DNA plasticity is a key determinant of the energetics of binding of Jun-Fos heterodimeric transcription factor to genetic variants of TGACGTCA motif

Biochemistry

Volumn 48, Issue 51, 2009, Pages 12213-12222

  Seldeen, Kenneth L ^a   McDonald, Caleb B ^a   Deegan, Brian J ^a   Bhat, Vikas ^a   Farooq, Amjad ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGETICS; CELL SURFACES; CELLULAR PROCESS; CIRCULAR DICHROISM; CONFORMATIONAL SPACE; DRUG DESIGN; ENTHALPY-ENTROPY COMPENSATION; FREE ENERGY OF BINDING; GENETIC VARIANTS; GENETIC VARIATION; HETERODIMERS; HIGH AFFINITY; ISOTHERMAL TITRATION CALORIMETRY; KEY DETERMINANTS; PROTEIN-DNA INTERACTIONS; SIGNALING CASCADES; SINGLE NUCLEOTIDES;

BIOLOGICAL SYSTEMS; CELL MEMBRANES; DICHROISM; DNA; DRUG INTERACTIONS; ENTHALPY; ENTROPY; FOOD ADDITIVES; GENES; PLASTICITY; TRANSCRIPTION; TRANSCRIPTION FACTORS;

BINDING ENERGY;

AMINO ACID; DNA; NUCLEIC ACID BINDING PROTEIN; PROTEIN FOS; PROTEIN JUN; THREONYLGLYCYLALANYLCYSTEINYLGLYCYLTHREONYLCYSTEINYLALANINE; UNCLASSIFIED DRUG;

ARTICLE; BASIC LEUCINE ZIPPER MOTIF; CIRCULAR DICHROISM; ENERGY TRANSFER; GENETIC VARIABILITY; ISOTHERMAL TITRATION CALORIMETRY; PLASTICITY; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES; DIMERIZATION; DNA; GENETIC VARIATION; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN;

EID: 73149113303     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901392k     Document Type: Article

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