Successful treatment of multicentric reticulohistiocytosis with leflunomide

British Journal of Dermatology

Volumn 161, Issue 2, 2009, Pages 470-472

  Lonsdale Eccles, A A ^a   Haworth, A E ^a   McCrae, F C ^b   Young Min, S A ^b  

^a ST MARY S HOSPITAL   (United Kingdom)

^b QUEEN ALEXANDRA HOSPITAL   (United Kingdom)

Author keywords

Leflunomide; Multicentric reticulohistiocytosis; Non Langerhans histiocytosis

Indexed keywords

IMMUNOSUPPRESSIVE AGENT; ISOXAZOLE DERIVATIVE; LEFLUNOMIDE; PREDNISOLONE;

AGED; CASE REPORT; HISTIOCYTOSIS; HUMAN; LETTER; MALE; PATHOLOGY; TREATMENT OUTCOME;

AGED; HISTIOCYTOSIS, NON-LANGERHANS-CELL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; ISOXAZOLES; MALE; PREDNISOLONE; TREATMENT OUTCOME;

EID: 73349111929     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2009.09227.x     Document Type: Letter

References (7)

1. Hsiung SH, Chan EF, Elenitsas R et al. Multicentric reticulohistiocytosis presenting with clinical features of dermatomyositis. J Am Acad Dermatol 2003; 48: S11-14.
2. Tait TJ, Bird HA, Ford GP. Multicentric reticulohistiocytosis: presentation with the cutaneous features of dermatomyositis. Br J Rheumatol 1994; 33: 100-1.
3. Breedveld FC, Dayer JM. Leflunomide: mode of action in the treatment of rheumatoid arthritis. Ann Rheum Dis 2000; 59: 841-9.
4. Manna SK, Aggarwal BB. Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression. J Immunol 1999; 162: 2095-102.
5. Nakamura H, Yoshino S, Shiga H et al. A case of spontaneous femoral neck fracture associated with multicentric reticulohistiocytosis: oversecretion of interleukin-1beta, interleukin-6, and tumor necrosis factor alpha by affected synovial cells. Arthritis Rheum 1997; 40: 2266-70.
6. Shannon SE, Schumacher HR, Self S et al. Multicentric reticulohistiocytosis responding to tumor necrosis factor-alpha inhibition in a renal transplant patient. J Rheumatol 2005; 32: 565-7.
7. Satoh M, Oyama N, Yamada H et al. Treatment trial of multicentric reticulohistiocytosis with a combination of predonisolone, methotrexate and alendronate. J Dermatol 2008; 35: 168-71.