Treatment of anal carcinoma in immune-compromised patients

Clinical and Translational Oncology

Volumn 11, Issue 9, 2009, Pages 609-614

  Barriger, Robert Bryan ^a   Calley, Cindy ^a   Cárdenes, Higinia Rosa ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anal cancer; Chemotherapy; HIV; Outcomes; Radiation; Transplant

Indexed keywords

ADULT; ANUS TUMOR; ARTICLE; CARCINOMA; COLOSTOMY; DISEASE COURSE; EVALUATION; FEMALE; FOLLOW UP; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOCOMPROMISED PATIENT; IMMUNOLOGY; MALE; MIDDLE AGED; MORTALITY; REGISTER; SALVAGE THERAPY; STATISTICS; SURVIVAL; TRANSPLANTATION;

ADULT; ANUS NEOPLASMS; CARCINOMA; COLOSTOMY; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HIV SEROPOSITIVITY; HIV-1; HUMANS; IMMUNOCOMPROMISED HOST; MALE; MIDDLE AGED; REGISTRIES; SALVAGE THERAPY; SURVIVAL ANALYSIS; TRANSPLANTATION;

EID: 73349104135     PISSN: 1699048X     EISSN: 16993055     Source Type: Journal    
DOI: 10.1007/s12094-009-0412-0     Document Type: Article

References (18)

1. Busnach G, Piselli P, Arbustini E et al (2006) Immunosuppression and cancer: A comparison of risks in recipients of organ transplants and in HIV-positive individuals. Transplant Proc 38:3533-3535
2. Melbye M, Cote TR, Kessler L et al (1994) High incidence of anal cancer among AIDS patients. The AIDS/Cancer Working Group. Lancet 343:636-639
3. Penn I (1986) Cancers of the anogenital region in renal transplant recipients. Analysis of 65 cases. Cancer 58:611-616
4. Fairley CK, Sheil AG, McNeil JJ et al (1994) The risk of ano-genital malignancies in dialysis and transplant patients. Clin Nephrol 41:101-105
5. Aigner F, Boeckle E, Albright J et al (2007) Malignancies of the colorectum and anus in solid organ recipients. Transpl Int 20:497-504
6. Holland JM, Swift PS (1994) Tolerance of patients with human immunodeficiency virus and anal carcinoma to treatment with combined chemotherapy and radiation therapy. Radiology 193:251-254
7. Kim JH, Sarani B, Orkin BA et al (2001) HIVpositive patients with anal carcinoma have poorer treatment tolerance and outcome than HIV-negative patients. Dis Colon Rectum 44:1496-1502
8. Hoffman R, Welton ML, Klencke B et al (1999) The significance of pretreatment CD4 count on the outcome and treatment tolerance of HIV-positive patients with anal cancer. Int J Radiat Oncol Biol Phys 44:127-131
9. Radiation Therapy Oncology Group (2008) Acute Radiation Morbidity Scoring Criteria. RTOG. http://www.rtog.org/members/toxicity/acute.html
10. Radiation Therapy Oncology Group (2008) European Organization for Research and Treatment of Cancer. RTOG/EORTC Late radiation morbidity scoring schema. RTOG. http://www.rtog.org/members/toxicity/late.html
11. Blazy A, Hennequin C, Gornet J-M et al (2005) Anal carcinomas in HIV-positive patients: Highdose chemoradiotherapy is feasible in the era of highly active antiretroviral therapy. Dis Colon Rectum 48:1176-1181
12. Chadha M, Rosenblatt EA, Malamud S et al (1994) Squamous-cell carcinoma of the anus in HIV-positive patients. Dis Colon Rectum 37:861-865
13. Cleator S, Fife K, Nelson M et al (2000) Treatment of HIV-associated invasive anal cancer with combined chemoradiation. Eur J Cancer 36:754-758
14. Edelman S, Johnstone PAS (2006) Combined modality therapy for HIV-infected patients with squamous cell carcinoma of the anus: Outcomes and toxicities. Int J Radiat Oncol Biol Phys 66:206-211
15. Peddada AV, Smith DE, Rao AR et al (1997) Chemotherapy and low-dose radiotherapy in the treatment of HIV-infected patients with carcinoma of the anal canal. Int J Radiat Oncol Biol Phys 37:1101-1105
16. Ajani JA, Winter KA, Gunderson LL et al (2008) Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: A randomized controlled trial. JAMA 299:1914-1921
17. Bartelink H, Roelofsen F, Eschwege F et al (1997) Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: Results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. J Clin Oncol 15:2040-2049
18. Place RJ, Gregorcyk SG, Huber PJ, Simmang CL (2001) Outcome analysis of HIV-positive patients with anal squamous cell carcinoma. Dis Colon Rectum 44:506-512