Analysis of characteristics of mononuclear cells remaining in the leukoreduction system chamber of Trima Accel® and their differentiation into dendritic cells

Korean Journal of Laboratory Medicine

Volumn 29, Issue 4, 2009, Pages 353-360

  Lee, Yangsoon ^a   Kim, Sinyoung ^a   Lee, Seung Tae ^a   Kim, Han Soo ^b   Baek, Eun Jung ^a   Kim, Hyung Jin ^b   Lee, MeeKyung ^c   Kim, Hyun Ok ^a,b  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei Cell Therapy Center   (South Korea)

^c Korean Red Cross   (South Korea)

Author keywords

Dendritic cell; Leukoreduction chamber; Trima Accel

Indexed keywords

ADULT; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CYTOLOGY; DENDRITIC CELL; FLOW CYTOMETRY; HUMAN; IMMUNOLOGY; INSTRUMENTATION; NATURAL KILLER CELL; THROMBOCYTOPHERESIS;

ADULT; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; DENDRITIC CELLS; FLOW CYTOMETRY; HUMANS; KILLER CELLS, NATURAL; PLATELETPHERESIS;

EID: 73349095044     PISSN: 15986535     EISSN: None     Source Type: Journal    
DOI: 10.3343/kjlm.2009.29.4.353     Document Type: Article

References (15)

1. Shehata N, Lin Y, Pendergrast J, Branch DR. Cellular therapies: a Canadian blood services research and development symposium. Transfus Med Rev 2007;21:317-36.
2. Mellman I and Steinman RM. Dendritic cells: specialized and regulated antigen processing machines. Cell 2001;106:255-8.
3. Sniecinski I, O'Donnell MR, Nowicki B, Hill LR. Prevention of refractoriness and HLA-alloimmunization using filtered blood products. Blood 1988;71:1402-7.
4. Meyer TP, Zehnter I, Hofmann B, Zaisserer J, Burkhart J, Rapp S, et al. Filter Buffy Coats (FBC): a source of peripheral blood leukocytes recovered from leukocyte depletion filters. J Immunol Methods 2005; 307:150-66.
5. Ebner S, Neyer S, Hofer S, Nussbaumer W, Romani N, Heufler C. Generation of large numbers of human dendritic cells from whole blood passaged through leukocyte removal filters: an alternative to standard buffy coats. J Immunol Methods 2001;252:93-104.
6. Adams MR, Dumont LJ, McCall M, Heaton WA. Clinical trial and local process evaluation of an apheresis system for preparation of white cell-reduced platelet components. Transfusion 1998;38:966-74.
7. Neron S, Thibault L, Dussault N, Cote G, Ducas E, Pineault N, et al. Characterization of mononuclear cells remaining in the leukoreduction system chambers of apheresis instruments after routine platelet collection: a new source of viable human blood cells. Transfusion 2007;47:1042-9.
8. Dietz AB, Bulur PA, Emery RL, Winters JL, Epps DE, Zubair AC, et al. A novel source of viable peripheral blood mononuclear cells from leukoreduction system chambers. Transfusion 2006;46:2083-9.
9. Karimi K, Boudreau JE, Fraser K, Liu H, Delanghe J, Gauldie J, et al. Enhanced antitumor immunity elicited by dendritic cell vaccines is a result of their ability to engage both CTL and IFN gamma-producing NK cells. Mol Ther 2007;16:411-8.
10. Lee JJ, Nam CE, Nam JH, Lee HC, Chung IJ, Park MS, et al. Generation of cytotoxic donor CD8+ T cells against relapsing leukemic cells following allogeneic transplantation by stimulation with leukemic cell- or leukemic lysate pulsed donor cell-derived dendritic cells. Leuk Res 2004;28:517-24.
11. Weitkamp JH and Crowe JE Jr. Blood donor leukocyte reduction filters as a source of human B lymphocytes. Biotechniques 2001;31: 464-6.
12. Teleron AA, Carlson B, Young PP. Blood donor white blood cell reduction filters as a source of human peripheral blood-derived endothelial progenitor cells. Transfusion 2005;45:21-5.
13. Ivanovic Z, Duchez P, Morgan DA, Hermitte F, Lafarge X, Chevaleyre J, et al. Whole-blood leuko-depletion filters as a source of CD 34+ progenitors potentially usable in cell therapy. Transfusion 2006; 46:118-25.
14. Pickl WF, Majdic O, Kohl P, Stockl J, Riedl E, Scheinecker C, et al. Molecular and functional characteristics of dendritic cells generated from highly purified CD14+ peripheral blood monocytes. J Immunol 1996;157:3850-9.
15. Reddy A, Sapp M, Feldman M, Subklewe M, Bhardwaj N. A monocyte conditioned medium is more effective than defined cytokines in mediating the terminal maturation of human dendritic cells. Blood 1997;90:3640-6.