Pesticide use and adult-onset asthma among male farmers in the Agricultural Health Study

European Respiratory Journal

Volumn 34, Issue 6, 2009, Pages 1296-1303

  Hoppin, J A ^a   Umbach, D M ^a   London, S J ^a   Henneberger, P K ^c   Kullman, G J ^c   Coble, J ^b   Alavanja, M C R ^b   Beane Freeman, L E ^b   Sandler, D P ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Allergy; Farming; Occupational exposure; Pesticides; Respiratory disease

Indexed keywords

1,2 DIBROMOETHANE; CARBON DISULFIDE; CARBON TETRACHLORIDE; CHLORPHENOTANE; COUMAFOS; HEPTACHLOR; PARATHION; PESTICIDE;

ADULT; AGRICULTURAL WORKER; ALLERGIC ASTHMA; ARTICLE; ASTHMA; BODY MASS; CAUSAL ATTRIBUTION; CONTROLLED STUDY; HUMAN; MAJOR CLINICAL STUDY; MALE; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; WHEEZING;

ADULT; AGED; AGRICULTURAL WORKERS' DISEASES; AGRICULTURE; ASTHMA; CARBON DISULFIDE; CARBON TETRACHLORIDE; DDT; ETHYLENE DIBROMIDE; HUMANS; IOWA; MALE; MIDDLE AGED; NORTH CAROLINA; OCCUPATIONAL EXPOSURE; PARATHION; PESTICIDES; PROSPECTIVE STUDIES; QUESTIONNAIRES; SMOKING;

EID: 73249125865     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00005509     Document Type: Article

References (32)

