITY   (Canada)

^b HÔPITAL DU SACRÉ COEUR DE MONTRÉAL   (Canada)

Author keywords

Crohn's disease; Infliximab; Legionella pneumophila; Tumour necrosis factor alpha

Indexed keywords

AZITHROMYCIN; CASPOFUNGIN; CIPROFLOXACIN; INFLIXIMAB; MACROLIDE; MERCAPTOPURINE; METHYLPREDNISOLONE; PIPERACILLIN PLUS TAZOBACTAM; PREDNISONE; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; VANCOMYCIN;

ABDOMINAL PAIN; ACUTE KIDNEY TUBULE NECROSIS; ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ANTIBIOTIC RESISTANCE; ANTIGEN DETECTION; ANUS FISTULA; ARTICLE; BRONCHOPLEURAL FISTULA; CASE REPORT; CASE STUDY; CEREBROVASCULAR ACCIDENT; CHRONIC DIARRHEA; CLINICAL FEATURE; COLONOSCOPY; COMPUTER ASSISTED TOMOGRAPHY; CROHN DISEASE; DISEASE COURSE; DISEASE SEVERITY; DRUG DOSE ESCALATION; FATALITY; FEVER; GENERAL CONDITION DETERIORATION; HEMODIALYSIS; HIGH FREQUENCY OSCILLATION; HUMAN; HYPOXIA; INTENSIVE CARE UNIT; KIDNEY DISEASE; LEG EDEMA; LEGIONELLA PNEUMOPHILA; LEGIONNAIRE DISEASE; LUNG BIOPSY; MALE; PNEUMOTHORAX; PRIORITY JOURNAL; RESPIRATORY FAILURE; TACHYCARDIA; TACHYPNEA; THORAX RADIOGRAPHY; VERTEBRAL ARTERY;

EID: 73349115194     PISSN: 08357900     EISSN: None     Source Type: Journal    
DOI: 10.1155/2009/836938     Document Type: Article

References (11)

1. Stout JE, Yu VL. Legionellosis. N Engl J Med 1997;337:682-7.
2. Beigel F, Jürgens M, Filik L, et al. Severe Legionella pneumophila pneumonia following infliximab therapy in a patient with Crohn's disease. Inflamm Bowel Dis 2009;15:1240-4.
3. Mancini G, Erario L, Gianfreda R, et al. Tuberculosis and Legionella pneumophila pneumonia in a patient receiving anti-tumour necrosis factor-alpha (anti-TNF-alpha) treatment. Clin Microbiol Infect 2007;13:1036-7.
4. Kohn A, Daperno M, Armuzzi A, et al. Infliximab in severe ulcerative colitis: Short-term results of different infusion regimens and long-term follow-up. Aliment Pharmacol Ther 2007;26:747-56.
5. Tubach F, Ravaud P, Salmon-Céron D, et al. Recherche Axée sur la Tolérance des Biothérapies Group. Emergence of Legionella pneumophila pneumonia in patients receiving tumor necrosis factor-alpha antagonists. Clin Infect Dis 2006;43:e95-100.
6. Li Gobbi F, Benucci M, Del Rosso A. Pneumonitis caused by Legionella pneumoniae in a patient with rheumatoid arthritis treated with anti-TNF-alpha therapy (infliximab). J Clin Rheumatol 2005;11:119-20.
7. Wondergem MJ, Voskuyl AE, van Agtmael MA. A case of legionellosis during treatment with a TNF-alpha antagonist. Scand J Infect Dis 2004;36:310-1.
8. Albert C, Vandenbos F, Brocq O, Carles D, Euller-Ziegler L. Legionellosis in patient treated with infliximab. Rev Med Intern 2004;25:167-8.
9. Eisendle K, Fritsch P. Fatal fulminant legionnaires' disease in a patient with severe erythodermic psoriasis treated with infliximab after longterm steroid therapy. Br J Dermatol 2005;152:585-6.
10. Dixon WG, Watson K, Lunt M, Hyrich KL, Silman AJ, Symmons DP; British Society for Rheumatology Biologics Register. Rates of serious infection, including site-specific and bacterial intracellular infection in rheumatoid arthritis patients receiving anti-tumor necrosis factor therapy: Results from the British Society for Rheumatology Biologics Register. Arthritis Rheum 2006;54:2368-76.
11. Friedman H, Yamamoto Y, Klein TW. Legionella pneumophila pathogenesis and immunity. Semin Pediatr Infect Dis 2002;13:273-9.