Staining patterns of keratins in the human urinary tract

Histology and Histopathology

Volumn 24, Issue 11, 2009, Pages 1425-1437

  Alonso, Angelika ^a   Ikinger, Uwe ^b   Kartenbeck, Jürgen ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b Krankenhaus Salem   (Germany)

Author keywords

Keratins; Umbrella cells; Urinary bladder; Urothelium

Indexed keywords

KERATIN;

ADULT; ARTICLE; BIOSYNTHESIS; FLUORESCENT ANTIBODY TECHNIQUE; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; PRENATAL DEVELOPMENT; STAINING; TRANSMISSION ELECTRON MICROSCOPY; URINARY TRACT; UROTHELIUM;

ADULT; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; KERATINS; MICROSCOPY, ELECTRON, TRANSMISSION; STAINING AND LABELING; URINARY TRACT; UROTHELIUM;

EID: 73349097897     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Acharya P., Beckel J., Ruiz W.G., Wang E., Rojas R., Birder L. and Apodaca G. (2004). Distribution of the tight junction proteins ZO-1, occludin, and claudin-4,-8, and-12 in bladder epithelium. Am. J. Physiol. Renal Physiol. 287, F305-F318.
2. Achtstatter T., Moll R., Moore B. and Franke W.W. (1985). Cytokeratin polypeptide patterns of different epithelia of the human male urogenital tract: immunofluorescence and gel electrophoretic studies. J. Histochem. Cytochem. 33, 415-426.
3. Amano O., Kataoka S. and Yamamoto T.Y. (1988). Derivation and termination of fusiform vesicles in the transitional epithelium of the rat urinary bladder. Tohoku J. Exp. Med. 156, 417-418.
4. Amano O., Kataoka S. and Yamamoto T.Y. (1991). Turnover of asymmetric unit membranes in the transitional epithelial superficial cells of the rat urinary bladder. Anat. Rec. 229, 9-15.
5. Apodaca G. (2004). The uroepithelium: not just a passive barrier. Traffic 5, 117-128.
6. Bulger R.E. (1988). Epithelium, The urinary system. In: Cell and tissue biology, A textbook of histology. 6th ed. Chapter 4. Weiss L. (ed). Urban & Schwarzenberg. Baltimore, Munich. pp 817-850.
7. Chu P.G. and Weiss L.M. (2002). Keratin expression in human tissues and neoplasms. Histopathology 40, 403-439.
8. Cooper D., Schermer A. and Sun T.T. (1985). Classification of human epithelia and their neoplasms using monoclonal antibodies to keratins: strategies, applications, and limitations. Lab. Invest. 52, 243-256.
9. de la Rosette J., Smedts F., Schoots C., Hoek H. and Laguna P. (2002). Changing patterns of keratin expression could be associated with functional maturation of the developing human bladder. J. Urol. 168, 709-717.
10. Debus E., Weber K. and Osborn M. (1982). Monoclonal cytokeratin antibodies that distinguish simple from stratified squamous epithelia: characterization on human tissues. EMBO J. 1, 1641-1647.
11. Franke W.W., Schiller D.L., Moll R., Winter S., Schmid E., Engelbrecht I., Denk H., Krepler R. and Platzer B. (1981). Diversity of cytokeratins. Differentiation specific expression of cytokeratin polypeptides in epithelial cells and tissues. J. Mol. Biol. 153, 933-959.
12. Franke W.W., Schmid E., Freudenstein C., Appelhans B., Osborn M., Weber K. and Keenan T.W. (1980). Intermediate-sized filaments of the prekeratin type in myoepithelial cells. J. Cell Biol. 84, 633-654.
13. Grimm S.L., Bu W., Longley M.A., Roop D.R., Li Y. and Rosen J.M. (2006). Keratin 6 is not essential for mammary gland development. Breast Cancer Res. 8, R29.
14. Herrmann H. and Aebi U. (2004). Intermediate filaments: molecular structure, assembly mechanism, and integration into functionally distinct intracellular Scaffolds. Annu. Rev. Biochem. 73, 749-789.
15. Hicks R.M. (1975). The mammalian urinary bladder: an accommodating organ. Biol. Rev. 50, 215-246.
16. Hu P., Deng F.M., Liang F.X., Hu C.M., Auerbach A., Shapiro E., Wu X.R., Kachar B. and Sun T.T. (2001). Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux. Urology 57 (6 Suppl. 1), 117.
17. Hu P., Meyers S., Liang F.X., Deng F.M., Kachar B., Zeidel M.L. and Sun T.T. (2002). Role of membrane proteins in permeability barrier function: uroplakin ablation elevates urothelial permeability. Am. J. Physiol. Renal Physiol. 283, F1200-F1207.
