Analysis of an anomalous mutant of MutM DNA glycosylase leads to new insights into the catalytic mechanism

Journal of the American Chemical Society

Volumn 131, Issue 51, 2009, Pages 18208-18209

  Nam, Kwangho ^a   Verdine, Gregory L ^a,b,c,d   Karplus, Martin ^a,e  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD UNIVERSITY   (United States)

^c Harvard University   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e UNIVERSITÉ LOUIS PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

8-OXOGUANINE; ACTIVE SITE; BASE EXTRUSION; CATALYTIC MECHANISMS; CHEMICAL EQUATIONS; DNA GLYCOSYLASE; FREE ENERGY SURFACE; FREE-ENERGY SIMULATION; POTENTIALS OF MEAN FORCES; PROTONATED; RECOGNITION MECHANISM; SPECIFIC RECOGNITION; THERMODYNAMIC INTEGRATION; WILD TYPES;

CHEMICAL REACTIONS; DNA; ENZYMES; EXTRUSION; GENES; THERMODYNAMICS;

FREE ENERGY;

8 HYDROXYGUANINE; DNA GLYCOSYLASE MUTM; GLYCOSYLTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; ENZYME ANALYSIS; ENZYME BINDING; ENZYME STRUCTURE; KINETICS; MUTATION; PROTON TRANSPORT; SIMULATION; THERMODYNAMICS;

BACTERIAL PROTEINS; CATALYSIS; CATALYTIC DOMAIN; COMPUTER SIMULATION; DNA GLYCOSYLASES; GLUTAMIC ACID; GUANINE; MUTANT PROTEINS; MUTATION; THERMODYNAMICS;

EID: 73249150721     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja907544b     Document Type: Article

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