Qualitative analysis of hippocampal plastic changes in rats with epilepsy supplemented with oral omega-3 fatty acids

Epilepsy and Behavior

Volumn 17, Issue 1, 2010, Pages 33-38

  Cysneiros, Roberta M ^a   Ferrari, Danuza ^b   Arida, Ricardo M ^b   Terra, Vera C ^c   de Almeida, Antonio Carlos G ^d   Cavalheiro, Esper A ^b   Scorza, Fulvio A ^b  

^a MACKENZIE PRESBYTERIAN UNIVERSITY   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d FEDERAL UNIVERSITY OF SÃO JOÃO DEL REI   (Brazil)

Author keywords

Brain derived neurotrophic factor; Epilepsy; Neurogenesis; Omega 3 fatty acids; Oral supplementation

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; DIAZEPAM; DOCOSAHEXAENOIC ACID; FISH OIL; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID; PARVALBUMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CELL SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG CAPSULE; DRUG MECHANISM; DRUG SCREENING; EPILEPSY; EPILEPTIC STATE; HIPPOCAMPUS; INTERNEURON; LONG TERM CARE; MALE; MORNING DOSAGE; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUALITATIVE ANALYSIS; RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTICONVULSANTS; BRAIN-DERIVED NEUROTROPHIC FACTOR; BROMODEOXYURIDINE; DIAZEPAM; DISEASE MODELS, ANIMAL; EPILEPSY; FATTY ACIDS, OMEGA-3; HIPPOCAMPUS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; NEURONAL PLASTICITY; PARVALBUMINS; PILOCARPINE; RATS; RATS, WISTAR;

EID: 72949119531     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2009.11.006     Document Type: Article

References (33)

