Effects of titanium surface roughness on mesenchymal stem cell commitment and differentiation signaling

International Journal of Oral and Maxillofacial Implants

Volumn 24, Issue 4, 2009, Pages 627-635

  Balloni, Stefania ^a   Calvi, Edoardo Maria ^b   Damiani, Francesco ^b   Bistoni, Giovanni ^c   Calvitti, Mario ^a   Locci, Paola ^a   Becchetti, Ennio ^a   Marinucci, Lorella ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b University La Sapienza ^*  (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Gene expression; Human mesenchymal stem cells; Proliferation; Surface properties; Titanium

Indexed keywords

ALKALINE PHOSPHATASE; BIOMEDICAL AND DENTAL MATERIALS; BMP2 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN 2; BONE SIALOPROTEIN; COLLAGEN; COLLAGEN TYPE 1; DNA; OSTEOCALCIN; OSTEOPONTIN; PROLINE; RUNX2 PROTEIN, HUMAN; SIALOGLYCOPROTEIN; SP7 PROTEIN, HUMAN; THYMIDINE; TITANIUM; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX2;

ADULT; ARTICLE; BIOSYNTHESIS; BONE MARROW CELL; CELL ADHESION; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SHAPE; CHEMISTRY; CYTOLOGY; DENTAL ACID ETCHING; HUMAN; MESENCHYMAL STEM CELL; METABOLISM; METHODOLOGY; MULTIPOTENT STEM CELL; OSTEOBLAST; PHYSIOLOGY; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY;

ACID ETCHING, DENTAL; ADULT; ALKALINE PHOSPHATASE; BONE MARROW CELLS; BONE MORPHOGENETIC PROTEIN 2; CELL ADHESION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SHAPE; CELLS, CULTURED; COLLAGEN; COLLAGEN TYPE I; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DENTAL MATERIALS; DNA; HUMANS; MESENCHYMAL STEM CELLS; MICROSCOPY, ELECTRON, SCANNING; MULTIPOTENT STEM CELLS; OSTEOBLASTS; OSTEOCALCIN; OSTEOPONTIN; PROLINE; SIALOGLYCOPROTEINS; SURFACE PROPERTIES; THYMIDINE; TITANIUM; TRANSCRIPTION FACTORS;

