Archived HIV-1 minority variants detected by ultra-deep pyrosequencing in provirus may be fully replication competent

AIDS

Volumn 23, Issue 18, 2009, Pages 2541-2543

  Rozera, Gabriella ^a   Abbate, Isabella ^a   Bruselles, Alessandro ^a   Vlassi, Chrysoula ^a   D'Offizi, Gianpiero ^a   Narciso, Pasquale ^a   Chillemi, Giovanni ^b   Prosperi, Mattia ^a   Ippolito, Giuseppe ^a   Capobianchi, Maria R ^a  

^a NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

^b CASPUR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5 ANTAGONIST;

GENE SEQUENCE; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LETTER; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROVIRUS; PYROSEQUENCING; VIRUS GENE; VIRUS REPLICATION;

ALGORITHMS; DNA, VIRAL; HIV INFECTIONS; HIV-1; HUMANS; PHYLOGENY; PROVIRUSES; SEQUENCE ANALYSIS, PROTEIN;

EID: 72949121038     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32832fd2e1     Document Type: Letter

References (5)

1. Archer J, Braverman MS, Taillon BE, Desany B, James I, Harrigan PR, et al. Detection of low-frequency pretherapy chemokine (CXC motif) receptor 4 (CXCR4)-using HIV-1 with ultra-deep pyrosequencing. AIDS 2009; 23:1209-1218.
2. Whitcomb JM, Huang W, Fransen S, Limoli K, Toma J, Wrin T, et al. Development and characterization of a novel single-cycle recombinant-virus assay to determine human immunodeficiency virus type 1 coreceptor tropism. Antimicrob Agents Chemother 2007; 51:566-575
3. Rozera G, Abbate I, Bruselles A, Vlassi C, D'Offizi G, Narciso P, et al. Massively parallel pyrosequencing highlights minority variants in the HIV-1 env quasispecies deriving from lympho-monocyte sub-populations. Retrovirology 2009; 12:6-15.
4. Jensen MA, Li FS, van 't Wout AB, Nickle DC, Shriner D, He HX, et al. Improved coreceptor usage prediction and genotypic monitoring of R5-to-X4 transition by motif analysis of HIV-1 env V3 loop sequences. J Virol 2003; 77:13376-13388.
5. Repik A, Richards KH, Clapham PR. The promise of CCR5 antagonists as new therapies for HIV-1. Curr Opin Investig Drugs 2007; 8:130-139.