1. Senthilselvan A, McDuffie HH, Dosman JA. Association of asthma with use of pesticides - results of a cross-sectional survey of farmers. Am Rev Respir Dis 1992; 146: 884-887.
2. Hoppin JA, Umbach DM, London SJ, et al. Pesticides and atopic and nonatopic asthma among farm women in the Agricultural Health Study. Am J Respir Crit Care Med 2008; 177: 11-18.
3. Beard J, Sladden T, Morgan G, et al. Health impacts of pesticide exposure in a cohort of outdoor workers. Environ Health Perspect 2003; 111: 724-730.
4. Hoppin JA, Umbach DM, London SJ, et al. Chemical predictors of wheeze among farmer pesticide applicators in the Agricultural Health Study. Am J Respir Crit Care Med 2002; 165: 683-689.
5. Hoppin JA, Umbach DM, London SJ, et al. Pesticides associated with wheeze among commercial pesticide applicators in the Agricultural Health Study. Am J Epidemiol 2006; 163: 1129-1137.
6. Ohayo-Mitoko GJA, Kromhout H, Simwa JM, et al. Self reported symptoms and inhibition of acetylcholinesterase activity among Kenyan agricultural workers. Occup Environ Med 2000; 57: 195-200.
7. Fryer AD, Lein PJ, Howard AS, et al. Mechanisms of organophosphate insecticide-induced airway hyperreactivity. Am J Physiol Lung Cell Mol Physiol 2004; 286: L963-L969.
8. Lein PJ, Fryer AD. Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of acetylcholinesterase inhibition. Toxicol Sci 2005; 83: 166-176.
9. Proskocil BJ, Bruun DA, Lorton JK, et al. Antigen sensitization influences organophosphorus pesticide-induced airway hyperreactivity. Environ Health Perspect 2008; 116: 381-388.
10. Eduard W, Omenaas E, Bakke PS, et al. Atopic and non-atopic asthma in a farming and a general population. Am J Ind Med 2004; 46: 396-399.
11. Alavanja MC, Sandler DP, McMaster SB, et al. The Agricultural Health Study. Environ Health Perspect 1996; 104: 362-369.
12. Tarone RE, Alavanja MC, Zahm SH, et al. The Agricultural Health Study: factors affecting completion and return of self-administered questionnaires in a large prospective cohort study of pesticide applicators. Am J Ind Med 1997; 31: 233-242.
13. Agricultural Health StudyFull text of questionnaires. www. aghealth.org/questionnaires.html Date last updated: December, 2008. Date last accessed: October 14, 2009.
14. Dosemeci M, Alavanja MC, Rowland AS, et al. A quantitative approach for estimating exposure to pesticides in the Agricultural Health Study. Ann Occup Hyg 2002; 46: 245-260.
15. Schenker MB, Christiani D, Cormier Y, et al. Respiratory health hazards in agriculture. Am J Respir Crit Care Med 1998; 158: Suppl. S, S1-S76.
16. Castro-Gutierrez N, McConnell R, Andersson K, et al. Respiratory symptoms, spirometry and chronic occupational paraquat exposure. Scand J Work Environ Health 1997; 23: 421-427.
17. Hernandez AF, Casado I, Pena G, et al. Low level of exposure to pesticides leads to lung dysfunction in occupationally exposed subjects. Inhal Toxicol 2008; 20: 839-849.
18. Bell EM, Sandler DP, Alavanja MC. High pesticide exposure events among farmers and spouses enrolled in the Agricultural Health Study. J Agric Saf Health 2006; 12: 101-116.
19. Hoppin JA, Valcin M, Henneberger PK, et al. Pesticide use and chronic bronchitis among farmers in the Agricultural Health Study. Am J Ind Med 2007; 50: 969-979.
20. Hoppin JA, Umbach DM, Kullman GJ, et al. Pesticides and other agricultural factors associated with self-reported farmer's lung among farm residents in the Agricultural Health Study. Occup Environ Med 2007; 64: 334-341.
21. Beseler C, Stallones L, Hoppin JA, et al. Depression and pesticide exposures among private pesticide applicators enrolled in the Agricultural Health Study. Environ Health Perspect 2008; 116: 1713-1719.
22. Kamel F, Engel LS, Gladen BC, et al. Neurologic symptoms in licensed pesticide applicators in the Agricultural Health Study. Hum Exp Toxicol 2007; 26: 243-350.
23. Dalvie MA, White N, Raine R, et al. Long-term respiratory health effects of the herbicide, paraquat, among workers in the Western Cape. Occup Environ Med 1999; 56: 391-396.
24. Schenker MB, Stoecklin M, Lee K, et al. Pulmonary function and exercise-associated changes with chronic low-level paraquat exposure. Am J Respir Crit Care Med 2004; 170: 773-779.
25. Chatzi L, Alegakis A, Tzanakis N, et al. Association of allergic rhinitis with pesticide use among grape farmers in Crete, Greece. Occup Environ Med 2007; 64: 417-421.
26. Upton MN, McConnachie A, McSharry C, et al. Intergenerational 20 year trends in the prevalence of asthma and hay fever in adults: the Midspan family study surveys of parents and offspring. BMJ 2000; 321: 88-92.
27. Dong W, Gilmour MI, Lambert AL, et al. Enhanced allergic responses to house dust mite by oral exposure to carbaryl in rats. Toxicol Sci 1998; 44: 63-69.
28. Blair A, Zahm SH. Patterns of pesticide use among farmers: implications for epidemiologic research. Epidemiology 1993; 4: 55-62.
29. Hoppin JA, Yucel F, Dosemeci M, et al. Accuracy of self-reported pesticide use duration information from licensed pesticide applicators in the Agricultural Health Study. J Expo Anal Environ Epidemiol 2002; 12: 313-318.
30. Coble J, Arbuckle T, Lee W, et al. The validation of a pesticide exposure algorithm using biological monitoring results. J Occup Environ Hyg 2005; 2: 194-201.
31. Burney PG, Laitinen LA, Perdrizet S, et al. Validity and repeatability of the IUATLD (1984) Bronchial Symptoms Questionnaire: an international comparison. Eur Respir J 1989; 2: 940-945.
32. Jenkins MA, Clarke JR, Carlin JB, et al. Validation of questionnaire and bronchial hyperresponsiveness against respiratory physician assessment in the diagnosis of asthma. Int J Epidemiol 1996; 25: 609-616.