Serum γ-glutamyltransferase: Linking together environmental pollution, redox equilibria and progression of atherosclerosis?

Clinical Chemistry and Laboratory Medicine

Volumn 47, Issue 12, 2009, Pages 1583-1584

  Pompella, Alfonso ^a   Emdin, Michele ^b   Franzini, Maria ^c   Paolicchi, Aldo ^a  

^a UNIVERSITY OF PISA   (Italy)

^b CNR   (Italy)

^c SCUOLA SUPERIORE SANT ANNA   (Italy)

Author keywords

glutamyltransferase; Atherosclerosis; Environmental pollutants; Redox equilibria

Indexed keywords

FERRITIN; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE; PHOSPHATASE; PROTEIN KINASE; PROTEIN S; SUPEROXIDE; TRANSCRIPTION FACTOR AP 1; TRANSFERRIN;

ATHEROSCLEROSIS; BLOOD LEVEL; DISEASE COURSE; HUMAN; IRON TRANSPORT; LETTER; OXIDATION REDUCTION STATE; POLLUTION; PRIORITY JOURNAL; PROGNOSIS;

ATHEROSCLEROSIS; DISEASE PROGRESSION; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; OXIDATION-REDUCTION;

EID: 73249131641     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2009.350     Document Type: Letter

References (12)

1. Lee DS, Evans JC, Robins SJ, Wilson PW, Albano I, Fox CS, et al. Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study. Arterioscler Thromb Vasc Biol 2007;27:4-7.
2. Strasak AM, Kelleher CC, Klenk J, Brant LJ, Ruttmann E, Rapp K, et al. Longitudinal change in serum gammaglutamyltransferase and cardiovascular disease mortality - a prospective population-based study in 76113 Austrian adults. Arterioscl Thromb Vasc Biol 2008;28:1857-1865
3. Franzini M, Corti A, Martinelli B, Del Corso A, Emdin M, Parenti GF, et al. Gamma-glutamyltransferase activity in human atherosclerotic plaques - biochemical similarities with the circulating enzyme. Atherosclerosis 2009; 202:119-127
4. Lee DH, Jacobs DR. Is serum gamma-glutamyltransferase an exposure marker of xenobiotics? Empirical evidence with polycylic aromatic hydrocarbon. Clin Chem Lab Med 2009;47:860-862
5. Lee DH, Jacobs DR. Association between serum concentrations of persistent organic pollutants and gamma glutamyltransferase: results from the National Health and Examination Survey 1999-2002. Clin Chem 2006;52: 1825-1827
6. 2 production and S-thiolation. Free Rad Biol Med 1999;27:623-635
7. Paolicchi A, Dominici S, Pieri L, Maellaro E, Pompella A. Glutathione catabolism as a signalling mechanism. Bioch Pharmacol 2002;64:1029-1037
8. Pang JH, Jiang MJ, Chen YL, Wang FW, Wang DL, Chu SH, et al. Increased ferritin gene expression in atherosclerotic lesions. J Clin Invest 1996;97:2204-2212
9. Corti A, Raggi C, Franzini M, Paolicchi A, Pompella A, Casini AF. Plasma membrane gamma-glutamyltransferase activity facilitates the uptake of vitamin C in cancer cells. Free Rad Biol Med 2004;37:1906-1915
10. Corti A, Paolicchi A, Franzini M, Dominici S, Casini AF, Pompella A. The S-thiolating activity of membrane gamma-glutamyltransferase: formation of cysteinyl-glycine mixed disulfides with cellular proteins and in the cell microenvironment. Antiox Redox Signal 2005;7: 911-918
11. Bramanti E, Angeli V, Franzini M, Vecoli C, Baldassini R, Paolicchi A, et al. Exogenous vs. endogenous gammaglutamyltransferase activity: implications for the specific determination of S-nitrosoglutathione in biological samples. Arch Bioch Biophys 2009;487:146-152
12. Franzini M, Bramanti E, Ottaviano V, Ghiri E, Scatena F, Barsacchi R, et al. A high performance gel filtration chromatography method for gamma-glutamyltransferase fraction analysis. Anal Biochem 2008;374:1-6.