Novel non-invasive approach for visualizing inflamed atherosclerotic plaques using fluorodeoxyglucose-positron emission tomography

Geriatrics and Gerontology International

Volumn 10, Issue 1, 2010, Pages 1-8

  Kai, Hisashi ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Activity; Atherosclerosis; Carotid artery; Inflammation; Nuclear medicine

Indexed keywords

C REACTIVE PROTEIN; CELL ADHESION MOLECULE; CYTOKINE; FLUORODEOXYGLUCOSE F 18; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SIMVASTATIN;

AGE; ANGIOGRAPHY; ANTIINFLAMMATORY ACTIVITY; ARTERY CALCIFICATION; ARTERY OCCLUSION; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; DIABETES MELLITUS; DIET THERAPY; GENDER BIAS; GLUCOSE METABOLISM; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HUMAN; HYPERTENSION; IMAGE ANALYSIS; INTRAVASCULAR ULTRASOUND; LIFESTYLE MODIFICATION; METABOLIC SYNDROME X; MULTIDETECTOR COMPUTED TOMOGRAPHY; NON INVASIVE PROCEDURE; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTICAL COHERENCE TOMOGRAPHY; POSITRON EMISSION TOMOGRAPHY; PREVALENCE; PRIORITY JOURNAL; REVIEW; SENSITIVITY ANALYSIS; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SMOKING;

ATHEROSCLEROSIS; FLUORODEOXYGLUCOSE F18; HUMANS; INFLAMMATION; POSITRON-EMISSION TOMOGRAPHY; TOMOGRAPHY, X-RAY COMPUTED;

EID: 73049085447     PISSN: 14441586     EISSN: 14470594     Source Type: Journal    
DOI: 10.1111/j.1447-0594.2009.00564.x     Document Type: Review

References (42)

