Clinical utility of chimerism status assessed by lineage-specific short tandem repeat analysis: Experience from Four Cases of Allogeneic Stem Cell Transplantation

Korean Journal of Laboratory Medicine

Volumn 29, Issue 4, 2009, Pages 277-281

  Goh, Ri Young ^a   Cho, Sung Suk ^a   Song, Yoo Jeong ^a   Heo, Kyeong ^a   Oh, Sung Yong ^a   Kim, Sung Hyun ^a   Kwon, Hyeok Chan ^a   Kim, Hyo Jin ^a   Han, Jin Yeong ^a  

^a Dong A University College of Medicine   (South Korea)

Author keywords

Lineage specific chimerism; Myeloablative stem cell transplantation; Myeloid malignancy; NK cells; T cells

Indexed keywords

MICROSATELLITE DNA;

ADULT; ALLOTRANSPLANTATION; ARTICLE; CASE REPORT; CHIMERA; CYTOLOGY; GENETICS; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNOLOGY; MALE; MIDDLE AGED; NATURAL KILLER CELL; POLYMERASE CHAIN REACTION; PREDICTION AND FORECASTING; STEM CELL TRANSPLANTATION; T LYMPHOCYTE;

ADULT; CHIMERISM; GRAFT VS HOST DISEASE; HUMANS; KILLER CELLS, NATURAL; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE OF TESTS; STEM CELL TRANSPLANTATION; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS;

EID: 73349089020     PISSN: 15986535     EISSN: None     Source Type: Journal    
DOI: 10.3343/kjlm.2009.29.4.277     Document Type: Article

References (13)

1. Weng L, Dyson J, Dazzi F. Low-intensity transplant regimens facilitate recruitment of donor-specific regulatory T cells that promote hematopoietic engraftment. Proc Natl Acad Sci USA 2007;104:8415-20.
2. Lobashevsky AL, Senkbeil RW, Townsend JE, Mink CA, Thomas JM. Quantitative analysis of chimerism using a short tandem repeat method on a fluorescent automated DNA sequencer. Clin Lab Haematol 2006;28:40-9.
3. Lassaletta A, Ramírez M, Montero JM, González-Vicent M, Balas A, Madero L, et al. Full donor chimerism by day 30 after allogeneic peripheral blood progenitor cell transplantation is associated with a low risk of relapse in pediatric patients with hematological malignancies. Leukemia 2005;19:504-6.
4. Bader P, Niethammer D, Willasch A, Kreyenberg H, Klingebiel T. How and when should we monitor chimerism after allogeneic stem cell transplantation? Bone Marrow Transplant 2005;35:107-19.
5. Baron F and Sandmaier BM. Chimerism and outcomes after allogeneic hematopoietic cell transplantation following nonmyeloablative conditioning. Leukemia 2006;20:1690-700.
6. Fernández-Avilés F, Urbano-Ispizua A, Aymerich M, Colomer D, Rovira M, Martínez C, et al. Serial quantification of lymphoid and myeloid mixed chimerism using multiplex PCR amplification of short tandem repeat-markers predicts graft rejection and relapse, respectively, after allogeneic transplantation of CD34+ selected cells from peripheral blood. Leukemia 2003;17:613-20.
7. Bader P, Stoll K, Huber S, Geiselhart A, Handgretinger R, Niemeyer C, et al. Characterization of lineage-specific chimaerism in patients with acute leukaemia and myelodysplastic syndrome after allogeneic stem cell transplantation before and after relapse. Br J Haematol 2000;108:761-78.
8. Huisman C, de Weger RA, de Vries L, Tilanus MG, Verdonck LF. Chimerism analysis within 6 months of allogeneic stem cell transplantation predicts relapse in acute myeloid leukemia. Bone Marrow Transplant 2007;39:285-91.
9. Zeiser R, Spyridonidis A, Wäsch R, Ihorst G, Grüllich C, Bertz H, et al. Evaluation of immunomodulatory treatment based on conventional and lineage-specific chimerism analysis in patients with myeloid malignancies after myeloablative allogeneic hematopoietic cell transplantation. Leukemia 2005;19:814-21.
10. Miura Y, Tanaka J, Toubai T, Tsutsumi Y, Kato N, Hirate D, et al. Analysis of donor-type chimerism in lineage-specific cell populations after allogeneic myeloablative and non-myeloablative stem cell transplantation. Bone Marrow Transplant 2006;37:837-43.
11. Matthes-Martin S, Lion T, Haas OA, Frommlet F, Daxberger H, König M, et al. Lineage-specific chimaerism after stem cell transplantation in children following reduced intensity conditioning: potential predictive value of NK cell chimaerism for late graft rejection. Leukemia 2003;17:1934-42.
12. Michallet AS, Fürst S, Le QH, Dubois V, Praire A, Nicolini F, et al. Impact of chimaerism analysis and kinetics on allogeneic haematopoietic stem cell transplantation outcome after conventional and reduced-intensity conditioning regimens. Br J Haematol 2005;128: 676-89.
13. Mattsson J, Uzunel M, Brune M, Hentschke P, Barkholt L, Stierner U, et al. Mixed chimaerism is common at the time of acute graft-versus-host disease and disease response in patients receiving non-myeloablative conditioning and allogeneic stem cell transplantation. Br J Haematol 2001;115:935-44.