Anti-β2 glycoprotein-I antibody increases the risk of pregnancy-induced hypertension: a case-controlled study

Journal of Reproductive Immunology

Volumn 84, Issue 1, 2010, Pages 95-99

  Yamada, Hideto ^a   Atsumi, Tatsuya ^b   Amengual, Olga ^b   Koike, Takao ^b   Furuta, Itsuko ^b   Ohta, Kaori ^c   Kobashi, Gen ^c  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

Anti 2 glycoprotein I antibody; Anti phospholipid antibody; Preeclampsia; Pregnancy induced hypertension

Indexed keywords

BETA2 GLYCOPROTEIN 1 ANTIBODY; CARDIOLIPIN ANTIBODY; KININOGEN; LUPUS ANTICOAGULANT; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; PHOSPHOLIPID ANTIBODY; PROTHROMBIN ANTIBODY; BETA2 GLYCOPROTEIN 1; CARDIOLIPIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; PROTHROMBIN;

ADULT; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; BLOOD PRESSURE MONITORING; CASE STUDY; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; MATERNAL HYPERTENSION; MULTIPARA; PREECLAMPSIA; PRIORITY JOURNAL; RISK FACTOR; SYSTOLIC BLOOD PRESSURE; BLOOD; CASE CONTROL STUDY; COHORT ANALYSIS; IMMUNOLOGY; JAPAN; PREGNANCY;

ADULT; ANTIBODIES, ANTIPHOSPHOLIPID; BETA 2-GLYCOPROTEIN I; CARDIOLIPINS; CASE-CONTROL STUDIES; COHORT STUDIES; FEMALE; HUMANS; HYPERTENSION, PREGNANCY-INDUCED; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; JAPAN; KININOGENS; LUPUS COAGULATION INHIBITOR; PREGNANCY; PROTHROMBIN; RISK FACTORS; YOUNG ADULT;

EID: 73249143319     PISSN: 01650378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jri.2009.10.005     Document Type: Article

References (24)