18. Jost S.P., Gosling J.A. and Dixon J.S. (1989). The morphology of normal human bladder urothelium. J. Anat. 167, 103-115.
19. Kamada M., Kobayashi T., Nahirney P.C., Okada T., delSaz E.G., Shuin T. and Seguchi H. (1997). Actin and cytokeratin in superficial transitional epithelial cells of the rabbit urinary bladder: A confocal and electron microscopic study. Acta Histochem. Cytochem. 30, 29-36.
20. Kartenbeck J., Stukenbrok H. and Helenius A. (1989). Endocytosis of simian virus 40 into the endoplasmic reticulum. J. Cell Biol. 109, 2721-2729.
21. Kim S., Wong P. and Coulombe P.A. (2006). A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Nature 441, 362-365.
22. Komine M., Rao L.S., Freedberg I.M., Simon M., Milisavljevic V. and Blumenberg M. (2001). Interleukin-1 induces transcription of keratin K6 in human epidermal keratinocytes. J. Invest. Dermatol. 116, 330-338.
23. Kunju L.P., Lee C.T., Montie J. and Shah R.B. (2005). Utility of cytokeratin 20 and Ki-67 as markers of urothelial dysplasia. Pathol. Int. 55, 248-254.
24. Kurzrock E.A., Lieu D.K., Degraffenried L.A., Chan C.W. and Isseroff R.R. (2008). Label-retaining cells of the bladder: candidate urothelial stem cells. Am. J. Physiol. Renal Physiol. 294, F1415-F1421.
25. Laguna P., Smedts F., Nordling J., Horn T., Bouchelouche K., Hopman A. and de la Rosette J. (2006). Keratin expression profiling of transitional epithelium in the painful bladder syndrome/interstitial cystitis. Am. J. Clin. Pathol. 125, 105-110.
26. Langbein L., Grund C., Kuhn C., Praetzel S., Kartenbeck J., Brandner J.M., Moll I. and Franke W.W. (2002a). Tight junctions and compositionally related junctional structures in mammalian stratified epithelia and cell cultures derived therefrom. Eur. J. Cell Biol. 81, 419-435.
27. Langbein L., Rogers M.A., Praetzel S., Aoki N., Winter H. and Schweizer J. (2002b). A novel epithelial keratin, hK6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Flugelzellen) of the human hair follicle. J. Invest. Dermatol. 118, 789-799.
28. Langbein L., Rogers M.A., Praetzel S., Cribier B., Peltre B., Gassler N. and Schweizer J. (2005). Characterization of a novel human type II epithelial keratin K1b, specifically expressed in eccrine sweat glands. J. Invest Dermatol. 125, 428-444.
29. Mallofre C., Castillo M., Morente V. and Sole M. (2003). Immunohistochemical expression of CK20, p53, and Ki-67 as objective markers of urothelial dysplasia. Mod. Pathol. 16, 187-191.
30. Moll R. (1986). Epithelial tumor markers. Verh. Dtsch. Ges. Pathol. 70, 28-50 (In German).
31. Moll R. (1993). Cytokeratins as markers of differentiation. Expression profiles in epithelia and epithelial tumors. Veroff. Pathol. 142, 1-197 (In German).
32. Moll R., Franke W.W., Schiller D.L., Geiger B. and Krepler R. (1982). The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 31, 11-24.
33. Moll R., Krepler R. and Franke W.W. (1983). Complex cytokeratin polypeptide patterns observed in certain human carcinomas.
34. Moll R., Achtstatter T., Becht E., Balcarova-Stander J., Ittensohn M. and Franke W.W. (1988). Cytokeratins in normal and malignant transitional epithelium. Maintenance of expression of urothelial differentiation features in transitional cell carcinomas and bladder carcinoma cell culture lines. Am. J. Pathol. 132, 123-144.
35. Moll R., Schiller D.L. and Franke W.W. (1990). Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns. J. Cell Biol. 111, 567-580.
36. Moll R., Divo M. and Langbein L. (2008). The human keratins: biology and pathology. Histochem. Cell Biol. 129, 705-733.
37. Moll R., Divo M. and Langbein L. (2008). Differentiation 23, 256-269.
38. Mommers J.M., van Rossum M.M., van Erp P.E. and van De Kerkhof P.C. (2000). Changes in keratin 6 and keratin 10 (co-)expression in lesional and symptomless skin of spreading psoriasis. Dermatology 201, 15-20.
39. Petry G. and Amon H. (1966). Light and electron microscopic studies on the structure and dynamics of transitional epithelium. Z. Zellforsch. Mikrosk. Anat. 69, 587-612 (In German).
