Transient kinetic analysis of the interaction of L-serine with Escherichia coli D-3-phosphoglycerate dehydrogenase reveals the mechanism of V-type regulation and the order of effector binding

Biochemistry

Volumn 48, Issue 51, 2009, Pages 12242-12251

  Burton, Rodney L ^a,b   Chen, Shawei ^a   Xu, Xiao Lan ^a   Grant, Gregory A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SPECIES; BINDING MECHANISMS; CONFORMATIONAL CHANGE; COOPERATIVITY; D-3- PHOSPHOGLYCERATE DEHYDROGENASE; DISSOCIATION CONSTANT; EFFECTOR BINDING; FLUORESCENT SIGNALS; KINETIC MECHANISM; L-SERINE; PRE-STEADY STATE; QUATERNARY COMPLEXES; SERINE BINDING; SERINE INHIBITION; SPECIES DISTRIBUTIONS; STOPPED FLOW; SUBSTRATE BINDING; TRANSIENT KINETIC ANALYSIS;

AMINO ACIDS; COMPLEXATION; DISSOCIATION; ENZYMES; ESCHERICHIA COLI; PHOSPHATASES; RATE CONSTANTS; SUBSTRATES;

BINDING SITES;

DEXTRO 3 PHOSPHOGLYCERATE DEHYDROGENASE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SERINE; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; ENZYME KINETICS; ENZYME SUBSTRATE; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN STRUCTURE;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; ENZYME INHIBITORS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; KINETICS; PHOSPHOGLYCERATE DEHYDROGENASE; PROTEIN BINDING; SERINE;

ESCHERICHIA COLI;

EID: 73149111727     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901489n     Document Type: Article

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