Inhibition of vascular endothelial growth factor receptor-1/Wnt/ β-catenin crosstalk leads to tumor cell death

Clinical Cancer Research

Volumn 15, Issue 24, 2009, Pages 7453-7455

  Zeitlin, Benjamin D ^a   Ellis, Lee M ^c   Nör, Jacques E ^a,b  

^a School of Dentistry   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; PROTEIN TYROSINE KINASE INHIBITOR; SHORT HAIRPIN RNA; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; WNT PROTEIN;

ANGIOGENESIS; ARTICLE; BIOAVAILABILITY; CANCER CELL; CELL DEATH; CELL POLARITY; CELL PROLIFERATION; COLORECTAL CANCER; ENZYME ACTIVITY; GENE SILENCING; HUMAN; MICROENVIRONMENT; ONCOGENE C MYC; PRIORITY JOURNAL; RNA INTERFERENCE; SCREENING; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 73349101477     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-09-2578     Document Type: Article

References (13)

1. Naik S, Dothager RS, Marasa J, Lewis CL, Piwnica-Worms D. Vascular endothelial growth factor receptor-1 is synthetic lethal to aberrant β-catenin activation in colon cancer. Clin Cancer Res 2009;15:7529-37.
2. MacDonald BT, Tamai K, He X. Wnt/β-catenin signaling: Components, mechanisms, and diseases. Dev Cell 2009;17:9-26.
3. Huang D, Du X. Crosstalk between tumor cells and microenvironment via wnt pathway in colorectal cancer dissemination. World J Gastroenterol 2008;14:1823-7.
4. Luo J, Emanuele MJ, Li D, et al. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the ras oncogene. Cell 2009; 137:835-48.
5. Scholl C, Frohling S, Dunn IF, et al. Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell 2009;137:821-34.
6. Roskoski R, Jr. Vascular endothelial growth factor (VEGF) signaling in tumor progression. Crit Rev Oncol Hematol 2007;62:179-213.
7. Zhang Z, Neiva K, Lingen MW, Ellis LM, Nör JE. VEGF-dependent tumor angiogenesis requires the inverse and reciprocal regulation of VEGFR1 and VEGFR2. Cell Death Differ. Epub 2009 Oct 16.
8. Mittar S, Ulyatt C, Howell GJ, et al. VEGFR1 receptor tyrosine kinase localization to the golgi apparatus is calcium-dependent. Exp Cell Res 2009;315:877-89.
9. Fan F, Wey JS, McCarty MF, et al. Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. Oncogene 2005;24:2647-53.
10. Zhang X, Gaspard JP, Chung DC. Regulation of vascular endothelial growth factor by the wnt and K-ras pathways in colonic neoplasia. Cancer Res 2001;61:6050-4.
11. Ellis LM, Hicklin DJ. VEGF-targeted therapy: Mechanisms of anti-tumour activity. Nat Rev Cancer 2008;8:579-91.
12. Kleinman ME, Yamada K, Takeda A, et al. Sequence-and target-independent angiogenesis suppression by siRNA via TLR3. Nature 2008; 452:591-7.
13. Weihua Z, Tsan R, Huang WC, et al. Survival of cancer cells is maintained by EGFR independent of its kinase activity. Cancer Cell 2008;13: 385-93.