EID: 73349110130     PISSN: 08822786     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Caplan AI, Dennis JE. Mesenchymal stem cells: Progenitors, progeny and pathway. J Bone Miner Res 1996;14:193-201.
2. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-147.
3. Frank O, Heim M, Jakob M, et al. Real-time quantitative RT-PCR analysis of human bone marrow stromal cells during osteogenic differentiation in vitro. J Cell Biochem 2002;85:737-746.
4. Weissman IL, Anderson GJ, Gage F. Stem and progenitor cells:Origins, phenotype, lineage commitments and transdifferentiations. Annu Rev Cell Dev Biol 2001;17:387-403.
5. Park EK, Lee YE, Choi J, et al. Cellular biocompatibility and stimulatory effects of calcium metaphosphate on osteoblastic differentiation of human bone marrow-derived stromal cells. Biomaterials 2004;25:3403-3411.
6. Banerjee C, Javed A, Choi JY, et al. Differential regulation of the two principal Runx2/Cbfa1 N-terminal isoforms in response to bone morphogenetic protein-2 during development of the osteoblast phenotype. Endocrinology 2001;142:4026-4039.
7. Shui C, Spelsberg TC, Riggs BL, Khosla S. Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stromal cells. J Bone Miner Res 2003;18:213-221.
8. Komori T. Requisite roles of Runx2 and Cbfb in skeletal development. J Bone Miner Metab 2003;21:193-197.
9. Nakashima K, Zhou X, Kunkel G, et al. The novel zing fingercontaining transcription factor Osterix is required for osteoblast differentiation and bone formation. Cell 2002;108:17-29.
10. Tai G, Polak JM, Bishop AE, Christodoulou I, Buttery LDK. Differentiation of osteoblasts from murine embryonic stem cells by overexpression of the transcription factor osterix. Tissue Eng 2004;10:1456-1466.
11. Kanno T, Takahashi T, Tsujisawa T, Ariyoshi W, Nishihara T. Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts. J Cell Biol 2007;101:1266-1277.
12. Schneider GB, Perinpanayagam H, Clegg M, et al. Implant surface roughness affects osteoblast gene expression. J Dent Res 2003;82:372-376.
13. Zinger O, Zhao G, Schwartz Z, et al. Differential regulation of osteoblasts by substrate microstructural features. Biomaterials 2005;26:1837-1847.
14. Veis AA, Trisi P, Papadimitriou S, et al. Osseointegration of AE and machined titanium implants in autogenous bone graft. A histologic and histomorphometric study in dogs. Clin Oral Implants Res 2004;15:54-61.
15. Li D, Ferguson SJ, Beutler T, et al. Biochemical comparison of the sandblasted and acid-etched and the machined and acid etched titanium surface for dental implants. J Biomed Mater Res 2002;60:325-332.
16. Schwartz Z, Lohmann CH, Sisk M, Cochran DL, Sylvia VL, Simpson J. Local factor production by MG63 osteoblast-like cells in response to surface roughness and 1,25-(OH) 2D3 is mediated via protein kinase C- and protein kinase A-dependent pathways. Biomaterials 2001;22:731-741.
17. Buser D. Titanium for dental applications (II): Implants with roughened surfaces. In: Brunette DM, Tengvall P, Textor M, Thomsen P (eds). Titanium in Medicine. Berlin: Springer, 2001:875-888.
18. Locci P, Becchetti E, Pugliese M, et al. Phenotype expression of human bone cells cultured on implant substrates. Cell Biochem Funct 1997;15:163-170.
19. Webster DF, Harvey W. A quantitative assay for collagen synthesis in microwell fibroblast cultures. Anal Biochem 1979; 96:220-224.
20. Ibbotson KJ, Harrod J, Gowen M, et al. Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro. Proc Natl Acad Sci USA 1986;83:2228-2232.
21. Lowry OH, Rosebrough NJ, Farr AJ, Randall RJ. Protein measurement with folin phenol reagent. J Biol Chem 1951;193:265-275.
22. Bodo, M, Lilli C, Bellucci C, et al. Basic fibroblast growth factor autocrine loop controls human osteosarcoma phenotyping and differentiation. Mol Med 2002;8:393-404.
23. Cooper LF, Harris CT, Bruder SP, Kowalski R, Kadiyala S. Incipient analysis of mesenchymal stem-cells-derived osteogenesis. J Dent Res 2001;80:314-320.
24. Marinucci L, Balloni S, Becchetti E, et al. Effect of titanium surface roughness on human osteoblast proliferation and gene expression in vitro. Int J Oral Maxillofac Implants 2006;21:719-725.
25. Zhao G, Zinger O, Schwartz Z, Wieland M, Landolt D, Boyan BD. Osteoblast-like cells are sensitive to submicron-scale surface structure. Clin Oral Implants Res 2006;17:258-264.
26. Schneider GB, Zaharias R, Stanford C. Osteoblast integrin adhesion and signaling regulate mineralization. J Dent Res 2001;80:1540-1544.
27. Leboy PS. Regulating bone growth and development with bone morphogenetic proteins. Ann NY Acad Sci 2006;1068:14-18.
28. Yamaguchi A. Regulation of differentiation pathway of skeletal mesenchymal cells in cell lines by transforming growth factor- beta superfamily. Cell Biol 1995;6:165-173.
29. Wozney JM. Engineering new bone with bone morphogenic proteins. Ann Endocrinol 2006;67:180-181.
30. Gilbert L, He X, Farmer P, et al. Expression of the osteoblast differentiation factor Runx2 (Cbfa1/AML3/Pebp2_A) is inhibited by tumor necrosis factor-_. J Biol Chem 2002;277:2695-2701.
31. Zheng H, Guo Z, Ma Q, Jia H, Dang G. Cbfa1/osf2 transduced bone marrow stromal cells facilitate bone formation in vitro and in vivo. Calcif Tissue Int 2004;74:194-203.
32. zur Nieden NI, Kempka G, Ahr HJ. In vitro differentiation of embryonic stem cells into mineralized osteoblasts. Differentiation 2003;71:18-27.
33. Schneider GB, Zaharias R, Seabold D, Keller J, Stanford C. Differentiation of preosteoblasts is affected by implant surface microtopographies. J Biomed Mater Res 2004;69:462-468.