1. Goldschmidt-Clemont PJ, Creager MA, Losardo DW, Lam GK, Wassef M, Dzau VJ. Atherosclerosis 2005: recent discovery and novel hypotheses. Circulation 2005, 112:3348-3353.
2. Hansson GK, Libby P. The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol 2006, 6:508-519.
3. Schillaci O, Danieli R, Padovano F, Testa A, Simonetti G. Molecular imaging of atheroslerotic plaque with nuclear medicine techniques. Int J Mol Med 2008, 22:3-7.
4. Sanz J, Fayad ZA. Imaging of atherosclerotic cardiovascular disease. Nature 2008, 451:953-957.
5. Fujisawa M, Okumiya K, Matsubayashi K, Hamada T, Endo H, Doi Y. Factors associated with carotid atherosclerosis in community-dwelling oldest elderly aged over 80 years. Geriatr Gerontol Int 2008, 8:12-18.
6. Takato T, Yamada N, Ashida T. Effects of aging and sex on progression of carotid intima-media thickness: a retrospective 6-year follow-up study. Geriatr Gerontol Int 2008, 8:172-179.
7. Becker CR, Knez A, Ohnesorge B. Visualization and quantification of coronary calcifications with electron beam and spiral computed tomography. Eur Radiol 2000, 10:629-635.
8. Caussin C, Ohanessian AGS, Jacq L. Characterization of vulnerable nonstenotic plaque with 16-slice computed tomography compared with intravascular ultrasound. Am J Cardiol 2004, 94:99-104.
9. Saam T, Kerwin WS, Chu B. Sample size calculation for clinical trials using magnetic resonance imaging for the quantitative assessment of carotid atherosclerosis. J Cardiovasc Magn Reson 2005, 7:799-808.
10. Corti R, Fuster V, Fayad ZA. Lipid lowering by simvastatin induces regression of human atherosclerotic lesions: two years' follow-up by high-resolution noninvasive magnetic resonance imaging. Circulation 2002, 106:2884-2887.
11. Ridker PM, Rifai N, Clearfield M. Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events. N Engl J Med 2001, 344:1959-1965.
12. Ridker PM, Cannon CP, Morrow D. C-reactive protein levels and outcomes after statin therapy. N Engl J Med 2005, 352:20-28. Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) Investigators
13. Koenig W, Khuseyinova N. Biomarkers of atherosclerotic plaque instability and rupture. Arterioscler Thromb Vasc Biol 2007, 27:15-26.
14. Davies JR, Rudd JH, Weissberg PL. Molecular and metabolic imaging of atherosclerosis. J Nucl Med 2004, 45:1898-1907.
15. Delbeke D. Oncological applications of FDG PET imaging. J Nucl Med 1999, 40:1706-1715.
16. Chen W, Bural GG, Torigian DA, Rader DJ, Alavi A. Emerging role of FDG-PET/CT in assessing atherosclerosis in large arteries. Eur J Nucl Med Mol Imaging 2009, 36:144-151.
17. Theron J, Tyler JL. Takayasu's arteritis of the aortic arch: endovascular treatment and correlation with positron emission tomography. AJNR Am J Neuroradiol 1987, 8:621-626.
18. Yun M, Yeh D, Araujo LI, Jang S, Newberg A, Alavi A. F-18 FDG uptake in the large arteries: a new observation. Clin Nucl Med 2001, 26:314-319.
19. Yun M, Jang S, Cucchiara A, Newberg AB, Alavi A. 18F FDG uptake in the large arteries: a correlation study with the atherogenic risk factors. Semin Nucl Med 2002, 32:70-76.
20. Rudd JH, Warburton EA, Fryer TD. Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography. Circulation 2002, 105:2708-2711.
21. Tatsumi M, Cohade C, Nakamoto Y, Wahl RL. Fluorodeoxyglucose uptake in the aortic wall at PET/CT: possible finding for active atherosclerosis. Radiology 2003, 229:831-837.
22. Tahara N, Kai H, Ishibashi M. Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography. J Am Coll Cardiol 2006, 48:1825-1831.
23. Davies JR, Rudd JH, Fryer TD. Identification of culprit lesions after transient ischemic attack by combined 18F fluorodeoxyglucose positron-emission tomography and high-resolution magnetic resonance imaging. Stroke 2005, 36:2642-2647.
24. Rudd JH, Myers KS, Bansilal S. Atherosclerosis inflammation imaging with 18F-FDG PET: carotid, iliac, and femoral uptake reproducibility, quantification methods, and recommendations. J Nucl Med 2008, 49:871-878.
25. Ogawa M, Ishino S, Mukai T. 18)F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study. J Nucl Med 2004, 45:1245-1450.
26. Tawakol A, Migrino RQ, Bashian GG. In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients. J Am Coll Cardiol 2006, 48:1818-1824.
27. Rudd JH, Myers KS, Bansilal S. 18)Fluorodeoxyglucose positron emission tomography imaging of atherosclerotic plaque inflammation is highly reproducible: implications for atherosclerosis therapy trials. J Am Coll Cardiol 2007, 50:892-896.
28. Bural GG, Torigian DA, Chamroonrat W. Quantitative assessment of the atheroslcrotic burden of the aorta by combined FDG-PET and CT image analysis: a new concept. Nucl Med Biol 2006, 33:1037-1043.
29. Tahara N, Kai H, Nakaura H. The prevalence of inflammation in carotid atherosclerosis: analysis with fluorodeoxyglucose-positron emission tomography. Eur Heart J 2007, 28:2243-2248.
30. Tahara N, Kai H, Yamagishi S. Vascular inflammation evaluated by [18F]-fluorodeoxyglucose positron emission tomography is associated with the metabolic syndrome. J Am Coll Cardiol 2007, 49:1533-1539.
31. Nicholls SJ, Tuzcu EM, Sipahi I. Statins, high-density lipoprotein cholesterol, and regression of coronary atherosclerosis. JAMA 2007, 297:499-508.
32. Vaughan CJ, Gotto AM, Basson CT. The evolving role of statins in the management of atherosclerosis. J Am Coll Cardiol 2000, 35:1-10.
33. Libby P, Aikawa M. Mechanisms of plaque stabilization with statins. Am J Cardiol 2003, 91:4B-8B. Suppl
34. Corti R, Fayad ZA, Fuster V. Effects of lipid-lowering by simvastatin on human atherosclerotic lesions: a longitudinal study by high-resolution, noninvasive magnetic resonance imaging. Circulation 2001, 104:249-252.
35. Lee SJ, On YK, Lee EJ, Choi JY, Kim BT, Lee KH. Reversal of vascular 18F-FDG uptake with plasma high-density lipoprotein elevation by atherogenic risk reduction. J Nucl Med 2008, 49:1277-1282.
36. Metter CM, Wyss MT, Meier P. 18F-choline images murine atherosclerotic plaques ex vivo. Arteriosclr Thromb Vasc Biol 2006, 260:584-589.
37. Kietselaer BL, Reutelingsperger CP, Heidendal GA. Noninvasive detection of plaque instability with use of radiolabeled annexin A5 in patients with carotid-artery atherosclerosis. N Engl J Med 2004, 350:1472-1473.
38. Breyholz HJ, Wagner S, Levkau B, Schober O, Schäfers M, Kopka KA. 18F-radiolabeled analogue of CGS 27023A as a potential agent for assessment of matrix-metalloproteinase activity in vivo. Q J Nucl Med Mol Imaging 2007, 51:24-32.
39. Beer AJ, Haubner R, Sarbia M. Positron emission tomography using [18F]Galacto-RGD identifies the level of integrin alpha(v)beta3 expression in man. Clin Cancer Res 2006, 12:3942-3949.
40. Dunphy MP, Strauss HW. Molecular imaging of atherosclerosis. Curr Cardiol Rep 2008, 10:121-127.
41. Hosokawa R, Kambara N, Ohba M. A catheter-based intravascular radiation detector of vulnerable plaques. J Nucl Med 2006, 47:836-867.
42. Paulmier B, Duet M, Khayat R. Arterial wall uptake of fluorodeoxyglucose on PET imaging in stable cancer disease patients indicates higher risk for cardiovascular events. J Nucl Cardiol 2008, 15:209-217.