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Volumn 9, Issue 12, 2009, Pages 1737-1743

Degarelix 240/80 mg: A new treatment option for patients with advanced prostate cancer

Author keywords

Androgen deprivation therapy; Degarelix; Gonadotrophin releasing hormone; Leuprolide; Prostate cancer; Prostate specific antigen; Testosterone

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; DEGARELIX; FIRMAGON; GONADORELIN ANTAGONIST; LEUPRORELIN; PROSTATE SPECIFIC ANTIGEN; TESTOSTERONE; UNCLASSIFIED DRUG;

EID: 73349112557     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/ERA.09.150     Document Type: Review
Times cited : (10)

References (23)
  • 1
    • 33751558449 scopus 로고    scopus 로고
    • Post-therapy changes in PSA as an outcome measure in prostate cancer clinical trials
    • Fleming MT, Morris MJ, Heller G, Scher HI. Post-therapy changes in PSA as an outcome measure in prostate cancer clinical trials. Nat. Clin. Pract. Oncol. 3(12), 658-667 (2006).
    • (2006) Nat. Clin. Pract. Oncol , vol.3 , Issue.12 , pp. 658-667
    • Fleming, M.T.1    Morris, M.J.2    Heller, G.3    Scher, H.I.4
  • 2
    • 41149166182 scopus 로고    scopus 로고
    • Prostatespecific antigen and prostate cancer: Prediction, detection and monitoring
    • Lilja H, Ulmert D, Vickers AJ. Prostatespecific antigen and prostate cancer: prediction, detection and monitoring. Nat. Rev. Cancer 8(4), 268-278 (2008).
    • (2008) Nat. Rev. Cancer , vol.8 , Issue.4 , pp. 268-278
    • Lilja, H.1    Ulmert, D.2    Vickers, A.J.3
  • 3
    • 0026098581 scopus 로고
    • Gonadotropinreleasing hormone and its analogues
    • Conn PM, Crowley WF Jr. Gonadotropinreleasing hormone and its analogues. N. Engl. J. Med. 324(2), 93-103 (1991).
    • (1991) N. Engl. J. Med , vol.324 , Issue.2 , pp. 93-103
    • Conn, P.M.1    Crowley Jr., W.F.2
  • 4
    • 33645915874 scopus 로고    scopus 로고
    • Comparison of single-agent androgen suppression for advanced prostate cancer
    • Lepor H. Comparison of single-agent androgen suppression for advanced prostate cancer. Rev. Urol. 7(Suppl. 5), S3-S12 (2005).
    • (2005) Rev. Urol , vol.7 , Issue.SUPPL. 5
    • Lepor, H.1
  • 5
    • 29044442028 scopus 로고    scopus 로고
    • Failure to achieve castration levels in patients using leuprolide acetate in locally advanced prostate cancer
    • Yri OE, Bjoro T, Fossa SD. Failure to achieve castration levels in patients using leuprolide acetate in locally advanced prostate cancer. Eur. Urol. 49(1), 54-58 (2006).
    • (2006) Eur. Urol , vol.49 , Issue.1 , pp. 54-58
    • Yri, O.E.1    Bjoro, T.2    Fossa, S.D.3
  • 6
    • 43949144620 scopus 로고    scopus 로고
    • Management of advanced prostate cancer: Can we improve on androgen deprivation therapy?
    • Describes the utility and shortcomings of gonadotrophin-releasing hormone (GnRH) agonist therapy in prostate cancer and highlights the differences in pharmacological profile between GnRH agonists and blockers
    • Anderson J, Abrahamsson PA, Crawford D, Miller K, Tombal B. Management of advanced prostate cancer: can we improve on androgen deprivation therapy? BJU. Int. 101(12), 1497-1501 (2008). Describes the utility and shortcomings of gonadotrophin-releasing hormone (GnRH) agonist therapy in prostate cancer and highlights the differences in pharmacological profile between GnRH agonists and blockers.
    • (2008) BJU. Int , vol.101 , Issue.12 , pp. 1497-1501
    • Anderson, J.1    Abrahamsson, P.A.2    Crawford, D.3    Miller, K.4    Tombal, B.5
  • 7
    • 0022367715 scopus 로고    scopus 로고
    • Waxman J, Man A, Hendry WF et al. Importance of early tumour exacerbation in patients treated with long acting analogues of gonadotrophin releasing hormone for advanced prostatic cancer. Br. Med. J. (Clin. Res. Ed.) 291(6506), 1387-1388 (1985).
    • Waxman J, Man A, Hendry WF et al. Importance of early tumour exacerbation in patients treated with long acting analogues of gonadotrophin releasing hormone for advanced prostatic cancer. Br. Med. J. (Clin. Res. Ed.) 291(6506), 1387-1388 (1985).
  • 8
    • 0022973082 scopus 로고
    • Cyproterone acetate lead-in prevents initial rise of serum testosterone induced by luteinizing hormone-releasing hormone analogs in the treatment of metastatic carcinoma of the prostate
    • Boccon-Gibod L, Laudat MH, Dugue MA, Steg A. Cyproterone acetate lead-in prevents initial rise of serum testosterone induced by luteinizing hormone-releasing hormone analogs in the treatment of metastatic carcinoma of the prostate. Eur. Urol. 12(6), 400-402 (1986).