40. Retz M., Lehmann J., Amann E., Wullich B., Roder C. and Stockle M. (2003). Mucin 7 and cytokeratin 20 as new diagnostic urinary markers for bladder tumor. J. Urol. 169, 86-89.
41. Riedel I., Liang F.X., Deng F.M., Tu L., Kreibich G., Wu X.R., Sun T.T., Hergt M. and Moll R. (2005). Urothelial umbrella cells of human ureter are heterogeneous with respect to their uroplakin composition: different degrees of urothelial maturity in ureter and bladder? Eur. J. Cell Biol. 84, 393-405.
42. Romih R., Veranic P. and Jezernik K. (1999). Actin filaments during terminal differentiation of urothelial cells in the rat urinary bladder. Histochem. Cell Biol. 112, 375-380.
43. Romih R., Veranic P. and Jezernik K. (2002). Appraisal of differentiation markers in urothelial cells. Appl. Immunohistochem. Mol. Morphol. 10, 339-343.
44. Romih R., Korosec P., de Mello W. Jr and Jezernik K. (2005). Differentiation of epithelial cells in the urinary tract. Cell Tissue Res. 320, 259-268.
45. Rothnagel J.A., Seki T., Ogo M., Longley M.A., Wojcik S.M., Bundman D.S., Bickenbach J.R. and Roop D.R. (1999). The mouse keratin 6 isoforms are differentially expressed in the hair follicle, footpad, tongue and activated epidermis. Differentiation 65, 119-130.
46. Schaafsma H.E., Ramaekers F.C., van Muijen G.N., Ooms E.C. and Ruiter D.J. (1989). Distribution of cytokeratin polypeptides in epithelia of the adult human urinary tract. Histochemistry 91, 151-159.
47. Smedts F., Ramaekers F., Leube R.E., Keijser K., Link M. and Vooijs P. (1993). Expression of keratins 1, 6, 15, 16, and 20 in normal cervical epithelium, squamous metaplasia, cervical intraepithelial neoplasia, and cervical carcinoma. Am. J. Pathol. 142, 403-412.
48. Somji S., Bathula C.S., Zhou X.D., Sens M.A., Sens D.A. and Garrett S.H. (2008). Transformation of Human Urothelial Cells (UROtsa) by As and Cd Induces the Expression of Keratin 6a. Environ. Health Perspect. 116, 434-440.
49. Southgate J. and Harnden P. (1999). Re: Cytokeratin 20: a new marker for early detection of bladder cell carcinoma. J. Urol. 162, 501-502.
50. Sun T.T. (2006). Altered phenotype of cultured urothelial and other stratified epithelial cells: implications for wound healing. Am. J. Physiol. Renal Physiol. 291, F9-21.
51. Teutsch H.F. (1977). Crusta in the transitional epithelium. Verh. Anat. Ges. 1223-1226 (In German).
52. Troyanovsky S.M., Guelstein V.I., Tchipysheva T.A., Krutovskikh V.A. and Bannikov G.A. (1989). Patterns of expression of keratin 17 in human epithelia: dependency on cell position. J. Cell Sci. 93 (Pt 3), 419-426.
53. Truschel S.T., Wang E., Ruiz W.G., Leung S.M., Rojas R., Lavelle J., Zeidel M., Stoffer D. and Apodaca G. (2002). Stretch-regulated exocytosis/endocytosis in bladder umbrella cells. Mol. Biol. Cell 13, 830-846.
54. Vaidyanathan S., McDicken I.W., Ikin A.J., Mansour P., Soni B.M., Singh G. and Sett P. (2002). A study of cytokeratin 20 immunostaining in the urothelium of neuropathic bladder of patients with spinal cord injury. BMC Urol. 2, 7
55. van Muijen G.N., Ruiter D.J., Franke W.W., Achtstatter T., Haasnoot W.H., Ponec M. and Warnaar S.O. (1986). Cell type heterogeneity of cytokeratin expression in complex epithelia and carcinomas as demonstrated by monoclonal antibodies specific for cytokeratins nos. 4 and 13. Exp. Cell Res. 162, 97-113.
56. Veranic P. and Jezernik K. (2002). Trajectorial organisation of cytokeratins within the subapical region of umbrella cells. Cell Motil. Cytoskeleton 53, 317-325.
57. Veranic P., Romih R. and Jezernik K. (2004). What determines differentiation of urothelial umbrella cells? Eur. J. Cell Biol. 83, 27-34.
58. Wong P. and Coulombe P.A. (2003). Loss of keratin 6 (K6) proteins reveals a function for intermediate filaments during wound repair. J. Cell Biol. 163, 327-337.
59. Wu X.R., Lin J.H., Walz T., Haner M., Yu J., Aebi U. and Sun T.T. (1994). Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins. J. Biol. Chem. 269, 13716-13724.