1. Ailus K., Tulppala M., Palosuo T., Ylikorkala O., and Vaarala O. Antibodies to beta 2-glycoprotein I and prothrombin in habitual abortion. Fertil. Steril. 66 (1996) 937-941
2. Amengual O., Atsumi T., Khamashta M., Koike T., and Hughes G.R.V. Specificity of ELISA for antibody to beta2-glycoprotein I in patients with anti-phospholipid syndrome. Br. J. Rheumatol. 35 (1996) 1239-1243
3. Arnold J., Holmes Z., Pickering W., Farmer C., Regan L., and Cohen H. Anti-beta 2 glycoprotein 1 and anti-annexin V antibodies in women with recurrent miscarriage. Br. J. Haematol. 113 (2001) 911-914
4. de Laat B., Derksen R.H., Urbanus R.T., and de Groot P.G. IgG antibodies that recognize epitope Gly40-Arg43 in domain I of beta 2-glycoprotein I cause lupus anticoagulantC, and their presence correlates strongly with thrombosis. Blood 105 (2004) 1540-1545
5. D'Ippolito S., Di Simone N., Di Nicuolo F., Castellani R., and Caruso A. Antiphospholipid antibodies: effects on trophoblast and endothelial cells. Am. J. Reprod. Immunol. 58 (2007) 150-158
6. Di Simone N., Raschi E., Testoni C., Castellani R., D'Asta M., Shi T., Krilis S.A., Caruso A., and Meroni P.L. Pathogenic role of anti-beta 2-glycoprotein I antibodies in antiphospholipid associated fetal loss: characterisation of beta 2-glycoprotein I binding to trophoblast cells and functional effects of anti-beta 2-glycoprotein I antibodies in vitro. Ann. Rheum. Dis. 64 (2005) 462-467
7. Di Simone N., Meroni P.L., D'Asta M., Di Nicuolo F., D'Alessio M.C., and Caruso A. Pathogenic role of anti-beta2-glycoprotein I antibodies on human placenta: functional effects related to implantation and roles of heparin. Hum. Reprod. Update 13 (2007) 189-196
8. Falcón C.R., Martinuzzo M.E., Forastiero R.R., Cerrato G.S., and Carreras L.O. Pregnancy loss and autoantibodies against phospholipid-binding proteins. Obstet. Gynecol. 89 (1997) 975-980
9. Faden D., Tincani A., Tanzi P., Spatola L., Lojacono A., Tarantini M., and Balestrieri G. Anti-beta 2 glycoprotein I antibodies in a general obstetric population: preliminary results on the prevalence and correlation with pregnancy outcome. Anti-beta2 glycoprotein I antibodies are associated with some obstetrical complications, mainly preeclampsia-eclampsia. Eur. J. Obstet. Gynecol. Reprod. Biol. 73 (1997) 37-42
10. Forastiero R.R., Martinuzzo M.E., Cerrato G.S., Kordich L.C., and Carreras L.O. Relationship of anti beta2-glycoprotein I and anti prothrombin antibodies to thrombosis and pregnancy loss in patients with antiphospholipid antibodies. Thromb. Haemost. 78 (1997) 1008-1014
11. Hulstein J.J., Lenting P.J., de Laat B., Derksen R.H., Fijnheer R., and de Groot P.G. beta2-Glycoprotein I inhibits von Willebrand factor dependent platelet adhesion and aggregation. Blood 110 (2007) 1483-1491
12. Lee R.M., Emlen W., Scott J.R., Branch D.W., and Silver R.M. Anti-beta2-glycoprotein I antibodies in women with recurrent spontaneous abortion, unexplained fetal death, and antiphospholipid syndrome. Am. J. Obstet. Gynecol. 181 (1999) 642-648
13. Lee R.M., Brown M.A., Branch D.W., Ward K., and Silver R.M. Anticardiolipin and anti-beta2-glycoprotein-I antibodies in preeclampsia. Obstet. Gynecol. 102 (2003) 294-300
14. Lynch A., Byers T., Emlen W., Rynes D., Shetterly S.M., and Hamman R.F. Association of antibodies to beta2-glycoprotein 1 with pregnancy loss and pregnancy-induced hypertension: a prospective study in low-risk pregnancy. Obstet. Gynecol. 93 (1999) 193-198
15. Martinuzzo M.E., Forastiero R.R., and Carreras L.O. Anti beta 2 glycoprotein I antibodies: detection and association with thrombosis. Br. J. Haematol. 89 (1995) 397-402
16. Miyakis S., Lockshin M.D., Atsumi T., Branch D.W., Brey R.L., Cervera R., Derksen R.H., Groot D.E., Koike P.G., Meroni T., Reber P.L., Shoenfeld G., Tincani Y., Vlachoyiannopoulos A., Krilis P.G., and S.A. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J. Thromb. Haemost. 4 (2006) 295-306
17. Pengo V., Biasiolo A., Pegoraro C., Cucchini U., Noventa F., and Iliceto S. Antibody profiles for the diagnosis of antiphospholipid syndrome. Thromb. Haemost. 93 (2005) 1147-1152
18. Sailer T., Zoghlami C., Kurz C., Rumpold H., Quehenberger P., Panzer S., and Pabinger I. Anti-beta2-glycoprotein I antibodies are associated with pregnancy loss in women with the lupus anticoagulant. Thromb. Haemost. 95 (2006) 796-801
19. Sanmarco M., Gayet S., Alessi M.C., Audrain M., de Maistre E., Gris J.C., de Groot P.G., Hachulla E., Harlé J.R., Sié P., and Boffa M.C. Antiphosphatidylethanolamine antibodies are associated with an increased odds ratio for thrombosis. Thromb. Haemost. 97 (2007) 949-954
20. Stern C., Chamley L., Hale L., Kloss M., Speirs A., and Baker H.W. Antibodies to beta2 glycoprotein I are associated with in vitro fertilization implantation failure as well as recurrent miscarriage: results of a prevalence study. Fertil. Steril. 70 (1998) 938-944
21. Wilson W.A., Gharavi A.E., Koike T., Lockshin M.D., Branch D.W., Piette J.C., Brey R., Derksen R., Harris E.N., Hughes G.R., Triplett D.A., and Khamashta M.A. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum. 42 (1999) 1309-1311
22. Yamada H., Atsumi T., Kobashi G., Ota C., Kato E.H., Tsuruga N., Ohta K., Yasuda S., Koike T., and Minakami H. Antiphospholipid antibodies increase the risk of pregnancy-induced hypertension and adverse pregnancy outcomes. J. Reprod. Immunol. 79 (2009) 188-195
23. Zanon E., Prandoni P., Vianello F., Saggiorato G., Carraro G., Bagatella P., and Girolami A. Anti-beta2-glycoprotein I antibodies in patients with acute venous thromboembolism: prevalence and association with recurrent thromboembolism. Thromb. Res. 96 (1999) 269-274
24. Zoghlami-Rintelen C., Vormittag R., Sailer T., Lehr S., Quehenberger P., Rumpold H., Male C., and Pabinger I. The presence of IgG antibodies against beta2-glycoprotein I predicts the risk of thrombosis in patients with the lupus anticoagulant. J. Thromb. Haemost. 3 (2005) 1160-1165