    • (1986) Eur. Urol , vol.12 , Issue.6 , pp. 400-402
    • Boccon-Gibod, L.1    Laudat, M.H.2    Dugue, M.A.3    Steg, A.4
  • 9
    • 0025688334 scopus 로고
    • Sudden death due to disease flare with luteinizing hormone-releasing hormone agonist therapy for carcinoma of the prostate
    • Thompson IM, Zeidman EJ, Rodriguez FR. Sudden death due to disease flare with luteinizing hormone-releasing hormone agonist therapy for carcinoma of the prostate. J. Urol. 144(6), 1479-1480 (1990).
    • (1990) J. Urol , vol.144 , Issue.6 , pp. 1479-1480
    • Thompson, I.M.1    Zeidman, E.J.2    Rodriguez, F.R.3
  • 10
    • 44649169622 scopus 로고    scopus 로고
    • Testosterone surge: Rationale for gonadotropin-releasing hormone blockers?
    • Describes the GnRH agonist-induced testosterone surge and its clinical consequences, and highlights the differences in pharmacological profile between GnRH agonists and blockers
    • Van Poppel H, Nilsson S. Testosterone surge: rationale for gonadotropin-releasing hormone blockers? Urology 71(6), 1001-1006 (2008). Describes the GnRH agonist-induced testosterone surge and its clinical consequences, and highlights the differences in pharmacological profile between GnRH agonists and blockers.
    • (2008) Urology , vol.71 , Issue.6 , pp. 1001-1006
    • Van Poppel, H.1    Nilsson, S.2
  • 12
    • 53249121469 scopus 로고    scopus 로고
    • Gittelman M, Pommerville PJ, Persson BE, Jensen JK, Olesen TK. A 1-year, open label, randomized Phase II dose finding study of degarelix for the treatment of prostate cancer in North America. J. Urol. 180(5), 1986-1992 (2008). Together with the study in [13], this study identified the degarelix dose regimens to be tested in the Phase III trial and demonstrated that 1-year degarelix treatment resulted in a fast, profound and sustained suppression of testosterone and prostate-specific antigen (PSA) with no evidence of testosterone surge.
    • Gittelman M, Pommerville PJ, Persson BE, Jensen JK, Olesen TK. A 1-year, open label, randomized Phase II dose finding study of degarelix for the treatment of prostate cancer in North America. J. Urol. 180(5), 1986-1992 (2008). Together with the study in [13], this study identified the degarelix dose regimens to be tested in the Phase III trial and demonstrated that 1-year degarelix treatment resulted in a fast, profound and sustained suppression of testosterone and prostate-specific antigen (PSA) with no evidence of testosterone surge.
  • 13
    • 50849110501 scopus 로고    scopus 로고
    • Van Poppel H, Tombal B, de la Rosette JJ, Persson BE, Jensen JK, Kold OT. Degarelix: a novel gonadotropin-releasing hormone (GnRH) receptor blocker-results from a 1-yr, multicentre, randomised, Phase 2 dosage-finding study in the treatment of prostate cancer. Eur. Urol. 54(4), 805-813 (2008). Together with the study in [12], this study identified the degarelix dose regimens to be tested in the Phase III trial and demonstrated that 1-year degarelix treatment resulted in a fast, profound and sustained suppression of testosterone and PSA with no evidence of testosterone surge.
    • Van Poppel H, Tombal B, de la Rosette JJ, Persson BE, Jensen JK, Kold OT. Degarelix: a novel gonadotropin-releasing hormone (GnRH) receptor blocker-results from a 1-yr, multicentre, randomised, Phase 2 dosage-finding study in the treatment of prostate cancer. Eur. Urol. 54(4), 805-813 (2008). Together with the study in [12], this study identified the degarelix dose regimens to be tested in the Phase III trial and demonstrated that 1-year degarelix treatment resulted in a fast, profound and sustained suppression of testosterone and PSA with no evidence of testosterone surge.
  • 14
    • 56649116179 scopus 로고    scopus 로고
    • Klotz L, Boccon-Gibod L, Shore ND et al. The efficacy and safety of degarelix: a 12-month, comparative, randomized, open-label, parallel-group Phase III study in patients with prostate cancer. BJU Int. 102(11), 1531-1538 (2008). Demonstrates that degarelix is as effective as leuprolide over 1-year prostate cancer treatment in terms of inducing and maintaining testosterone suppression and that it achieves a more rapid suppression of testosterone and PSA than leuprolide, without testosterone surge.
