Allergic rhinitis with negative skin tests: Does it exist?

Allergy and Asthma Proceedings

Volumn 30, Issue 5, 2009, Pages 465-469

  Khan, David A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Allergen; IgE; Localized; Nasal provocation; Nonallergic; Rhinitis

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN E;

ALLERGIC RHINITIS; CONFERENCE PAPER; DERMATOPHAGOIDES FARINAE; DERMATOPHAGOIDES PTERONYSSINUS; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; HUMAN; IMMUNOGLOBULIN PRODUCTION; IMMUNOPATHOGENESIS; INTRACUTANEOUS TEST; NOSE MUCOSA; NOSE PROVOCATION TEST; SKIN TEST; VASOMOTOR RHINITIS;

ALLERGENS; HUMANS; IMMUNOGLOBULIN E; NASAL PROVOCATION TESTS; RHINITIS; RHINITIS, ALLERGIC, PERENNIAL; RHINITIS, ALLERGIC, SEASONAL; SKIN TESTS;

EID: 73249130588     PISSN: 10885412     EISSN: 15396304     Source Type: Journal    
DOI: 10.2500/aap.2009.30.3265     Document Type: Conference Paper

References (18)

1. Settipane RA. Rhinitis: A dose of epidemiological reality. Allergy Asthma Proc 24:147-154, 2003.
2. Settipane RA, and Charnock DR. Epidemiology of rhinitis: Allergic and nonallergic. Clin Allergy Immunol 19:23-34, 2007.
3. Bousquet J, Fokkens W, Burney P, et al. Important research questions in allergy and related diseases: Nonallergic rhinitis: A GA2LEN paper. Allergy 63:842-853, 2008.
4. Wallace DV, Dykewicz MS, Bernstein DI, et al. The diagnosis and management of rhinitis: An updated practice parameter. J Allergy Clin Immunol 122:S1-S84, 2008.
5. Broide DH. The pathophysiology of allergic rhinoconjunctivitis. Allergy Asthma Proc 28:398-403, 2007.
6. Powe DG, Huskisson RS, Carney AS, et al. Evidence for an inflammatory pathophysiology in idiopathic rhinitis. Clin Exp Allergy 31:864-872, 2001.
7. Zurcher AW, Derer T, Lang AB, and Stadler BM. Culture and IgE synthesis of nasal B cells. Int Arch Allergy Immunol 111: 77-82, 1996.
8. Durham SR, Gould HJ, Thienes CP, et al. Expression of epsilon germ-line gene transcripts and mRNA for the epsilon heavy chain of IgE in nasal B cells and the effects of topical corticosteroid. Eur J Immunol 27:2899-2906, 1997.
9. KleinJan A, Vinke JG, Severijnen LW, and Fokkens WJ. Local production and detection of (specific) IgE in nasal B-cells and plasma cells of allergic rhinitis patients. Eur Respir J 15:491-497, 2000.
10. Takhar P, Smurthwaite L, Coker HA, et al. Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis. J Immunol 174:5024-5032, 2005.
11. Huggins KG, and Brostoff J. Local production of specific IgE antibodies in allergic-rhinitis patients with negative skin tests. Lancet 2:148-150, 1975.
12. Carney AS, Powe DG, Huskisson RS, and Jones NS. Atypical nasal challenges in patients with idiopathic rhinitis: More evidence for the existence of allergy in the absence of atopy? Clin Exp Allergy 32:1436-1440, 2002.
13. Johansson SG, Hourihane JO, Bousquet J, et al. A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy 56:813-824, 2001.
14. Powe DG, Jagger C, Kleinjan A, et al. "Entopy": Localized mucosal allergic disease in the absence of systemic responses for atopy. Clin Exp Allergy 33:1374-1379, 2003.
15. Rondon C, Romero JJ, Lopez S, et al. Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis. J Allergy Clin Immunol 119:899-905, 2007.
16. Wierzbicki DA, Majmundar AR, Schull DE, and Khan DA. Multiallergen nasal challenges in nonallergic rhinitis. Ann Allergy Asthma Immunol 100:533-537, 2008.
17. Lebel B, Bousquet J, Morel A, et al. Correlation between symptoms and the threshold for release of mediators in nasal secretions during nasal challenge with grass-pollen grains. J Allergy Clin Immunol 82:869-877, 1988.
18. Nelson HS, Oppenheimer J, Buchmeier A, et al. An assessment of the role of intradermal skin testing in the diagnosis of clinically relevant allergy to timothy grass. J Allergy Clin Immunol 97:1193-1201, 1996.