Evidence of orbital B and T cell depletion after rituximab therapy in Graves' ophthalmopathy

Acta Ophthalmologica

Volumn 87, Issue 8, 2009, Pages 927-929

  Nielsen, Jacob F ^a   El Fassi, Daniel ^b,c   Nielsen, Claus H ^c   Hegedüs, Laszlo ^b   Lauer, Simeon A ^d   Silkiss, Rona Z ^e   Prause, Jan U ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

^c Rigshospitalet   (Denmark)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^e CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PREDNISOLONE; RITUXIMAB; THYROTROPIN RECEPTOR; THYROTROPIN RECEPTOR ANTIBODY;

ANTIGEN PRESENTATION; B LYMPHOCYTE; CASE REPORT; CELL COUNT; CELL DIFFERENTIATION; DRUG MECHANISM; ENDOCRINE OPHTHALMOPATHY; HUMAN; HUMAN CELL; HUMAN TISSUE; LETTER; LYMPHOCYTE DEPLETION; ORBIT; PRIORITY JOURNAL; T CELL DEPLETION;

ANTIBODIES, MONOCLONAL; B-LYMPHOCYTES; GRAVES OPHTHALMOPATHY; HUMANS; IMMUNOLOGIC FACTORS; LYMPHOCYTE DEPLETION; ORBIT; T-LYMPHOCYTES;

EID: 73349090233     PISSN: 1755375X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1755-3768.2009.01647.x     Document Type: Letter

References (5)

1. El Fassi D, Nielsen CH, Hasselbalch HC Hegedüs L (2006 Treatment-resistant severe, active Graves' ophthalmopathy successfully treated with B lymphocyte depletion. Thyroid 16 : 709 710.
2. El Fassi D, Nielsen CH, Kjeldsen J, Clemmensen O Hegedüs L (2008 Ulcerative colitis following B lymphocyte depletion with rituximab in a patient with Graves' disease. Gut 57 : 714 715.
3. El Fassi D, Banga JP, Gilbert JA, Padoa C, Hegedüs L Nielsen CH (2009 Treatment of Graves' disease with rituximab specifically reduces the production of thyroid stimulating autoantibodies. Clin Immunol 130 : 252 258.
4. Salvi M, Vannucchi G, Campi I et al. (2006 Efficacy of rituximab treatment for thyroid-associated ophthalmopathy as a result of intraorbital B cell depletion in one patient unresponsive to steroid immunosuppression. Eur J Endocrinol 154 : 511 517.
5. Salvi M, Vannucchi G, Campi I et al. (2007 Treatment of Graves' disease and associated ophthalmopathy with the anti-CD20 monoclonal antibody rituximab: an open study. Eur J Endocrinol 156 : 33 40.