1. Schlanger S., Shinitzky M., and Yam D. Diet enriched with omega-3 fatty acids alleviates convulsion symptoms in epilepsy patients. Epilepsia 43 (2002) 103-104
2. Voskuyl R.A., Vreugdenhil M., Kang J.X., and Leaf A. Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model. Eur J Pharmacol 341 (1998) 145-152
3. Yehuda S., Carasso R.L., and Mostofsky D.I. Essential fatty acid preparation (SR-3) raises the seizure threshold in rats. Eur J Pharmacol 254 (1994) 193-198
4. Best N., Mitchell J., Baimbridge K.G., and Wheal H.V. Changes in parvalbumin-immunoreactive neurons in the rat hippocampus following a kainic acid lesion. Neurosci Lett 155 (1993) 1-6
5. DeFelipe J. Chandelier cells and epilepsy. Brain 122 Pt. 10 (1999) 1807-1822
6. Van Vliet E.A., Aronica E., Tolner E.A., Lopes da Silva F.H., and Gorter J.A. Progression of TLE in the rat is associated with immunocytochemical changes in inhibitory interneurons in specific regions of the hippocampal formation. Exp Neurol 187 (2004) 367-379
7. Bromfield E., Dworetzky B., Hurwitz S., et al. A randomized trial of polyunsaturated fatty acids for refractory epilepsy. Epilepsy Behav 12 (2008) 187-190
8. Yehuda S. Omega-6/omega-3 ratio and brain-related functions. World Rev Nutr Diet 92 (2003) 37-56
9. Lukiw W.J., Cui J.G., Marcheselli V.L., et al. A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. J Clin Invest 115 (2005) 2774-2783
10. Darios F., and Davletov B. Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3. Nature 440 (2006) 813-817
11. Little S.J., Lynch M.A., Manku M., and Nicolaou A. Docosahexaenoic acid-induced changes in phospholipids in cortex of young and aged rats: a lipidomic analysis. Prostaglandins Leukot Essent Fatty Acids 77 (2007) 155-162
12. Xu X.P., Erichsen D., Börjesson S.I., Dahlin M., Amark P., and Elinder F. Polyunsaturated fatty acids and cerebrospinal fluid from children on the ketogenic diet open a voltage-gated K channel: a putative mechanism of antiseizure action. Epilepsy Res 80 (2008) 57-66
13. Ferrari D., Cysneiros R.M., Scorza C.A., et al. Neuroprotective activity of omega-3 fatty acids against epilepsy-induced hippocampal damage: quantification with immunohistochemical for calcium-binding proteins. Epilepsy Behav 13 (2008) 36-42
14. Dong H., Csernansky C.A., Goico B., and Csernansky J.G. Hippocampal neurogenesis follows kainic acid-induced apoptosis in neonatal rats. J Neurosci 23 (2003) 1742-1749
15. Parent J.M., Janumpalli S., McNamara J.O., and Lowenstein D.H. Increased dentate granule cell neurogenesis following amygdala kindling in the adult rat. Neurosci Lett 247 (1998) 9-12
16. Gray W.P., and Sundstrom L.E. Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat. Brain Res 790 (1998) 52-59
17. Scharfman H.E., Goodman J.H., and Sollas A.L. Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: functional implications of seizure-induced neurogenesis. J Neurosci 20 (2000) 6144-6158
18. Dashtipour K., Tran P.H., Okazaki M.M., Nadler J.V., and Ribak C.E. Ultrastructural features and synaptic connections of hilar ectopic granule cells in the rat dentate gyrus are different from those of granule cells in the granule cell layer. Brain Res 890 (2001) 261-271
19. Parent J.M., Jessberger S., Gage F.H., and Gong C. Is neurogenesis reparative after status epilepticus?. Epilepsia 48 (2007) 69-71
20. Jakubs K., Nanobashvili A., Bonde S., et al. Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability. Neuron 52 (2006) 1047-1059
21. Kawakita E., Hashimoto M., and Shido O. Docosahexaenoic acid promotes neurogenesis in vitro and in vivo. Neuroscience 139 (2006) 991-997
22. Venna V.R., Deplanque D., Allet C., Belarbi K., Hamdane M., and Bordet R. PUFA induce antidepressant-like effects in parallel to structural and molecular changes in the hippocampus. Psychoneuroendocrinology 34 (2009) 199-211
23. Scharfman H., Goodman J., Macleod A., Phani S., Antonelli C., and Croll S. Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats. Exp Neurol 192 (2005) 348-356
24. Tang F.R., Chia S.C., Jiang F.L., Ma D.L., Chen P.M., and Tang Y.C. Calcium binding protein containing neurons in the gliotic mouse hippocampus with special reference to their afferents from the medial septum and the entorhinal cortex. Neuroscience 140 (2006) 1467-1479
25. Rickman D.W. Parvalbumin immunoreactivity is enhanced by brain-derived neurotrophic factor in organotypic cultures of rat retina. J Neurobiol 41 (1999) 376-384
26. Berghuis P., Agerman K., Dobszay M.B., Minichiello L., Harkany T., and Ernfors P. Brain-derived neurotrophic factor selectively regulates dendritogenesis of parvalbumin-containing interneurons in the main olfactory bulb through the PLCgamma pathway. J Neurobiol 13 (2006) 1437-1451
27. Arango-González B., Cellerino A., and Kohler K. Exogenous brain-derived neurotrophic factor (BDNF) reverts phenotypic changes in the retinas of transgenic mice lacking the BDNF gene. Invest Ophthalmol Vis Sci 50 (2009) 1416-1422
28. Hanover J.L., Huang Z.J., Tonegawa S., and Stryker M.P. Brain-derived neurotrophic factor overexpression induces precocious critical period in mouse visual cortex. J Neurosci 19 (1999) RC40
29. Huang Z.J., Kirkwood A., Pizzorusso T., et al. BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. Cell 98 (1999) 739-755
30. Jones K.F., Farfiias I., Backus C., and Reichardt L.F. Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Cell 76 (1994) 989-999
31. Rocamora N., Pascual M., Acsàdy L., de Lecea L., Freund T.F., and Soriano E. Expression of NGF and NT3 mRNAs in hippocampal interneurons innervated by the GABAergic septohippocampal pathway. J Neurosci 16 (1996) 3991-4004
32. Schmidt-Kastner R., Wetmore C., and Olson L. Comparative study of brain-derived neurotrophic factor messenger RNA and protein at the cellular level suggests multiple roles in hippocampus Striatum and cortex. Neuroscience 74 (1996) 161-183
33. Cellerino A., Maffei L., and Domenici L. The distribution of brain-derived neurotrophic factor and its receptor trkB in parvalbumin-containing neurons of the rat visual cortex. Eur J Neurosci 8 (1996) 1190-1197