    • Klotz L, Boccon-Gibod L, Shore ND et al. The efficacy and safety of degarelix: a 12-month, comparative, randomized, open-label, parallel-group Phase III study in patients with prostate cancer. BJU Int. 102(11), 1531-1538 (2008). Demonstrates that degarelix is as effective as leuprolide over 1-year prostate cancer treatment in terms of inducing and maintaining testosterone suppression and that it achieves a more rapid suppression of testosterone and PSA than leuprolide, without testosterone surge.
  • 15
    • 70350257619 scopus 로고    scopus 로고
    • Degarelix: A new approach for the treatment of prostate cancer
    • Persson BE, Kold Olesen T, Jensen JK. Degarelix: a new approach for the treatment of prostate cancer. Neuroendocrinology. 90(3), 235-244 (2009).
    • (2009) Neuroendocrinology , vol.90 , Issue.3 , pp. 235-244
    • Persson, B.E.1    Kold Olesen, T.2    Jensen, J.K.3
  • 16
    • 0023859321 scopus 로고
    • Clinical utility of prostatic specific antigen and prostatic acid phosphatase serum levels in monitoring prostate cancer
    • Morote J, Ruibal A, Palou J, de Torres JA, Soler-Rosello A. Clinical utility of prostatic specific antigen and prostatic acid phosphatase serum levels in monitoring prostate cancer. Int. J. Biol. Markers 3(1), 23-28 (1988).
    • (1988) Int. J. Biol. Markers , vol.3 , Issue.1 , pp. 23-28
    • Morote, J.1    Ruibal, A.2    Palou, J.3    de Torres, J.A.4    Soler-Rosello, A.5
  • 17
    • 0024538468 scopus 로고
    • Changes in prostate-specific markers under chronic gonadotrophinreleasing hormone analogue treatment of state D prostatic cancer
    • Matzkin H, Lewyshon O, Ayalon D, Braf Z. Changes in prostate-specific markers under chronic gonadotrophinreleasing hormone analogue treatment of state D prostatic cancer. Cancer 63(7), 1287-1291 (1989).
    • (1989) Cancer , vol.63 , Issue.7 , pp. 1287-1291
    • Matzkin, H.1    Lewyshon, O.2    Ayalon, D.3    Braf, Z.4
  • 18
    • 0029077920 scopus 로고
    • Prostate specific antigen levels and clinical response to low dose dexamethasone for hormone-refractory metastatic prostate carcinoma
    • Storlie JA, Buckner JC, Wiseman GA, Burch PA, Hartmann LC, Richardson RL. Prostate specific antigen levels and clinical response to low dose dexamethasone for hormone-refractory metastatic prostate carcinoma. Cancer 76(1), 96-100 (1995).
    • (1995) Cancer , vol.76 , Issue.1 , pp. 96-100
    • Storlie, J.A.1    Buckner, J.C.2    Wiseman, G.A.3    Burch, P.A.4    Hartmann, L.C.5    Richardson, R.L.6
  • 19
    • 0031832733 scopus 로고    scopus 로고
    • Smith DC, Dunn RL, Strawderman MS, Pienta KJ. Change in serum prostatespecific antigen as a marker of response to cytotoxic therapy for hormone-refractory prostate cancer. J. Clin. Oncol. 16(5), 1835-1843 (1998).
    • Smith DC, Dunn RL, Strawderman MS, Pienta KJ. Change in serum prostatespecific antigen as a marker of response to cytotoxic therapy for hormone-refractory prostate cancer. J. Clin. Oncol. 16(5), 1835-1843 (1998).
  • 20
    • 34548400276 scopus 로고    scopus 로고
    • Morote J, Orsola A, Planas J et al. Redefining clinically significant castration levels in patients with prostate cancer receiving continuous androgen deprivation therapy. J. Urol. 178(4 Pt 1), 1290-1295 (2007). Shows that breakthrough increases in plasma testosterone (>32 ng/ml) during GnRH agonist therapy predict reduced survival free of androgen-independent progression. Concomitant antiandrogen treatment provided a significantly longer survival free of androgen-independent progression in those with breakthrough increases greater than 50 ng/dl.
    • Morote J, Orsola A, Planas J et al. Redefining clinically significant castration levels in patients with prostate cancer receiving continuous androgen deprivation therapy. J. Urol. 178(4 Pt 1), 1290-1295 (2007). Shows that breakthrough increases in plasma testosterone (>32 ng/ml) during GnRH agonist therapy predict reduced survival free of androgen-independent progression. Concomitant antiandrogen treatment provided a significantly longer survival free of androgen-independent progression in those with breakthrough increases greater than 50 ng/dl.
  • 21
    • 54949104374 scopus 로고    scopus 로고
    • Roles of the urologist and nurse from the perspective of patients with prostate cancer receiving luteinizing hormone-releasing hormone analogue therapy
    • Lebret T, Bouregba A. Roles of the urologist and nurse from the perspective of patients with prostate cancer receiving luteinizing hormone-releasing hormone analogue therapy. BJU Int. 102(10), 1419-1424 (2008).
    • (2008) BJU Int , vol.102 , Issue.10 , pp. 1419-1424
    • Lebret, T.1    Bouregba, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.